Protein Alignment CngB and Cnga3

DIOPT Version :10

• Sequence 1: NP_611607.2
• Gene: CngB / 37479
• FlyBaseID: FBgn0266346
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: NP_001385615.1
• Gene: Cnga3 / 85257
• RGDID: 70948
• Length: 670
• Species: Rattus norvegicus
• Alignment Length: 702
• Identity: 223/702 - (31%)
• Similarity: 346/702 - (49%)
• Gaps: 101/702 - (14%)

  Fly   308 CYNESP-ELQNEDRNER--TQRTPSINESEIVAVDEPDTEMNSDVDHRKPSSAGSLDSQGQQFLR 369
            |...|| :|..:|..:|  .|....:..|.     .|..|.:|.|........|.|....|....
  Rat     8 CSQPSPRQLSVKDAADRDLDQVENGLGRSH-----SPCEETSSTVHQGIVMETGELAGAAQSLFT 67

  Fly   370 DQVRHLVRRF--TARANKVKSRIELPPTPSS---------SSTVSSPSPPPTKSLHPSPQHKVRL 423
            .|....|.||  :.||...:......|||.|         ...|||..    ::..|:
  Rat    68 SQGPARVSRFIISIRAWAARHLHHEDPTPDSFLDRFHGAELKEVSSQE----RNAQPN------- 121

  Fly   424 VPAGQSPHRGRLFEADTPRSNVWLCSSLCGANNDERTLDPQGKIYISWLCVVSLSFLYNAWVIPL 488
             |.||.|..|..                 |...|...:||...||..||..::|...||..::..
  Rat   122 -PGGQEPPEGGK-----------------GRKKDPIVVDPSSNIYYRWLTAIALPVFYNWCLLVC 168

  Fly   489 RASFPFQTKENTNIWLACDFCADIIYLLDVVFFKHRVMYLFEGFWVKNKNLTRKNYMRKLQFKLD 553
            ||.|.....|:..:||..|:.||.:|::|:: .:.|..:|.:|..|::.....|:|.:.|.||||
  Rat   169 RACFDELQSEHLTLWLVLDYSADALYVVDML-VRARTGFLEQGLMVRDTKRLWKHYTKTLHFKLD 232

  Fly   554 LLALLPLELLYFKLGTQAVWLRFPRFFKIQSFWEVFRLLDRVISSPHFVRVAKTLTYMLYMIHIT 618
            :|:|:|.:|.|.|||.....|||.|..:....:|.|...:...:.|:..|:...:.|.|.:||..
  Rat   233 ILSLIPTDLAYLKLGMNYPELRFNRLLRFSRLFEFFDRTETRTNYPNVFRIGNLVLYTLIIIHWN 297

  Fly   619 AALYYAYSDYQGLGQNRWVFSGKGHP--------YVRCFAFATKTATSIGKNPKPERQGEYVFMT 675
            |.:|:|.|.:.|.|.:.||:.....|        |:....::|.|.|:||:.|.|.:..||:|:.
  Rat   298 ACIYFAISKFIGFGTDSWVYPNTSKPEYGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVV 362

  Fly   676 VAWLMGVFVFALLIGQIRDIISTATRNKHEYRQLEDETLEYMRRLNLSQEVQSRVKMWFQFTWEQ 740
            :.:|:||.:||.::|.:..:||....::.|::...|...:||:...:::::::||..||.:.|..
  Rat   363 IDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWAN 427

  Fly   741 QRTLDESNILDALPINLKTDIAISVHIQTLSKVQLFADCEEALLRDLVLKLRAVTFLPGDFVCRK 805
            ::|:||..:|..||..||.:|||:||:.||.||::|.|||..||.:||||||...|.|||::|:|
  Rat   428 RKTVDEKEVLKNLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPAVFSPGDYICKK 492

  Fly   806 GEVGREMYIVKLGQVQVMG--GPSSDVVLATLTEGSVFGEISLLGINGA---DRRTADVRSKGYS 865
            |::||||||:|.|::.|:.  |.:..||   |::||.|||||:|.|.|:   :||||::||.|||
  Rat   493 GDIGREMYIIKEGKLAVVADDGVTQFVV---LSDGSYFGEISILNIKGSKSGNRRTANIRSIGYS 554

  Fly   866 NLFVLSKSDLNEVIAYYPTAQAILKKRARQLMRKN------------AAREREEERERARSALQA 918
            :||.|||.||.|.:..||.|:..|:::.||::.|:            .||..||:.|...|:|..
  Rat   555 DLFCLSKDDLMETLTEYPDAKRALEEKGRQILMKDNLIDDDLVTARADARNIEEKVEYLESSLDG 619

  Fly   919 DVVIGNPKTPETAPKLLQTVIQALPFESPAVVLITRGSKRMRRKRQSVQMET 970
                            |||..        |.:|....:.:|:.|::..|:|:
  Rat   620 ----------------LQTRF--------ARLLAEYSASQMKLKQRLSQLES 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngB	NP_611607.2	PLN03192	411..>891	CDD:215625	176/492 (36%)
		CAP_ED	775..889	CDD:237999	62/118 (53%)
Cnga3	NP_001385615.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25		5/16 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	111..138		10/55 (18%)
		Ion_trans	148..390	CDD:459842	76/242 (31%)
		Ion conduction pathway. /evidence=ECO:0000250|UniProtKB:P29973	278..386		34/107 (32%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P29973	345..348		1/2 (50%)
		C-linker. /evidence=ECO:0000250|UniProtKB:P29973	388..464		26/75 (35%)
		CAP_ED	462..578	CDD:237999	62/118 (53%)
		Cyclic nucleotide-binding domain. /evidence=ECO:0000250|UniProtKB:P29973	468..588		61/122 (50%)
		CLZ	578..647	CDD:465160	19/92 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	644..670		2/4 (50%)