Protein Alignment CngB and HCN2

DIOPT Version :10

• Sequence 1: NP_611607.2
• Gene: CngB / 37479
• FlyBaseID: FBgn0266346
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: NP_001185.3
• Gene: HCN2 / 610
• HGNCID: 4846
• Length: 889
• Species: Homo sapiens
• Alignment Length: 687
• Identity: 151/687 - (21%)
• Similarity: 277/687 - (40%)
• Gaps: 128/687 - (18%)

  Fly   393 PPTPSSSSTVS--------------SPSPPPTKSLHPSPQHKVRLVPAGQSPHRGRLFEADT--- 440
            |.||.::||..              ||:.|...:..|......|...:|.:|..|...||.:
Human    85 PGTPGAASTAKGSPNGECGRGEPQCSPAGPEGPARGPKVSFSCRGAASGPAPGPGPAEEAGSEEA 149

  Fly   441 -----PR-SNVWLCSSLCGA---------------------NNDERT-------LDPQGKIYISW 471
                 || |.........||                     ...||.       :.|.......|
Human   150 GPAGEPRGSQASFMQRQFGALLQPGVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYW 214

  Fly   472 LCVVSLSFLYNAWVIPLRASFPFQTKENTNIWLACDFCADIIYLLDVVF-FKHRVMYLFEGFWVK 535
            ...:.|..:.|..:||:..:| |: .|.|..|:..:..:|..:|:|:|. |:..::.......:.
Human   215 DFTMLLFMVGNLIIIPVGITF-FK-DETTAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIIL 277

  Fly   536 NKNLTRKNYMRKLQFKLDLLALLPLELLYF--------KLGTQAVWLRFPRFFKIQSFWEVFRLL 592
            :....:|.|:| ..|.:|.::.:|::.::.        ::...|..||..||.||.|...:.| |
Human   278 DPEKIKKKYLR-TWFVVDFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLR-L 340

  Fly   593 DRVISSPH---------------FVRVAKTLTYMLYMIHITAALYYAYSDYQGLGQNRWV-FSGK 641
            .|:|...|               .:|:...::.||.:.|....|.:.....|...:|.|| .:|.
Human   341 SRLIRYIHQWEEIFHMTYDLASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWVSINGM 405

  Fly   642 -GHPYVRCFAFATKTATS----IGKNPK-PERQGEYVFMTVAWLMGVFVFALLIGQIRDIISTAT 700
             .|.:...::||...|.|    ||...: ||...:.....::.::|...:|:.||....:|.:..
Human   406 VNHSWSELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLD 470

  Fly   701 RNKHEYRQLEDETLEYMRRLNLSQEVQSRVKMWFQFTWEQQRTLDESNILDALPINLKTDIAISV 765
            .::.:|::...:..:||....|..:.:.::..:::..: |.:..||.:||..|...|:.:|....
Human   471 SSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRY-QGKMFDEDSILGELNGPLREEIVNFN 534

  Fly   766 HIQTLSKVQLFADCEEALLRDLVLKLRAVTFLPGDFVCRKGEVGREMYIVKLGQVQVMGGPSSDV 830
            ..:.::.:.|||:.:...:..::.||:...|.|||::.|:|.:|::||.::.|.|.|:...:.::
Human   535 CRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEM 599

  Fly   831 VLATLTEGSVFGEISLLGINGADRRTADVRSKGYSNLFVLSKSDLNEVIAYYP----TAQAILKK 891
               .|::||.||||.||   ...||||.||:..|..|:.||..:.|||:..||    ..:.:...
Human   600 ---KLSDGSYFGEICLL---TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAID 658

  Fly   892 RARQLMRKNAAREREEERE-------RARSALQADVV-----------IGN-------PKTPETA 931
            |..::.:||:....:.:.:       ...:|:..::|           :|.       |..|...
Human   659 RLDRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQQAELGQRVGLFPPPPPPPQV 723

  Fly   932 PKLLQTVIQALPFE------SPAVVLITRGSKRMRRK 962
            ...:.|:.||....      .|.|..:..||.|:.|:
Human   724 TSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRR 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngB	NP_611607.2	PLN03192	411..>891	CDD:215625	126/551 (23%)
		CAP_ED	775..889	CDD:237999	41/117 (35%)
HCN2	NP_001185.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..159		17/73 (23%)
		PBP1	<57..185	CDD:444064	20/99 (20%)
		PLN03192	150..>688	CDD:215625	122/548 (22%)
		Involved in subunit assembly. /evidence=ECO:0000250	158..209		6/50 (12%)
		CAP_ED	544..652	CDD:237999	41/113 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	754..889		3/7 (43%)