Protein Alignment CngB and hcn2b

DIOPT Version :10

• Sequence 1: NP_611607.2
• Gene: CngB / 37479
• FlyBaseID: FBgn0266346
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: XP_685414.3
• Gene: hcn2b / 557285
• ZFINID: ZDB-GENE-030131-8228
• Length: 979
• Species: Danio rerio
• Alignment Length: 780
• Identity: 176/780 - (22%)
• Similarity: 302/780 - (38%)
• Gaps: 160/780 - (20%)

  Fly   393 PPTPSSSSTVSSPSPPPTKSLHPSPQHKVRLVPAGQS------------PHRGRLFEADTPRSNV 445
            ||.....|.||..|..|...  |||.:     |||.|            ...|...:..|.....
Zfish   132 PPADKKDSRVSFSSAAPAHG--PSPSN-----PAGNSVSFSKSEDGQITAEDGEARDNQTYMQRQ 189

  Fly   446 WLCSSLCGAN---------------NDERT-------LDPQGKIYISWLCVVSLSFLYNAWVIPL 488
            :......|.|               ..||.       :.|.......|...:.:..:.|..:||:
Zfish   190 FSAMLQPGVNKFSLRMFGSQKAVEKEQERVKSAGNWIIHPYSDFRFYWDFTMLMFMVGNLIIIPV 254

  Fly   489 RASFPFQTKENTNIWLACDFCADIIYLLDVVF-FKHRVMYLFEGFWVKNKNLTRKNYMRKLQFKL 552
            ..:| |: :|.|..|:..:..:|..:|:|:|. |:..::|......:.:....:|.|: |..|.:
Zfish   255 GITF-FK-EETTTPWIIFNVVSDTFFLMDLVLNFRTGIVYEDNTEIILDPEKIKKKYL-KTWFVV 316

  Fly   553 DLLALLPLELLYF--------KLGTQAVWLRFPRFFKIQSFWEVFRLLDRVISSPH--------- 600
            |.::.:|::.::.        ::...|..||..||.||.|...:.| |.|:|...|
Zfish   317 DFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLR-LSRLIRYIHQWEEIFHMT 380

  Fly   601 ------FVRVAKTLTYMLYMIHITAALYYAYSDYQGLGQNRWVFSGK--GHPYVRCFAFATKTAT 657
                  .:|:...:..||.:.|....|.:.....|....:.||...|  ...:...::||...|.
Zfish   381 YDLASAVMRIINLIGMMLLLCHWDGCLQFLVPMLQDFPSDCWVSLNKMVNDSWSELYSFALFKAM 445

  Fly   658 S----IGKNPK-PERQGEYVFMTVAWLMGVFVFALLIGQIRDIISTATRNKHEYRQLEDETLEYM 717
            |    ||...: ||...:.....::.::|...:|:.||....:|.:...::.:|::...:..:||
Zfish   446 SHMLCIGYGRQAPESMSDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYM 510

  Fly   718 RRLNLSQEVQSRVKMWFQFTWEQQRTLDESNILDALPINLKTDIAISVHIQTLSKVQLFADCEEA 782
            ....|..:.:.::..:::..: |.:..||.:||:.|...|:.:|......:.::.:.|||:.:..
Zfish   511 SFHKLPADFRQKIHDYYEHRY-QGKMFDEESILEELNEPLREEIVNFNCRKLVASMPLFANADPN 574

  Fly   783 LLRDLVLKLRAVTFLPGDFVCRKGEVGREMYIVKLGQVQVMGGPSSDVVLATLTEGSVFGEISLL 847
            .:..::.|||...|.|||::.|:|.:|::||.::.|.|.|:   :...:...|::||.||||.||
Zfish   575 FVTAMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVL---TKGNIGMKLSDGSYFGEICLL 636

  Fly   848 GINGADRRTADVRSKGYSNLFVLSKSDLNEVIAYYPTAQ------------------AILKKRAR 894
               ...||||.||:..|..|:.||..:.|||:..||..:                  :||..:.:
Zfish   637 ---TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILMHKVQ 698

  Fly   895 QLMRKNAAREREEE---------RERARSALQADV---------------VIGNPKTPETAPKLL 935
            ..:.......||.|         ||..:...|.|:               :.|....|.|: ..:
Zfish   699 HDLNSGVFNNRENEMIQEIVKYDREMVKLVKQGDMQRPRAMSMTPSTHGSMFGPSSQPSTS-SAI 762

  Fly   936 QTVIQALPFE------SPAVVLITRGSKRMRRKRQSVQMETIVEPKME------VTGAAETQDQK 988
            .|:.||:...      :|.:...:..|.||.|:.|.||.:|  .|..:      .:..|.|....
Zfish   763 ATLQQAVAMSFCPQMGNPLMGSGSVQSPRMVRRFQVVQTQT--PPGSQYSTLARASALASTPVHS 825

  Fly   989 GLKT------------GRCSPDLLSSIQQELKSK------HKFINLTDSEKALISQSANNSLEDM 1035
            .|.|            |..|...||.:||.:.|.      |: ..||...:|| |.|..:...||
Zfish   826 PLATTARTFQYGSSPPGAPSGSQLSLVQQLVPSPTHRPAVHR-STLTQDARAL-SASQPSLRPDM 888

  Fly  1036  1035
            Zfish   889  888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngB	NP_611607.2	PLN03192	411..>891	CDD:215625	126/562 (22%)
		CAP_ED	775..889	CDD:237999	42/131 (32%)
hcn2b	XP_685414.3	PLN03192	164..>711	CDD:215625	120/557 (22%)
		CAP_ED	567..675	CDD:237999	42/113 (37%)
		PHA03247	<736..977	CDD:223021	36/158 (23%)