DRSC/TRiP Functional Genomics Resources

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Protein Alignment CngB and HCN3

DIOPT Version :10

Sequence 1:NP_611607.2 Gene:CngB / 37479 FlyBaseID:FBgn0266346 Length:1040 Species:Drosophila melanogaster
Sequence 2:NP_065948.1 Gene:HCN3 / 57657 HGNCID:19183 Length:774 Species:Homo sapiens


Alignment Length:630 Identity:150/630 - (23%)
Similarity:258/630 - (40%) Gaps:114/630 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   393 PPTPSSSSTVSSPSPPPTKS-----LHPSPQHKVRLVPAGQSPHRGRLFEADTPRS-NVWLCSSL 451
            ||..::|..:....|.|.:.     |.|: .:|..|...|.  |:....|.:..:| ..|:    
Human    28 PPATAASGPIPKSGPEPKRRHLGTLLQPT-VNKFSLRVFGS--HKAVEIEQERVKSAGAWI---- 85

  Fly   452 CGANNDERTLDPQGKIYISWLCVVSLSFLYNAWVIPLRASFPFQTKENTNIWLACDFCADIIYLL 516
                     :.|.......|..::.|..:.|..|:|:..:| |: :||:..|:..:..:|..:||
Human    86 ---------IHPYSDFRFYWDLIMLLLMVGNLIVLPVGITF-FK-EENSPPWIVFNVLSDTFFLL 139

  Fly   517 DVVFFKHRVMYLFEGFWV-KNKNLTRKNYMRKLQFKLDLLALLPLELLYFKLGTQ---------- 570
            |:|......:.:.||..: ......|..|:| ..|.:||::.:|::.::..:..:          
Human   140 DLVLNFRTGIVVEEGAEILLAPRAIRTRYLR-TWFLVDLISSIPVDYIFLVVELEPRLDAEVYKT 203

  Fly   571 AVWLRFPRFFKIQSFWEVFRLLDRVISSPH---------------FVRVAKTLTYMLYMIHITAA 620
            |..||..||.||.|...:.| |.|:|...|               .||:...:..||.:.|....
Human   204 ARALRIVRFTKILSLLRLLR-LSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGC 267

  Fly   621 LYYAYSDYQGLGQNRWVFSGK--GHPYVRCFAFATKTATS----IGKNPKPERQGEYVFMTVAWL 679
            |.:.....|....:.||....  .|.:.|.::.|...|.|    ||..     |...|.|...||
Human   268 LQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSHALFKAMSHMLCIGYG-----QQAPVGMPDVWL 327

  Fly   680 ------MGVFVFALLIGQIRDIISTATRNKHEYRQLEDETLEYMRRLNLSQEVQSRVKMWFQFTW 738
                  :|...:|:.||....:|.:...::.:|::...:..:||....|..:.:.|:..:::..:
Human   328 TMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRY 392

  Fly   739 EQQRTLDESNILDALPINLKTDIAISVHIQTLSKVQLFADCEEALLRDLVLKLRAVTFLPGDFVC 803
             |.:..||.:||..|...|:.:|........::.:.|||..:.:.:..::.|||...|.|||.|.
Human   393 -QGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVV 456

  Fly   804 RKGEVGREMYIVKLGQVQVMGGPSSDVVLATLTEGSVFGEISLLGINGADRRTADVRSKGYSNLF 868
            |:|.|||:||.::.|.:.|:...:.|   ..||:||.||||.||   ...||||.||:..|..|:
Human   457 REGSVGRKMYFIQHGLLSVLARGARD---TRLTDGSYFGEICLL---TRGRRTASVRADTYCRLY 515

  Fly   869 VLSKSDLNEVIAYYP----TAQAILKKRARQLMRKNAARER-------------------EEERE 910
            .||....|.|:..:|    ..:.:...|..::.:||:..:|                   :.:|:
Human   516 SLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKKNSILQRKRSEPSPGSSGGIMEQHLVQHDRD 580

  Fly   911 RARSALQADVVIGNPKTPETA------PKLLQTVIQALPFESPAV 949
            .||..        ..:.|.|.      |.|.:.::.| |.::.||
Human   581 MARGV--------RGRAPSTGAQLSGKPVLWEPLVHA-PLQAAAV 616

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CngBNP_611607.2 PLN03192 411..>891 CDD:215625 130/527 (25%)
CAP_ED 775..889 CDD:237999 44/117 (38%)
HCN3NP_065948.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..48 5/19 (26%)
Involved in subunit assembly. /evidence=ECO:0000250 46..91 10/60 (17%)
Ion_trans_N 49..91 CDD:400630 10/57 (18%)
Ion_trans 93..358 CDD:459842 63/273 (23%)
Interaction with KCTD3. /evidence=ECO:0000250|UniProtKB:O88705 354..774 72/279 (26%)
CAP_ED 428..536 CDD:237999 44/113 (39%)
PHA03247 <586..753 CDD:223021 8/32 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 682..774
Blue background indicates that the domain is not in the aligned region.

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