Protein Alignment CngB and kcnh2a

DIOPT Version :10

• Sequence 1: NP_611607.2
• Gene: CngB / 37479
• FlyBaseID: FBgn0266346
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: XP_073775577.1
• Gene: kcnh2a / 563802
• ZFINID: ZDB-GENE-070912-699
• Length: 1254
• Species: Danio rerio
• Alignment Length: 731
• Identity: 160/731 - (21%)
• Similarity: 280/731 - (38%)
• Gaps: 124/731 - (16%)

  Fly   226 PLV-SPDSVRRVLEQDSFE--MVPLPGAVPEIVPDPIAIQRAEELAAATGQVVLPKEEEEEEKSS 287
            ||: |....::.|.:|:.:  |.|:|....|.|.....:...|..|....|::..:::.:.|..|
Zfish   169 PLLHSLSGSKQSLHEDTEKGFMQPMPHMGHESVALDKLLSLPERSALGGSQLLFWEDKAQTESES 233

  Fly   288 PLHQVESQPDVDEDEQDVQICYNESPELQNEDRNERTQRTPSINES---EIVAVDEPDTEMNSDV 349
            .|...|..|.:.:...      ..||.|.|. .:|.:..:.|:..|   |.:....|....|...
Zfish   234 ELRPSEVSPPLPQGFS------QSSPRLHNL-TSEASPSSCSMAHSRSCESLCGMRPSPSTNDFN 291

  Fly   350 DHRK----PSSAGSLDSQGQQFLRDQVRHLVR-RFTARANKVK-SRIELPP-----TPSSSSTVS 403
            ..||    |||.|::..:...........|:| |.:.|..::. :.|::.|     .|:....:.
Zfish   292 WDRKLPVRPSSTGAMHRKASLQNATSDSDLIRLRSSGRGTQISHNLIDMKPDALIAVPTGEIDII 356

  Fly   404 SPSPPPTKSLHPSPQHKVRLVPAGQS--PHRGRLFEADTPRSNVWLCSSLCGANNDERTLDPQGK 466
            :|.....:: |...:...:::..|..  |.    ::...||.:.|             |:.....
Zfish   357 APCKLIDRT-HNVTEKVTQVLSLGADVLPE----YKLQAPRIHKW-------------TILHYSP 403

  Fly   467 IYISWLCVVSLSFLYNAWVIPLRASFPFQTKENTNI---WLAC------DFCADIIYLLDVVFFK 522
            ....|..|:.|..:|.|...|..|:|....:|...|   ..:|      |...||::::|:| ..
Zfish   404 FKAVWDWVILLLVIYTAIFTPYSAAFLLSDEEEEVIQRCGYSCSTLNVVDLIVDIMFVVDIV-IN 467

  Fly   523 HRVMYL-----------------FEGFWVKNKNLTRKNYMRKLQFKLDLLALLPLELLYFK---- 566
            .|..|:                 |:| |                |.:|::|.:|.:||.::
Zfish   468 FRTTYVNSNDEVVSQPGRIAVHYFKG-W----------------FLIDMVAAIPFDLLIYRSEEE 515

  Fly   567 LGTQAVWLRFPRFFKIQSFWEVFRLLDRVISSPHFVRVAKTLTYMLYMIHITAALYYAYSDYQGL 631
            ..|....:...:..::.....|.|.|||.......|......|:.| :.|..|.::||..:.:..
Zfish   516 TTTSTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFAL-IAHWLACIWYAIGNVERS 579

  Fly   632 GQNR--WVFS--------------GKG----HPYVRCFAFATKTATSIG-KNPKPERQGEYVFMT 675
            |.:|  |:.|              |.|    ..||....|...:.||:| .|..|....|.:|..
Zfish   580 GPSRIGWLNSLGDQLGKPYNSSVRGSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSI 644

  Fly   676 VAWLMGVFVFALLIGQIRDIISTATRNKHEYRQLEDETLEYMRRLNLSQEVQSRVKMWFQFTWEQ 740
            ...|:|..::|.:.|.:..||.........|........|::|...:...::.|::.:||..|..
Zfish   645 CVMLIGALMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSY 709

  Fly   741 QRTLDESNILDALPINLKTDIAISVHIQTLSKVQLFADCEEALLRDLVLKLRAVTFLPGDFVCRK 805
            ...:|.:.:|...|..|:.||.:.::...|...:.|....:..||.|.:|.:.....|||.:...
Zfish   710 TNGIDMNAVLKGFPECLQADICLHLNRTLLQSCKAFKGSSKGCLRALAMKFKTTHAPPGDTLVHA 774

  Fly   806 GEVGREMYIVKLGQVQVMGGPSSDVVLATLTEGSVFGEISLLGINGADR---RTADVRSKGYSNL 867
            |:|...:|.:..|.::::.|   |||:|.|.:..:|||    .||...|   .:||||:..|.:|
Zfish   775 GDVISALYFISRGSIEILKG---DVVVAILGKNDIFGE----PINSYARPGKSSADVRALTYCDL 832

  Fly   868 FVLSKSDLNEVIAYYP 883
            ..:.:.|:.||:..||
Zfish   833 HKIHRDDVLEVLEMYP 848

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngB	NP_611607.2	PLN03192	411..>891	CDD:215625	118/529 (22%)
		CAP_ED	775..889	CDD:237999	35/112 (31%)
kcnh2a	XP_073775577.1	None