DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HmgD and Hmgb2

DIOPT Version :9

Sequence 1:	NP_001163244.1	Gene:	HmgD / 37481	FlyBaseID:	FBgn0004362	Length:	112	Species:	Drosophila melanogaster
Sequence 2:	NP_058883.1	Gene:	Hmgb2 / 29395	RGDID:	69291	Length:	210	Species:	Rattus norvegicus

Alignment Length:	115	Identity:	44/115 - (38%)
Similarity:	69/115 - (60%)	Gaps:	12/115 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PKRPLSAYMLWLNSARESIKRENPGIKVTEVAKRGGELW--RAMKDKSEWEAKAAKAKDDYDRAV 67
            ||||.||:.|:.:..|..||.|:||:.:.:.||:.||:|  ::.|||..:|.||||.|:.|::.:
  Rat    95 PKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDI 159

  Fly    68 KEFEANGGSSAANGG-----GAKKRAKPAKKVAKKSKKEESDEDDDDESE 112
            ..:.|.|.|.....|     |:||:.:|     :..::||.:|||:||.|
  Rat   160 AAYRAKGKSEVGKKGPGRPTGSKKKNEP-----EDEEEEEEEEDDEDEEE 204

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HmgD	NP_001163244.1	HMGB-UBF_HMG-box	5..68	CDD:238686	28/64 (44%)
Hmgb2	NP_058883.1	HMG_box_2	6..78	CDD:401091
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..102		5/6 (83%)
		HMG_box	95..162	CDD:395407	28/66 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..210		16/48 (33%)
		Required for chemotactic activity. /evidence=ECO:0000250\|UniProtKB:P26583	165..180		3/14 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1641977at2759
OrthoFinder	1	1.000	-	-		FOG0000133
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48112
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920