Protein Alignment CngB and Hcn4

DIOPT Version :10

• Sequence 1: NP_611607.2
• Gene: CngB / 37479
• FlyBaseID: FBgn0266346
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: NP_067690.1
• Gene: Hcn4 / 59266
• RGDID: 71065
• Length: 1198
• Species: Rattus norvegicus
• Alignment Length: 819
• Identity: 186/819 - (22%)
• Similarity: 314/819 - (38%)
• Gaps: 187/819 - (22%)

  Fly   275 VLPKEEEEEEKSSPLHQVESQPDVDEDEQDVQICYNESPELQNEDRNERTQRTPSI----NESEI 335
            ::.:||:.||:.:...|       |...:.:::....||             :||:    :||..
  Rat    25 IMDEEEDGEEEGAGGLQ-------DPSRRSIRLRPLPSP-------------SPSVAAGCSESRG 69

  Fly   336 VAVDEPDTE----------MNSDVDHRKPSSAGSLDSQG-----------QQFLRDQVRHLVRRF 379
            .|:...|:|          .|.|. .|...|..||.|:|           ...|.|..... |..
  Rat    70 AALGAADSEGPGRSAGKSSTNGDC-RRFRGSLASLGSRGGGSGGAGGGSSLGHLHDSAEER-RLI 132

  Fly   380 TARANKVKSRIELPP----TPSSSSTVSSP--SPPPTKSLHPS---------------------- 416
            .|..:........||    .|......:.|  ||||.:...|:
  Rat   133 AAEGDASPGEDRTPPGLATEPERPGAAAQPAASPPPQQPPQPASASCEQPSADTAIKVEGGAAAS 197

  Fly   417 ----PQHKVRLVPAGQSPHRGRLFEAD-TPRSNVW----LCSSLCGANNDERT-------LDPQG 465
                |:.:|||   |||....|.|.|. .|..|.:    ..|........||.       :.|..
  Rat   198 DQILPEAEVRL---GQSGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYS 259

  Fly   466 KIYISWLCVVSLSFLYNAWVIPLRASFPFQTKENTNIWLACDFCADIIYLLDVVF-FKHRVMYLF 529
            .....|...:.|..:.|..:||:..:| |: .|||..|:..:..:|..:|:|:|. |:..::...
  Rat   260 DFRFYWDLTMLLLMVGNLIIIPVGITF-FK-DENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVED 322

  Fly   530 EGFWVKNKNLTRKNYMRKLQFKLDLLALLPLELLYFKLGTQ--------AVWLRFPRFFKIQSFW 586
            ....:.:....:..|: |..|.:|.::.:|::.::..:.|:        |..||..||.||.|..
  Rat   323 NTEIILDPQRIKMKYL-KSWFVVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLL 386

  Fly   587 EVFRLLDRVISSPH---------------FVRVAKTLTYMLYMIHITAALYY-----------AY 625
            .:.| |.|:|...|               .||:...:..||.:.|....|.:           .:
  Rat   387 RLLR-LSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPHDCW 450

  Fly   626 SDYQGLGQNRWVFSGKGHPYVRCFAFATKTATSIGKNPKPERQGEYVFMTVAWL------MGVFV 684
            ....|:..|.|   ||.:.|....|.:.......|:...       |.|:..||      :|...
  Rat   451 VSINGMVNNSW---GKQYSYALFKAMSHMLCIGYGRQAP-------VGMSDVWLTMLSMIVGATC 505

  Fly   685 FALLIGQIRDIISTATRNKHEYRQLEDETLEYMRRLNLSQEVQSRVKMWFQFTWEQQRTLDESNI 749
            :|:.||....:|.:...::.:|::...:..:||....|..:.:.|:..:::..: |.:..||.:|
  Rat   506 YAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRY-QGKMFDEESI 569

  Fly   750 LDALPINLKTDIAISVHIQTL-SKVQLFADCEEALLRDLVLKLRAVTFLPGDFVCRKGEVGREMY 813
            |..|...|:.:| |:.:.:.| :.:.|||:.:...:..::.|||...|.|||::.|:|.:|::||
  Rat   570 LGELSEPLREEI-INFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMY 633

  Fly   814 IVKLGQVQVMGGPSSDVVLATLTEGSVFGEISLLGINGADRRTADVRSKGYSNLFVLSKSDLNEV 878
            .::.|.|.|:...:.:..||   :||.||||.||   ...||||.||:..|..|:.||..:.|||
  Rat   634 FIQHGVVSVLTKGNKETKLA---DGSYFGEICLL---TRGRRTASVRADTYCRLYSLSVDNFNEV 692

  Fly   879 IAYYP----TAQAILKKRARQLMRKNAA----------------RERE-------EERERARSA- 915
            :..||    ..:.:...|..::.:||:.                :|.|       .:||.|..|
  Rat   693 LEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQIVRHDREMAHCAH 757

  Fly   916 -LQADVVIGNPKTPETAPKLLQTVIQALPFESPAVVLIT 953
             :||........||.....|:|..:||....:...:.:|
  Rat   758 RVQAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALT 796

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngB	NP_611607.2	PLN03192	411..>891	CDD:215625	133/563 (24%)
		CAP_ED	775..889	CDD:237999	43/117 (37%)
Hcn4	NP_067690.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..183		36/179 (20%)
		Involved in subunit assembly. /evidence=ECO:0000250	209..260		12/50 (24%)
		Ion_trans_N	218..260	CDD:400630	8/41 (20%)
		PLN03192	253..>740	CDD:215625	121/508 (24%)
		CAP_ED	595..703	CDD:237999	43/113 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	804..1198