Protein Alignment KCNC3 and Kcnc3

DIOPT Version :10

• Sequence 1: NP_004968.2
• Gene: KCNC3 / 3748
• HGNCID: 6235
• Length: 757
• Species: Homo sapiens
• Sequence 2: XP_036008594.1
• Gene: Kcnc3 / 16504
• MGIID: 96669
• Length: 807
• Species: Mus musculus
• Alignment Length: 779
• Identity: 703/779 - (90%)
• Similarity: 711/779 - (91%)
• Gaps: 36/779 - (4%)

Human     1 MLSSVCVSSFRGRQGASKQ--QPAPPPQPPESPPPPPLPPQQQQPAQPGPAASPAGPPAPRGPGD 63
            |||||||.|||||||..||  ||.|.||||||.|||..||||||.:|||.||||||.|...|||.
Mouse     1 MLSSVCVWSFRGRQGTGKQQPQPVPTPQPPESSPPPLPPPQQQQCSQPGTAASPAGAPLSCGPGG 65

Human    64 RRAEPCPGLPAAAMGRHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDY 128
            |||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 RRAEPCPGLPAVAMGRHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDY 130

Human   129 DPGADEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHR 193
            |||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 DPGTDEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHR 195

Human   194 DAEEALDSFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPP 258
            |||||||||||||.:..|| |||.||||.|||||||||||||||||||||||||||||||||||.
Mouse   196 DAEEALDSFEAPDSSANAN-ANAGGAHDAGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPA 259

Human   259 GGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTV 323
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   260 GGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTV 324

Human   324 TQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVA 388
            |||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||
Mouse   325 TQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRVTFCPDKVEFLKSSLNIIDCVA 389

Human   389 ILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLII 453
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   390 ILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLII 454

Human   454 FLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGML 518
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   455 FLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGML 519

Human   519 VGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKPDPPPPP 583
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   520 VGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKPDPPPPP 584

Human   584 PPHPHHGSGGISPPPPITPPSMGVTVAGAYPAGPHTHPGLLRGGAGGLGIMGLPPLPAPGEPCPL 648
            ||||||||||||||||||||||||.||||||.|||||||||||||||||||||||||||||||||
Mouse   585 PPHPHHGSGGISPPPPITPPSMGVNVAGAYPPGPHTHPGLLRGGAGGLGIMGLPPLPAPGEPCPL 649

Human   649 AQEEVIEINRA-----------DPRPNGDPAAAALAHEDCPAIDQPAMSPEDKSPITPGSRGRYS 702
            |||||||.|||           |||||||||||||||||||||||||||||||||||||||||||
Mouse   650 AQEEVIETNRAGSDLGVLEEGVDPRPNGDPAAAALAHEDCPAIDQPAMSPEDKSPITPGSRGRYS 714

Human   703 RDRACFLLTDYAPSPDGSIRKAT----------GAP----PLPPQ---DWRKPG-----PPSFL 744
            |||||||:|||||||||||||||          |.|    |:.|:   :.||..     ||:.|
Mouse   715 RDRACFLVTDYAPSPDGSIRKATPEAPAIFDVSGCPHFTAPITPRKTPERRKTSRRFSVPPTLL 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNC3	NP_004968.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..87		68/87 (78%)
		Important for normal N-type inactivation. /evidence=ECO:0000269|PubMed:26997484	1..78		59/78 (76%)
		Potassium_chann	1..>18	CDD:431870	14/16 (88%)
		BTB_KCNC1_3	89..202	CDD:349721	111/112 (99%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..232		17/21 (81%)
		Ion_trans	289..550	CDD:459842	259/260 (100%)
		Selectivity filter. /evidence=ECO:0000250	503..508		4/4 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	556..613		55/56 (98%)
		PHA03247	<637..752	CDD:223021	96/141 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	682..746		52/85 (61%)
Kcnc3	XP_036008594.1	BTB_KCNC1_3	91..204	CDD:349721	111/112 (99%)
		Ion_trans	290..551	CDD:459842	259/260 (100%)