Protein Alignment CngB and KCNH7

DIOPT Version :10

• Sequence 1: NP_611607.2
• Gene: CngB / 37479
• FlyBaseID: FBgn0266346
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: XP_011510411.1
• Gene: KCNH7 / 90134
• HGNCID: 18863
• Length: 1204
• Species: Homo sapiens
• Alignment Length: 1209
• Identity: 240/1209 - (19%)
• Similarity: 430/1209 - (35%)
• Gaps: 351/1209 - (29%)

  Fly    81 FCDTLERHAFMRNVINQQP--------ESTRRYSTPGEKEAQVRRSL-------EEITKDLKEIE 130
            ||   |...|.|..:.|:|        ..|:|:..     ||:.::|       .|:|...|...
Human    48 FC---EMTGFSRPDVMQKPCTCDFLHGPETKRHDI-----AQIAQALLGSEERKVEVTYYHKNGS 104

  Fly   131 QFVSATEELMQREKEQEQMMY--------SNKENKCPS------PVKRVTYKINAYKAPPRR--- 178
            .|:..|..:..:.:|...||:        .|:....|.      |:|.|..|...:|.|..|
Human   105 TFICNTHIIPVKNQEGVAMMFIINFEYVTDNENAATPERVNPILPIKTVNRKFFGFKFPGLRVLT 169

  Fly   179 HRPGSPRFYHSRLYFRNGKIGCVDSTEHQNNVGATHALVKHILHHEKPLVSP---DSVRRVLEQD 240
            :|..|       |...:..:..:||::|.::..|    :||.....|...||   |..:.:::..
Human   170 YRKQS-------LPQEDPDVVVIDSSKHSDDSVA----MKHFKSPTKESCSPSEADDTKALIQPS 223

  Fly   241 SFEMV-----PLPGAVPE-----IVPDPIAIQRAEELAAATGQVVLPKEEEEEEKSSPLHQVESQ 295
            ....:     ||..:.|:     :.||  .:|.:.:|:.:..:..|.    ...::|.:|.:|.
Human   224 KCSPLVNISGPLDHSSPKRQWDRLYPD--MLQSSSQLSHSRSRESLC----SIRRASSVHDIEG- 281

  Fly   296 PDVDEDEQDVQICYNESPELQNEDR--NERTQRTPSINESEIVAVDEPDTEMNSDVDHRKPSSAG 358
                         :...|:....||  :|...|...::.|.:.         ....:|.|.|..|
Human   282 -------------FGVHPKNIFRDRHASEDNGRNVKVSRSWMA---------GGPFNHIKSSLLG 324

  Fly   359 SL-DSQGQQFLRDQVRHLVRRFTARANKVKSRIELPPTPSSSSTVSSPSPPPTKSLHPSPQHKVR 422
            |. ||...::   ...:.:.:.|...::||:..:....|||..|:.:|.   .|....:...||.
Human   325 STSDSNLNKY---STINKIPQLTLNFSEVKTEKKNSSPPSSDKTIIAPK---VKDRTHNVTEKVT 383

  Fly   423 LV---PAGQSPHRGRLFEADTPRSNVWLCSSLCGANNDERTLDPQGKIYISWLCVVSLSFLYNAW 484
            .|   .|...|.    ::..|||.|.:             |:.........|..::.|..:|.|.
Human   384 QVLSLGADVLPE----YKLQTPRINKF-------------TILHYSPFKAVWDWLILLLVIYTAI 431

  Fly   485 VIPLRASFPFQTKE---NTNIWLAC------DFCADIIYLLDVVFFKHRVMYLFEGFWVKNKNLT 540
            ..|..|:|....:|   ......:|      |...||::::|:: ...|..|:.:...|.:....
Human   432 FTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDIL-INFRTTYVNQNEEVVSDPAK 495

  Fly   541 RKNYMRKLQFKLDLLALLPLELLYFKLGTQAV-----WLRFPRFFKIQSFWEVFRLLDRVISSPH 600
            ...:..|..|.:|::|.:|.:||.|..|:...     .|:..|..::.   .|.|.|||.  |.:
Human   496 IAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLV---RVARKLDRY--SEY 555

  Fly   601 FVRVAKTLTYMLYMI-HITAALYYAYSDYQ------------GLGQNRWVFSGKGH--------- 643
            ...|...|..:..:| |..|.::||..:.:            .|||.    .||.:
Human   556 GAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQ----IGKRYNDSDSSSGP 616

  Fly   644 ----PYVRCFAFATKTATSIG-KNPKPERQGEYVFMTVAWLMGVFVFALLIGQIRDIISTATRNK 703
                .||....|...:.||:| .|..|....|.:|.....|:|..::|.:.|.:..||.......
Human   617 SIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGT 681

  Fly   704 HEYRQLEDETLEYMRRLNLSQEVQSRVKMWFQFTWEQQRTLDESNILDALPINLKTDIAISVHIQ 768
            ..|........|::|...:...::.|::.:||..|.....:|.:.:|...|..|:.||.:.::..
Human   682 ARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQT 746

  Fly   769 TLSKVQLFADCEEALLRDLVLKLRAVTFLPGDFVCRKGEVGREMYIVKLGQVQVMGGPSSDVVLA 833
            .|...:.|....:..||.|.:|.:.....|||.:...|:|...:|.:..|.::::   ..|:|:|
Human   747 LLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEIL---KDDIVVA 808

  Fly   834 TLTEGSVFGE-ISLLGINGADRRTADVRSKGYSNLFVLSKSDLNEVIAYYP-------------- 883
            .|.:..:||| :.|....|  :..||||:..|.:|..:.:.||.||:..||
Human   809 ILGKNDIFGEMVHLYAKPG--KSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFLTNLELTF 871

  Fly   884 -----TAQAIL--------------KKRARQLM------RKNAAREREE---------------E 908
                 :|:|.|              |.|.|:|.      ::|:..:.|:               |
Human   872 NLRHESAKADLLRSQSMNDSEGDNCKLRRRKLSFESEGEKENSTNDPEDSADTIRHYQSSKRHFE 936

  Fly   909 RERARSA------------LQADVV-----IG--------------------------------- 923
            .:::||:            |.:.:|     ||
Human   937 EKKSRSSSFISSIDDEQKPLFSGIVDSSPGIGKASGLDFEETVPTSGRMHIDKRSHSCKDITDMR 1001

  Fly   924 -------NPKTPETAPKLL-----------------------------------------QTVIQ 940
                   :|:..:::|..|                                         ||::|
Human  1002 SWERENAHPQPEDSSPSALQRAAWGISETESDLTYGEVEQRLDLLQEQLNRLESQMTTDIQTILQ 1066

  Fly   941 ALPFES----PAVVLITRGSKRMRRKRQSVQMETIVEPKMEVTGAAETQDQKGLKTGRCSPDLLS 1001
            .|..::    ||..::|.||:   .:|..:|:....:|:     |:...|:....:.:| |:.|.
Human  1067 LLQKQTTVVPPAYSMVTAGSE---YQRPIIQLMRTSQPE-----ASIKTDRSFSPSSQC-PEFLD 1122

  Fly  1002 SIQQELKSKHKF---INLT----DSEKALISQSANNSLE 1033
            ..:.:||||...   ::|.    |:..:|:.|.::.|||
Human  1123 LEKSKLKSKESLSSGVHLNTASEDNLTSLLKQDSDLSLE 1161

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngB	NP_611607.2	PLN03192	411..>891	CDD:215625	122/557 (22%)
		CAP_ED	775..889	CDD:237999	35/133 (26%)
KCNH7	XP_011510411.1	PAS_9	38..134	CDD:463873	20/93 (22%)
		Ion_trans	417..679	CDD:459842	61/271 (23%)
		CAP_ED	753..864	CDD:237999	33/115 (29%)