DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNC3 and KCNQ

DIOPT Version :10

Sequence 1:NP_004968.2 Gene:KCNC3 / 3748 HGNCID:6235 Length:757 Species:Homo sapiens
Sequence 2:NP_788300.3 Gene:KCNQ / 36071 FlyBaseID:FBgn0033494 Length:993 Species:Drosophila melanogaster


Alignment Length:392 Identity:97/392 - (24%)
Similarity:155/392 - (39%) Gaps:112/392 - (28%)


- Green bases have known domain annotations that are detailed below.


Human   269 WRRWQPRVWALFEDPYSSRAARY--VAFASLFFIL-ISITTFCLETHEGFIHISNKTVTQASPIP 330
            :||.|.|::...|.|....|..|  :.|..:|..| :|:.:...|..|..::|            
  Fly    54 YRRLQSRLYNFLERPRGLHAIFYHVMVFLMVFTCLALSVFSTIKEYEEDAVYI------------ 106

Human   331 GAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRI---------TFCPDKVEFLKSSLNIIDC 386
                             |..:|.:.|:|||.||..|:         ..|..:::|:|....|||.
  Fly   107 -----------------LFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDI 154

Human   387 VAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLL 451
            |.||...:.:|: |.|.:..  ....||.:||.:|||:.::.|.....::||..:.|...|.:..
  Fly   155 VTILASIVVLGM-GTSGQVF--ATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITT 216

Human   452 IIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSG 516
            :....||::..:.::|..|:   |.:|       .|.|.....||.|:|:.|:|||||.|.||.|
  Fly   217 MYIGFLGLIFASFLVYMWEK---DVND-------KFSNFAQALWWGVITLCTVGYGDMVPITWQG 271

Human   517 MLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSP--------- 572
            .|:.:.|||.|:...|:|..::    |..::|.:.:|    ::.||:.|..||.:.         
  Fly   272 KLIASCCALLGISFFALPAGIL----GSGFALKVQQQ----QRQKHMIRRRQPAATLIQAVWRCY 328

Human   573 ------------NYCKPDPPPPP------------------PPHPHHGS-----------GGISP 596
                        |..:...|.||                  |....|.|           ||:|.
  Fly   329 AADEHSVSVATWNIHRVALPSPPASRASSSFKHNTSFVARLPTIRRHKSQTIQTPGGGDGGGVSK 393

Human   597 PP 598
            ||
  Fly   394 PP 395

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNC3NP_004968.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..87
Important for normal N-type inactivation. /evidence=ECO:0000269|PubMed:26997484 1..78
Potassium_chann 1..>18 CDD:431870
BTB_KCNC1_3 89..202 CDD:349721
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 210..232
Ion_trans 289..550 CDD:459842 72/272 (26%)
Selectivity filter. /evidence=ECO:0000250 503..508 3/4 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 556..613 17/93 (18%)
PHA03247 <637..752 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 682..746
KCNQNP_788300.3 Ion_trans 72..305 CDD:459842 74/282 (26%)
KCNQ_channel <619..719 CDD:460954
Blue background indicates that the domain is not in the aligned region.

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