Protein Alignment CngB and KCNH6

DIOPT Version :10

• Sequence 1: NP_611607.2
• Gene: CngB / 37479
• FlyBaseID: FBgn0266346
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: NP_110406.1
• Gene: KCNH6 / 81033
• HGNCID: 18862
• Length: 994
• Species: Homo sapiens
• Alignment Length: 743
• Identity: 165/743 - (22%)
• Similarity: 277/743 - (37%)
• Gaps: 166/743 - (22%)

  Fly   345 MNSDVDHRKPSSAGSLDSQGQQFLRDQVRHLVRRFTARANKVKSRIELPPTPSSSSTVSSPSPPP 409
            :.|:..|.:|...|....:|:.....|:......| ...|..|.|        ||||.......|
Human   154 LGSEGSHGRPGGPGPGTGRGKYRTISQIPQFTLNF-VEFNLEKHR--------SSSTTEIEIIAP 209

  Fly   410 TKSLHPS------------------PQHKVRLVPAGQSP--HRGRLFEADTPRSNVWLCSSLCGA 454
            .|.:..:                  |::|:      |:|  ||..:... :|...||
Human   210 HKVVERTQNVTEKVTQVLSLGADVLPEYKL------QAPRIHRWTILHY-SPFKAVW-------- 259

  Fly   455 NNDERTLDPQGKIYISWLCVVSLSFLYNAWVIPLRASFPFQTKENTNIWLAC----------DFC 509
                           .||  :.|..:|.|...|..|:|....::.:... ||          |..
Human   260 ---------------DWL--ILLLVIYTAVFTPYSAAFLLSDQDESRRG-ACSYTCSPLTVVDLI 306

  Fly   510 ADIIYLLDVVFFKHRVMYLFEGFWVKNKNLTRKNYMRKLQ-------FKLDLLALLPLELLYFKL 567
            .||::::|:| ...|..|:       |.|....::.|::.       |.:|::|.:|.:||.|:.
Human   307 VDIMFVVDIV-INFRTTYV-------NTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRT 363

  Fly   568 GTQAV-----WLRFPRFFKIQSFWEVFRLLDRVISSPHFVRVAKTLTYMLYMIHITAALYYA--- 624
            |:...     .|:..|..::.   .|.|.|||.......|......|:.| :.|..|.::||
Human   364 GSDETTTLIGLLKTARLLRLV---RVARKLDRYSEYGAAVLFLLMCTFAL-IAHWLACIWYAIGN 424

  Fly   625 ----YSDYQGLGQNRWVFS-----GKGH-------------PYVRCFAFATKTATSIG-KNPKPE 666
                |.::: :|   |:.|     ||.:             .||....|...:.||:| .|..|.
Human   425 VERPYLEHK-IG---WLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPN 485

  Fly   667 RQGEYVFMTVAWLMGVFVFALLIGQIRDIISTATRNKHEYRQLEDETLEYMRRLNLSQEVQSRVK 731
            ...|.||.....|:|..::|.:.|.:..||.........|........|::|...:...::.|::
Human   486 TNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLE 550

  Fly   732 MWFQFTWEQQRTLDESNILDALPINLKTDIAISVHIQTLSKVQLFADCEEALLRDLVLKLRAVTF 796
            .:||..|.....:|.:.:|...|..|:.||.:.:|...|.....|:...:..||.|.:|.:....
Human   551 EYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHA 615

  Fly   797 LPGDFVCRKGEVGREMYIVKLGQVQVMGGPSSDVVLATLTEGSVFGE-ISLLGINGADRRTADVR 860
            .|||.:...|:|...:|.:..|.::::   ..|||:|.|.:..:||| :||....|  :.:||||
Human   616 PPGDTLVHLGDVLSTLYFISRGSIEIL---RDDVVVAILGKNDIFGEPVSLHAQPG--KSSADVR 675

  Fly   861 SKGYSNLFVLSKSDLNEVIAYYPT-AQAILKKRARQLMRKNAAREREEERERA------RSALQA 918
            :..|.:|..:.::||.||:..||. |::...|.......::||........:|      :....:
Human   676 ALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFNLRDAAGGLHSSPRQAPGSQDHQGFFLS 740

  Fly   919 DVVIGNPKTPETAPKLLQTVIQALPFESPAVVLITRGSKRMRRKRQSVQMETIVEPKMEVTGAAE 983
            |...|:|.  |..|:          |.|....|:..||:................|.:.::
Human   741 DNQSGSPH--ELGPQ----------FPSKGYSLLGPGSQNSMGAGPCAPGHPDAAPPLSIS---- 789

  Fly   984 TQDQKGLKTGRCSPDLLSSIQQELKSKH 1011
              |..||     .|:||    ||:..:|
Human   790 --DASGL-----WPELL----QEMPPRH 806

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngB	NP_611607.2	PLN03192	411..>891	CDD:215625	126/549 (23%)
		CAP_ED	775..889	CDD:237999	36/115 (31%)
KCNH6	NP_110406.1	PAS_9	38..132	CDD:463873
		PLN03192	259..>698	CDD:215625	114/485 (24%)