Protein Alignment KCNC3 and Shab

DIOPT Version :10

• Sequence 1: NP_004968.2
• Gene: KCNC3 / 3748
• HGNCID: 6235
• Length: 757
• Species: Homo sapiens
• Sequence 2: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Alignment Length: 967
• Identity: 251/967 - (25%)
• Similarity: 340/967 - (35%)
• Gaps: 359/967 - (37%)

Human    43 PAQPGPA-----ASPAGPPAPR---GPGDRRAEPCPGLPAAAMGRHGGGGGDSG----------- 88
            ||..|.|     |:|||..:..   |.|...|.|..||||.|:|...|.|..:|
  Fly   142 PAAGGAAYHLGPANPAGLVSRHLDYGDGGHLAGPSAGLPAGAVGSGAGAGAGAGASVTGSGSGAG 206

Human    89 ----------------------------------------------------------------- 88
                                                                             
  Fly   207 TGTGTGAGSGSGSGAAGKEVRYAPFPVASPTHSIPTTSQQIVGSVGGVGVGGASSQSISGGVPTH 271

Human    89 ------------------------------------KIVINVGGVRHETYRSTLRTLPGTRLAGL 117
                                                ::.|||||||||....||..||.|||..|
  Fly   272 SQSNTTGALQRTHSRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRL 336

Human   118 ---TEPEAAARF--DYDPGADEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGID 177
               |..||....  ||....:|:||||||..|:.:||:|||||||...::|...|.::|.:||:|
  Fly   337 RECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVD 401

Human   178 ETDVEACCWMTYRQ-----HRDAEEALDSFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDG 237
            |..:|:||...|.|     |.:..:..:|....|                  ::|.|.|
  Fly   402 ELYLESCCQHKYHQRKENVHEEMRKEAESLRQRD------------------EEEFGEG------ 442

Human   238 AGGELKRLCFQDAGGGAGGPPGGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILI 302
                   .|.:                       :|..:|.|.|.|.:|.|||.:|..|:.||::
  Fly   443 -------KCAE-----------------------YQKYLWELLEKPNTSFAARVIAVISILFIVL 477

Human   303 SITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRI 367
            |.....|.|.....||.|          |.|.:|         |.|..||.||:.|||.|:::|.
  Fly   478 STIALTLNTLPQLQHIDN----------GTPQDN---------PQLAMVEAVCITWFTLEYILRF 523

Human   368 TFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAA---KDVLGFLRVVRFVRILRIFKLTR 429
            :..|||.:|.|..|||||.:||||:::.:.|...:..|.   :||...::|.|.:|||||.||.|
  Fly   524 SASPDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLAR 588

Human   430 HFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGF 494
            |..||:.||.|||.|..|..||::|||:|||||:::.|:||:   |..|      |.|.:||..|
  Fly   589 HSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEK---DEKD------TKFVSIPETF 644

Human   495 WWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKK 559
            |||.:||||:||||:||.|..|.::|.:|.:.|||.||:|:|:|||||..:|...|.::|..|::
  Fly   645 WWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRR 709

Human   560 N--------------KHI---------------------------PRPPQPGSPNYCKPDPPPPP 583
            .              .||                           |:..:..:||..:.......
  Fly   710 EALDRAKREGSIVSFHHINLKDAFAKSMDLIDVIVDTGKQTNVVHPKGKRQSTPNIGRQTLDVQS 774

Human   584 PP--------------------------------------------HPHHGSGG---ISPPPPIT 601
            .|                                            |...||..   ..||....
  Fly   775 APGHNLSQTDGNSTEGESTSGRNPATTGTGCYKNYDHVANLRNSNLHNRRGSSSEQDAVPPYSFD 839

Human   602 PPSMGVTVAGAYPAGPHTHPGLLR-----------------------GGAGGLGIMGLPPLPAPG 643
            .|:...|...|..:.......||:                       |||.|.|:.....:.|..
  Fly   840 NPNARQTSMMAMESYRREQQALLQQQQQQQQQMLQMQQIQQKAPNGNGGATGGGVANNLAMVAAS 904

Human   644 EPCPLAQEEVIEINRADPRPNGDPAAAALAHEDCPAIDQPAMSPEDKSP----ITPGSRGRYSRD 704
            .............|.::..| |...|......|...:|...:|.....|    ||||......|.
  Fly   905 SAATAVATATNASNASNTAP-GSEGAEGGGDGDGGGVDDDNLSQAKGLPIQMMITPGEVAELRRQ 968

Human   705 RA----------------------CFLLT-DYAPSPDGSIRKATGAPPLPPQDWRKP 738
            .|                      ||..| |:....|     |.|...||..|:.||
  Fly   969 VALENLQNQRMDNLEQDVPVEFECCFCTTKDFKEFTD-----AEGVISLPTSDFHKP 1020

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNC3	NP_004968.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..87		20/51 (39%)
		Important for normal N-type inactivation. /evidence=ECO:0000269|PubMed:26997484	1..78		17/42 (40%)
		Potassium_chann	1..>18	CDD:431870
		BTB_KCNC1_3	89..202	CDD:349721	52/122 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..232		2/21 (10%)
		Ion_trans	289..550	CDD:459842	114/263 (43%)
		Selectivity filter. /evidence=ECO:0000250	503..508		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	556..613		14/144 (10%)
		PHA03247	<637..752	CDD:223021	27/129 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	682..746		20/84 (24%)
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	49/107 (46%)
		Ion_trans	464..700	CDD:459842	114/263 (43%)