Protein Alignment CngB and Cnga1

DIOPT Version :10

• Sequence 1: NP_611607.2
• Gene: CngB / 37479
• FlyBaseID: FBgn0266346
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: NP_445949.2
• Gene: Cnga1 / 85259
• RGDID: 621815
• Length: 683
• Species: Rattus norvegicus
• Alignment Length: 747
• Identity: 225/747 - (30%)
• Similarity: 363/747 - (48%)
• Gaps: 135/747 - (18%)

  Fly   274 VVLPKEEEEEEKSSPLHQVES---QPDVDEDEQDVQICYNESPELQNED----RNERTQRTPSIN 331
            ||:|..|:|      :.::|:   ....|.|...:      |.|.:|||    .|...:|.||..
  Rat    18 VVVPAIEKE------IRRMENGACSSFSDNDNGSL------SEESENEDSLFRSNSYRRRGPSQR 70

  Fly   332 ESEI---VAVDEPDTEMNSDVDHRKPSSAGSLDSQGQQFLRDQVRHLVRRFTARANKVKSRIELP 393
            |..:   :|:...:...|.|.|.::                               |.|.:.| .
  Rat    71 EHYLPGTMALFNVNNSSNKDQDPKE-------------------------------KKKKKKE-K 103

  Fly   394 PTPSSSSTVSSPSPPPTKSLHPSPQHKVRLVPAGQSPHRGRLFEADTPRSNVWLCSSLCGANNDE 458
            .:.:.....|...|...|......:.|                :.:.|:..          ..:|
  Rat   104 KSKADDKKESKKDPEKKKKKEKEKEKK----------------KEEKPKEK----------KEEE 142

  Fly   459 R----TLDPQGKIYISWLCVVSLSFLYNAWVIPLRASFPFQTKENTNIWLACDFCADIIYLLDVV 519
            :    .:||.|.:|.:||..::|..:||..:|..||.|.....:....||..|:.:|::||.| :
  Rat   143 KKEVVVIDPSGNMYYNWLFCITLPVMYNWTMIIARACFDELQSDYLEYWLIFDYVSDVVYLAD-M 206

  Fly   520 FFKHRVMYLFEGFWVKNKNLTRKNYMRKLQFKLDLLALLPLELLYFKLGTQAVWLRFPRFFKIQS 584
            |.:.|..||.:|..||:|....:.|...||||||:|:::|.:|||||.|.....:|..|..:|..
  Rat   207 FVRTRTGYLEQGLLVKDKLKLIEKYKANLQFKLDVLSVIPTDLLYFKFGWNYPEIRLNRLLRISR 271

  Fly   585 FWEVFRLLDRVISSPHFVRVAKTLTYMLYMIHITAALYYAYSDYQGLGQNRWVFSGKGHP----- 644
            .:|.|:..:...:.|:..|::..:.|::.:||..|.:||:.|...|.|.:.||:.....|
  Rat   272 MFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVYYSISKAIGFGNDTWVYPDVNDPEFGRL 336

  Fly   645 ---YVRCFAFATKTATSIGKNPKPERQGEYVFMTVAWLMGVFVFALLIGQIRDIISTATRNKHEY 706
               ||....::|.|.|:||:.|.|....||||:.|.:|:||.:||.::|.|..:||.....:.|:
  Rat   337 ARKYVYSLYWSTLTLTTIGETPPPVLDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEF 401

  Fly   707 RQLEDETLEYMRRLNLSQEVQSRVKMWFQFTWEQQRTLDESNILDALPINLKTDIAISVHIQTLS 771
            :...|...:||...|:|::::.||..||.:.|..::|:||..:|..||..|:.:|||:||:.||.
  Rat   402 QSRVDAIKQYMNFRNVSKDMEKRVIKWFDYLWTNKKTVDEREVLRYLPDKLRAEIAINVHLDTLK 466

  Fly   772 KVQLFADCEEALLRDLVLKLRAVTFLPGDFVCRKGEVGREMYIVKLGQVQVMG--GPSSDVVLAT 834
            ||::|||||..||.:|||||:...:.|||::|:||::||||||:|.|::.|:.  |.:..||
  Rat   467 KVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGITQFVV--- 528

  Fly   835 LTEGSVFGEISLLGINGA---DRRTADVRSKGYSNLFVLSKSDLNEVIAYYPTAQAILKKRARQL 896
            |::||.|||||:|.|.|:   :||||:::|.|||:||.|||.||.|.:..||.|:.:|:::.||:
  Rat   529 LSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGRQI 593

  Fly   897 MRKNAAREREEERERARSALQADVVIGN----PK-------TPETAPKLLQTVIQALPFESPAVV 950
            :.|:..               .|:.|.|    ||       ..|.:..||||..        |.:
  Rat   594 LMKDGL---------------LDINIANLGSDPKDLEEKVTRMEGSVDLLQTRF--------ARI 635

  Fly   951 LITRGSKRMRRKRQSVQMETIVEPKMEVTGAA 982
            |....|.:.:.|::..::|..::|.:|...:|
  Rat   636 LAEYESMQQKLKQRLTKVEKFLKPLIETEFSA 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngB	NP_611607.2	PLN03192	411..>891	CDD:215625	177/496 (36%)
		CAP_ED	775..889	CDD:237999	60/118 (51%)
Cnga1	NP_445949.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..144		25/173 (14%)
		Ion_trans	156..398	CDD:459842	82/242 (34%)
		Ion conduction pathway. /evidence=ECO:0000250|UniProtKB:P29973	286..394		37/107 (35%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P29973	353..356		1/2 (50%)
		C-linker. /evidence=ECO:0000250|UniProtKB:P29973	396..472		27/75 (36%)
		CAP_ED	470..586	CDD:237999	60/118 (51%)
		Cyclic nucleotide-binding domain. /evidence=ECO:0000250|UniProtKB:P29973	476..596		58/122 (48%)
		CLZ	586..655	CDD:465160	18/91 (20%)