Protein Alignment CngB and CNGB3

DIOPT Version :10

• Sequence 1: NP_611607.2
• Gene: CngB / 37479
• FlyBaseID: FBgn0266346
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: NP_061971.3
• Gene: CNGB3 / 54714
• HGNCID: 2153
• Length: 809
• Species: Homo sapiens
• Alignment Length: 750
• Identity: 247/750 - (32%)
• Similarity: 403/750 - (53%)
• Gaps: 78/750 - (10%)

  Fly   279 EEEEEEKSSPLHQVESQPDVDEDEQDVQICYNESPELQNEDRNERTQRTPSINESEIVAVDEPDT 343
            |..|.|:||..::..|.|.....:...|      .|.:.|:::.:|:.||..:|.....:.:..:
Human    16 ENNENEQSSRRNEEGSHPSNQSQQTTAQ------EENKGEEKSLKTKSTPVTSEEPHTNIQDKLS 74

  Fly   344 EMNSDVD---HRKPSSA----GSLDSQGQ----------------------QFLRDQVRHLVRRF 379
            :.||..|   :..|.:|    |::..|.:                      ::...|:.:||:|.
Human    75 KKNSSGDLTTNPDPQNAAEPTGTVPEQKEMDPGKEGPNSPQNKPPAAPVINEYADAQLHNLVKRM 139

  Fly   380 TARANKVKSRI---ELPPTPSSSSTVSSPSPPPTKSLHPSP-QH-------KVRLVPAGQSPHRG 433
            ..|....|.::   :|....:|..|....:.||.|.....| :|       ||:.:|..:...|.
Human   140 RQRTALYKKKLVEGDLSSPEASPQTAKPTAVPPVKESDDKPTEHYYRLLWFKVKKMPLTEYLKRI 204

  Fly   434 RLFEADTPRSNVWLCSSLCGANNDERTLDPQGKIYISWLCVVSLSFLYNAWVIPLRASFPFQTKE 498
            :|                  .|:.:...|   ::|:.||.:|:|::.:|...||||..||:||.:
Human   205 KL------------------PNSIDSYTD---RLYLLWLLLVTLAYNWNCCFIPLRLVFPYQTAD 248

  Fly   499 NTNIWLACDFCADIIYLLDVVFFKHRVMYLFEGFWVKNKNLTRKNYMRKLQFKLDLLALLPLELL 563
            |.:.||..|...|||||.|::|.:.|:.::..|..:.:.|..||:|....:|:||:.:::|.::.
Human   249 NIHYWLIADIICDIIYLYDMLFIQPRLQFVRGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDIC 313

  Fly   564 YFKLGTQAVWLRFPRFFKIQSFWEVFRLLDRVISSPHFVRVAKTLTYMLYMIHITAALYYAYSDY 628
            |...|...:: |..|..|..||:|....|:.::...:..||.:|..|:|:::||.|.:||..|:|
Human   314 YLFFGFNPMF-RANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNY 377

  Fly   629 QGLGQNRWVFSGKGHPYVRCFAFATKTATSIGKNPKPERQGEYVFMTVAWLMGVFVFALLIGQIR 693
            :|:|..|||:.|:|:.|:||:.:|.:|..:||..|:|:...|.||..:.:..|||||:.||||:|
Human   378 EGIGTTRWVYDGEGNEYLRCYYWAVRTLITIGGLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMR 442

  Fly   694 DIISTATRNKHEYRQLEDETLEYMRRLNLSQEVQSRVKMWFQFTWEQQRTLDESNILDALPINLK 758
            |:|..||.|::.:|...|:|:.||...::.:.||.||:.|:::||:.||.||||::|..||..::
Human   443 DVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQ 507

  Fly   759 TDIAISVHIQTLSKVQLFADCEEALLRDLVLKLRAVTFLPGDFVCRKGEVGREMYIVKLGQVQVM 823
            ..:||.|:...:|||.||..|:..::.|::|:|::|.:|||||||:|||:|:||||:|.|:|||:
Human   508 LALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVL 572

  Fly   824 GGPSSDVVLATLTEGSVFGEISLLGINGADRRTADVRSKGYSNLFVLSKSDLNEVIAYYPTAQAI 888
            |||....||.||..||||||||||...|.:||||:|.:.|::||..|.|..|.|::.:||.::.|
Human   573 GGPDGTKVLVTLKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILVHYPDSERI 637

  Fly   889 LKKRARQLMRKNAAREREEERERARSALQADVVIGNPKTPETAPKLLQTVIQALPFESPAVVLIT 953
            |.|:||.|: |..|:..|....|...||     :..||  |..|||.:|::......|.|.:|..
Human   638 LMKKARVLL-KQKAKTAEATPPRKDLAL-----LFPPK--EETPKLFKTLLGGTGKASLARLLKL 694

  Fly   954 RGSKRMRRKRQSVQMETIVEPKMEVTGAAETQDQK 988
            :..:..::|..|...|.  |.|.......|.:|::
Human   695 KREQAAQKKENSEGGEE--EGKENEDKQKENEDKQ 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngB	NP_611607.2	PLN03192	411..>891	CDD:215625	188/487 (39%)
		CAP_ED	775..889	CDD:237999	59/113 (52%)
CNGB3	NP_061971.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..121		21/110 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	153..178		6/24 (25%)
		Ion_trans	231..453	CDD:459842	85/222 (38%)
		Ion conduction pathway. /evidence=ECO:0000305|PubMed:34969976	348..447		43/98 (44%)
		Selectivity filter. /evidence=ECO:0000305|PubMed:34969976	407..410		1/2 (50%)
		C-linker. /evidence=ECO:0000305|PubMed:34969976	450..526		29/75 (39%)
		CAP_ED	524..639	CDD:237999	60/114 (53%)
		Cyclic nucleotide-binding domain. /evidence=ECO:0000305|PubMed:34969976, ECO:0000305|PubMed:37463923, ECO:0007744|PDB:8EUC	530..646		61/115 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	698..776		7/31 (23%)