DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LBR and lbr

DIOPT Version :9

Sequence 1:	NP_726114.1	Gene:	LBR / 37482	FlyBaseID:	FBgn0034657	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	XP_031757390.1	Gene:	lbr / 100145693	XenbaseID:	XB-GENE-979300	Length:	1069	Species:	Xenopus tropicalis

Alignment Length:	522	Identity:	140/522 - (26%)
Similarity:	236/522 - (45%)	Gaps:	78/522 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   256 DEKSSKRSYSTGEE----DIDEEDELEEDQFRSFNVTRKSATP---------------------A 295
            ||:..:..|....:    .|...:.|||::.|:..|.|.|.:|                     .
Frog   590 DEQRCREKYGPDWDKYCKHIKSVELLEEEEERNEKVLRYSLSPQKESSIPKGIVLTDSGPTESLP 654

  Fly   296 EISCRQLKAPR-EFGGWLGAFLFLLLLPTAVYYLTWSCTARNACQFKHLNLGILLDVNYLTRQVF 359
            |.:.:..:.|: .|||.:|..||::..|..:|.|..:|...:|..:..|.|        |..|||
Frog   655 ETAEKNAENPKLAFGGTVGCLLFMICFPALLYCLLVACGPHSASVYPSLEL--------LDAQVF 711

  Fly   360 QPRVVGAFAAYQVVVFLLVALLPGRRV-------HLTRETYKFNCLAV-SLTLLIASGVAEYLKY 416
                 |.|..: :::...:|:||..:|       :.:|..|:.|.:.| .||...|:.:..|.|.
Frog   712 -----GFFVLW-ILLQASLAILPLGKVVDGVQLGNGSRLKYRMNGIHVFFLTAATAAAMMYYYKI 770

  Fly   417 PVVTFVLRHYLRFCIFGLVGAFVAAAWSYWLVDTAKYNVLRQTLTNDYGRTGSFVVDFALGRQLN 481
            .:: :|..|||:|.....:.:.:.:.:.|    ...|.|..:.|:.. ..:|||:..|.:||::|
Frog   771 NIL-YVYEHYLQFAASATLFSLLFSVYLY----VRSYRVPNEELSWT-ANSGSFIYKFFMGREIN 829

  Fly   482 PKWLGRVDWKQ-FQYRLSLVTTLIYATCYIYQTLVWPQKPQLGEQEGYLYQAKYYWNNVNYDPAT 545
            |: :|.:|.|. |.::|:|::.::     |...:::.:....|..|..|              :.
Frog   830 PR-IGNLDLKTFFMFQLALISWVL-----INAVMLFAEMEVQGRDEPSL--------------SM 874

  Fly   546 LFSASCLLFYVLDAIIFEHHLSSSFELQHEGYGCLLLLRYAA-TPYLLTAVTKYFYEQRVPISCW 609
            :...|..|.||||......:...|.::..:|:|.||....|| .|:..:....|.....|.:. |
Frog   875 ILVNSLQLLYVLDGFWNLEYFLMSPDITRDGFGFLLAFGSAAILPFTYSLQAYYLVNNPVDLP-W 938

  Fly   610 YAPLAVAALLSLGLLVKRFSCAYKYKYRLNSQSPIFANIETIHTYQGSRLLLSGMWGWVRQPNYL 674
            .|..|:.||..||.::.|.:.:.|..:|.|...|.|::::|:.|..||:||:||.||:||:||||
Frog   939 QAACAIVALNLLGFIIYRGANSQKSAFRQNPDDPRFSHLKTLPTSAGSKLLISGWWGFVRRPNYL 1003

  Fly   675 GDIVALLALAAPMALRPAWPPVLGLSLIILLLLHRATRANARNQARYHSSWQRYSTQVRSYILPR 739
            |||:..:|...|.......|....: .:||:||.|..|...|.:.:|...|.:|...||..:||.
Frog  1004 GDIIMGVAWCLPCGFNNMVPYFYAI-FLILILLDRVARDEQRCREKYGPDWDKYCKHVRYRLLPY 1067

  Fly   740 VY 741
            ||
Frog  1068 VY 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LBR	NP_726114.1	PEMT	304..741	CDD:304400	125/447 (28%)
lbr	XP_031757390.1	LBR_tudor	1..55	CDD:401425
		PEMT	249..610	CDD:419701	3/19 (16%)
		PEMT	666..1069	CDD:419701	124/444 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I6894
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000851
OrthoInspector	1	1.000	-	-		oto105328
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X598
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.000