DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNC3 and Shaw

DIOPT Version :10

Sequence 1:NP_004968.2 Gene:KCNC3 / 3748 HGNCID:6235 Length:757 Species:Homo sapiens
Sequence 2:NP_001137782.1 Gene:Shaw / 33599 FlyBaseID:FBgn0003386 Length:619 Species:Drosophila melanogaster


Alignment Length:617 Identity:267/617 - (43%)
Similarity:343/617 - (55%) Gaps:116/617 - (18%)


- Green bases have known domain annotations that are detailed below.


Human    89 KIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGADEFFFDRHPGVFAYVLNYYRT 153
            ::|:||||:|||||::||:.:|.|||:.|||    |..:|||..:|:||||||||||.|||||||
  Fly    26 RVVLNVGGIRHETYKATLKKIPATRLSRLTE----ALANYDPILNEYFFDRHPGVFAQVLNYYRT 86

Human   154 GKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDPAGAANAANAAG 218
            ||||.|.|||||||||||.|||:|...||.||||||.||||.:|.|...:..|            
  Fly    87 GKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLD------------ 139

Human   219 AHDGGLDDE-------AGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGGAGGAGGTWWRRWQPRV 276
                 ||.|       |...|...|...|.:                        :||:..:||:
  Fly   140 -----LDTEKPSEEELARKFGFEEDYYKGTI------------------------SWWQEMKPRI 175

Human   277 WALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGF--IHISNKTVTQASPIPGAPPENITN 339
            |:||::||||.||:.:...|:|||.|||.:|||:||...  ..:.|.||..|:   |:....:..
  Fly   176 WSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPDMRVPIVRNITVKTAN---GSNGWFLDK 237

Human   340 VEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSK 404
            .:........|:|.||..|||||.|:|....|:|.||:|||:||||.:|.|.||:::.|...:|.
  Fly   238 TQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFASH 302

Human   405 AAK-DVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYY 468
            ... |:|.|..:   :||:|:||||||..||::|..|.|||..|..||:.||.||::|||:::||
  Fly   303 LENADILEFFSI---IRIMRLFKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYY 364

Human   469 AERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAM 533
            ||||..:|       |..|.:||:|.|||:|||||:|||||.|||:.||.||||||||||||||:
  Fly   365 AERIQPNP-------HNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIAL 422

Human   534 PVPVIVNNFGMYYSLAMAKQKLPKKKNKHIP-----RPPQPGSPNYCKPDPPPPPPPHP-HHGSG 592
            ||||||:||.||||...|:.|||||:.:.:|     :|..||:|........|...||. ..|||
  Fly   423 PVPVIVSNFAMYYSHTQARAKLPKKRRRVLPVEQPRQPRLPGAPGGVSGCGTPGSGPHSGPMGSG 487

Human   593 GISP-------PPPITPPSMGVTVAGAYPAG-------PHT----HPGLLRGGAGGLGIMGLPPL 639
            |..|       ...::|.|:....||  |.|       |.|    :|.|..|          .|.
  Fly   488 GTGPRRMNNKTKDLVSPKSVAQLFAG--PLGASIVAMSPRTMLDLNPALAMG----------KPT 540

Human   640 PAPGEPCPLAQEEVIEINRADPRPNGDPAAAA 671
            ..|..|.|||         |.|.|   |.::|
  Fly   541 FQPRIPTPLA---------ATPPP---PVSSA 560

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNC3NP_004968.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..87
Important for normal N-type inactivation. /evidence=ECO:0000269|PubMed:26997484 1..78
Potassium_chann 1..>18 CDD:431870
BTB_KCNC1_3 89..202 CDD:349721 75/112 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 210..232 4/28 (14%)
Ion_trans 289..550 CDD:459842 131/263 (50%)
Selectivity filter. /evidence=ECO:0000250 503..508 3/4 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 556..613 20/69 (29%)
PHA03247 <637..752 CDD:223021 11/35 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 682..746
ShawNP_001137782.1 BTB_Shaw-like 24..135 CDD:349723 75/112 (67%)
Ion_trans 188..439 CDD:459842 131/263 (50%)
PRK14959 <418..>585 CDD:184923 57/167 (34%)
Blue background indicates that the domain is not in the aligned region.

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