DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNC3 and CG43155

DIOPT Version :10

Sequence 1:NP_004968.2 Gene:KCNC3 / 3748 HGNCID:6235 Length:757 Species:Homo sapiens
Sequence 2:NP_572720.2 Gene:CG43155 / 32092 FlyBaseID:FBgn0262685 Length:411 Species:Drosophila melanogaster


Alignment Length:426 Identity:85/426 - (19%)
Similarity:136/426 - (31%) Gaps:193/426 - (45%)


- Green bases have known domain annotations that are detailed below.


Human   249 DAGGGAGGPPGGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFC----- 308
            ||..|.|...|.|||...|  ..||...|        ..|..::.      :|:|::.:|     
  Fly    33 DAAEGGGLAKGTAGGRRST--ACWQSMKW--------KSALNHIG------LLVSLSIYCGVGGL 81

Human   309 --------------------LETH-EGFIHISNKTVTQASPIPGAPPENITNVEVET-EPFLTY- 350
                                ::|| |.|:|    |:             :.|.||.. :..|:: 
  Fly    82 IFRHLERPAEVERLSHLKDIVKTHRERFLH----TI-------------LNNTEVHNLDELLSFE 129

Human   351 -----------VEGVCVVWFTFEFLMRITFCPDKVE--------FLKSSL-------NIID---- 385
                       .||..::....:|       |:..|        |..|::       ||:.    
  Fly   130 LAKYEAAVQQAAEGGLLIVADKDF-------PEPYERWSILQAVFFSSTVLTTIGYGNIVPVTTG 187

Human   386 ------CVAI--LPFYLEVGLS-GLSSKAAKDVLG-----------FLRVVRFVRILRIFKLTRH 430
                  |.|:  :||.|.|... |.....|..|.|           |:....|..||.:     .
  Fly   188 GRVFCICFALIGIPFTLTVIADWGRLFATAVSVFGKHMPTKPKFTNFIGKTWFYAILAV-----G 247

Human   431 FVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFW 495
            |:|                   ::||.|    |.::...|      ||     .|:|.    ||:
  Fly   248 FLG-------------------VYLAAG----AGLLLLWE------DD-----WTFFD----GFY 274

Human   496 WAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNF------------------ 542
            :..:||||:|:||:.||..:.||:..|..|.|:...:..:.::...:                  
  Fly   275 FCFITMTTIGFGDLVPKKPNYMLLCTLYILIGLALTSTIIELVRRQYATSWAKLQELSGPMAETL 339

Human   543 ---------GMYYS-----LAMAKQKLPKKKNKHIP 564
                     |:.|:     |.::..|...|||:|.|
  Fly   340 RRLGETAGTGLDYTALQKVLTVSMPKWNSKKNEHSP 375

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNC3NP_004968.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..87
Important for normal N-type inactivation. /evidence=ECO:0000269|PubMed:26997484 1..78
Potassium_chann 1..>18 CDD:431870
BTB_KCNC1_3 89..202 CDD:349721
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 210..232
Ion_trans 289..550 CDD:459842 66/370 (18%)
Selectivity filter. /evidence=ECO:0000250 503..508 2/4 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 556..613 5/9 (56%)
PHA03247 <637..752 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 682..746
CG43155NP_572720.2 Ion_trans_2 143..214 CDD:462301 15/77 (19%)
Ion_trans_2 <267..319 CDD:462301 18/55 (33%)
Blue background indicates that the domain is not in the aligned region.

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