DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNC3 and shw-1

DIOPT Version :10

Sequence 1:NP_004968.2 Gene:KCNC3 / 3748 HGNCID:6235 Length:757 Species:Homo sapiens
Sequence 2:NP_001022089.1 Gene:shw-1 / 174331 WormBaseID:WBGene00008819 Length:619 Species:Caenorhabditis elegans


Alignment Length:558 Identity:220/558 - (39%)
Similarity:309/558 - (55%) Gaps:102/558 - (18%)


- Green bases have known domain annotations that are detailed below.


Human    89 KIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGADEFFFDRHPGVFAYVLNYYRT 153
            ::::||||:|||||...|:.:|.|||:.|| |..|   :|||..:|:|||||||||:.:||||||
 Worm   102 RVILNVGGIRHETYSHVLKKIPATRLSRLT-PNLA---NYDPVLNEYFFDRHPGVFSMILNYYRT 162

Human   154 GKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEA----PDPAGAANAA 214
            ||||.|.:||||||||||.|||:|...||.||||||.||||.::.|...|:    .||......|
 Worm   163 GKLHYPTNVCGPLFEEELEFWGLDANQVEPCCWMTYTQHRDTQDTLAVIESLDLDGDPPTQEEIA 227

Human   215 NAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGGAGGAGGTWWRRWQPRVWAL 279
            ...|..|              |...|.:.:                        |:|.:||||||
 Worm   228 KKFGWED--------------DYYTGNMSQ------------------------WQRLKPRVWAL 254

Human   280 FEDPYSSRAARYVAFASLFFILISITTFCLETHEGF----IHISNKTVTQASPIPGAPPENI--T 338
            |::|:||:.||.::..::.|::|||..|||:||..|    |.||......::|:.|....||  .
 Worm   255 FDEPWSSKYARVISVVNIIFVIISIVCFCLKTHPSFRIPDIDISTTMGNFSAPLNGVQMNNIYVG 319

Human   339 NVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSS 403
            .......|...|||.:..:||:.|||.|:.|||:...||::.:|:||.:|.:.||::..|....|
 Worm   320 KTATRAHPSFFYVELLSNIWFSGEFLTRMVFCPNVATFLRTPVNLIDFIATVSFYIDWALDRTLS 384

Human   404 KAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYY 468
            .:.:|.:.|..:   :||||:||||:|..||::|..|.:||..|..||:.|:.||::|||.::||
 Worm   385 GSNRDSVEFFSI---IRILRLFKLTQHSTGLKILIQTFKASAQELFLLVFFVLLGIVIFAALVYY 446

Human   469 AERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAM 533
            |||:..:.::       .|.:||:|.||||:|:.|:|:||:.|:|..|.|||::|||.||||||:
 Worm   447 AERVEHNEEN-------QFSSIPVGLWWAVITICTIGFGDLVPQTSLGRLVGSVCALMGVLTIAL 504

Human   534 PVPVIVNNFGMYYSLAMAKQKLPKKKNK----HIPRP--------------------------PQ 568
            ||||||:||.|:||.|.|:.|||||:.:    |..:|                          |.
 Worm   505 PVPVIVSNFAMFYSHAQARSKLPKKRRRVLQPHEIKPVVGRSTTAVMISALTQRGPVSGGGSNPS 569

Human   569 PGSP----------NYCKPDPPPPPPPHPHHGSGGISP 596
            .|.|          ..|.||....|.....:.:||.:|
 Worm   570 DGGPLSAFSNNTPLLVCPPDGSTKPKKLSQNKNGGTTP 607

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNC3NP_004968.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..87
Important for normal N-type inactivation. /evidence=ECO:0000269|PubMed:26997484 1..78
Potassium_chann 1..>18 CDD:431870
BTB_KCNC1_3 89..202 CDD:349721 69/112 (62%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 210..232 3/21 (14%)
Ion_trans 289..550 CDD:459842 112/266 (42%)
Selectivity filter. /evidence=ECO:0000250 503..508 2/4 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 556..613 15/81 (19%)
PHA03247 <637..752 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 682..746
shw-1NP_001022089.1 BTB_Shaw-like 100..211 CDD:349723 69/112 (62%)
Ion_trans 264..521 CDD:459842 112/266 (42%)
Blue background indicates that the domain is not in the aligned region.

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