Protein Alignment KCNC3 and Ork1

DIOPT Version :10

• Sequence 1: NP_004968.2
• Gene: KCNC3 / 3748
• HGNCID: 6235
• Length: 757
• Species: Homo sapiens
• Sequence 2: NP_001285097.1
• Gene: Ork1 / 32020
• FlyBaseID: FBgn0017561
• Length: 1019
• Species: Drosophila melanogaster
• Alignment Length: 177
• Identity: 39/177 - (22%)
• Similarity: 63/177 - (35%)
• Gaps: 56/177 - (31%)

Human   444 STNEFLLLIIFLALGVLIFATMIYY-------------------------AERIG----ADPDDI 479
            |.|.::||:||. :..|:|...|||                         .|.:|    ...|:|
  Fly     2 SPNRWILLLIFY-ISYLMFGAAIYYHIEHGEEKISRAEQRKAQIAINEYLLEELGDKNTTTQDEI 65

Human   480 LGSNHTY----------FKNIPI------GFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGV 528
            |.....|          :.:.|.      .|::|....:|:|||::.|.|::|.::     :...
  Fly    66 LQRISDYCDKPVTLPPTYDDTPYTWTFYHAFFFAFTVCSTVGYGNISPTTFAGRMI-----MIAY 125

Human   529 LTIAMPVPVIV-----NNFGMYYSLAMAKQKLPKKKNKHIPRPPQPG 570
            ..|.:||..|:     ..||..:.....:.|..|........|||.|
  Fly   126 SVIGIPVNGILFAGLGEYFGRTFEAIYRRYKKYKMSTDMHYVPPQLG 172

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNC3	NP_004968.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..87
		Important for normal N-type inactivation. /evidence=ECO:0000269|PubMed:26997484	1..78
		Potassium_chann	1..>18	CDD:431870
		BTB_KCNC1_3	89..202	CDD:349721
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..232
		Ion_trans	289..550	CDD:459842	33/155 (21%)
		Selectivity filter. /evidence=ECO:0000250	503..508		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	556..613		5/15 (33%)
		PHA03247	<637..752	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	682..746
Ork1	NP_001285097.1	Ion_trans_2	83..144	CDD:462301	14/65 (22%)
		Ion_trans_2	185..266	CDD:462301