Protein Alignment CngB and KCNH2

DIOPT Version :10

• Sequence 1: NP_611607.2
• Gene: CngB / 37479
• FlyBaseID: FBgn0266346
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: XP_047276304.1
• Gene: KCNH2 / 3757
• HGNCID: 6251
• Length: 1185
• Species: Homo sapiens
• Alignment Length: 1030
• Identity: 203/1030 - (19%)
• Similarity: 355/1030 - (34%)
• Gaps: 279/1030 - (27%)

  Fly    81 FCDTLERHAFMRNVINQQPESTRRYSTPGEKEAQVRRSLEEITKDLKEIEQFVSATEELMQREKE 145
            ||   |...:.|..:.|:|.:......|..:    ||:..:|             .:.|:..|:.
Human    74 FC---ELCGYSRAEVMQRPCTCDFLHGPRTQ----RRAAAQI-------------AQALLGAEER 118

  Fly   146 QEQMMYSNKENKC------PSPVKR-----VTYKIN-----------------AYKAPPRRH-RP 181
            :.::.:..|:..|      ..|||.     :.:.:|                 .::.||... .|
Human   119 KVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAP 183

  Fly   182 GSPRFYHSRL-----------YFRNGKIGCVDSTEHQNNVGATHALVKHILHHEKPLVSPDSVRR 235
            |..:.:..:|           ..|:|..|         ..||..|:|..:   :....:|.|...
Human   184 GRAKTFRLKLPALLALTARESSVRSGGAG---------GAGAPGAVVVDV---DLTPAAPSSESL 236

  Fly   236 VLEQ--------------DSFEMVPLPGAVPEIVPDPIAIQRAEEL-AAATGQVVLPKEEEEEEK 285
            .|::              :....:..||:.|...|..:...||..| ..|:|...........|.
Human   237 ALDEVTAMDNHVAGLGPAEERRALVGPGSPPRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRES 301

  Fly   286 SSPLHQVESQPDVDEDEQDVQICYNESPELQNEDRNERTQRTPSINESEIVAVDEPDTEMNSDVD 350
            .:.:.:..|..|::.....|         |....|:..|.....:....:.:..:.|......:.
Human   302 CASVRRASSADDIEAMRAGV---------LPPPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTIS 357

  Fly   351 HRKPSSAGSLDSQGQQFLRDQV--RHLVRRFTARANKVKSRIELPPTPSSSSTVSSPSPPPTKSL 413
            .....:...:|.:|..||....  |.::      |.|:|.|     |.:.:..|:.     ..||
Human   358 KIPQITLNFVDLKGDPFLASPTSDREII------APKIKER-----THNVTEKVTQ-----VLSL 406

  Fly   414 HPS--PQHKVRLVPAGQSP--HRGRLFEADTPRSNVWLCSSLCGANNDERTLDPQGKIYISWLCV 474
            ...  |::|:      |:|  ||..:... :|...||                       .||
Human   407 GADVLPEYKL------QAPRIHRWTILHY-SPFKAVW-----------------------DWL-- 439

  Fly   475 VSLSFLYNAWVIPLRASFPFQTKEN----TNIWLAC------DFCADIIYLLDVVFFKHRVMYL- 528
            :.|..:|.|...|..|:|..:..|.    |....||      |...||::::|:: ...|..|:
Human   440 ILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDIL-INFRTTYVN 503

  Fly   529 ----------------FEGFWVKNKNLTRKNYMRKLQFKLDLLALLPLELLYFKLGTQAV--WLR 575
                            |:| |                |.:|::|.:|.:||.|..|::.:  .|:
Human   504 ANEEVVSHPGRIAVHYFKG-W----------------FLIDMVAAIPFDLLIFGSGSEELIGLLK 551

  Fly   576 FPRFFKIQSFWEVFRLLDRVISSPHFVRVAKTLTYMLYMIHITAALYYAYSDYQ----------- 629
            ..|..::.   .|.|.|||.......|......|:.| :.|..|.::||..:.:
Human   552 TARLLRLV---RVARKLDRYSEYGAAVLFLLMCTFAL-IAHWLACIWYAIGNMEQPHMDSRIGWL 612

  Fly   630 -GLGQ---NRWVFSGKGHP-----YVRCFAFATKTATSIG-KNPKPERQGEYVFMTVAWLMGVFV 684
             .||.   ..:..||.|.|     ||....|...:.||:| .|..|....|.:|.....|:|..:
Human   613 HNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLM 677

  Fly   685 FALLIGQIRDIISTATRNKHEYRQLEDETLEYMRRLNLSQEVQSRVKMWFQFTWEQQRTLDESNI 749
            :|.:.|.:..||.........|........|::|...:...::.|::.:||..|.....:|.:.:
Human   678 YASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAV 742

  Fly   750 LDALPINLKTDIAISVHIQTLSKVQLFADCEEALLRDLVLKLRAVTFLPGDFVCRKGEVGREMYI 814
            |...|..|:.||.:.::...|...:.|....:..||.|.:|.:.....|||.:...|::...:|.
Human   743 LKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYF 807

  Fly   815 VKLGQVQVMGGPSSDVVLATLTEGSVFGE-ISLLGINGADRRTADVRSKGYSNLFVLSKSDLNEV 878
            :..|.::::.|   |||:|.|.:..:||| ::|....|  :...|||:..|.:|..:.:.||.||
Human   808 ISRGSIEILRG---DVVVAILGKNDIFGEPLNLYARPG--KSNGDVRALTYCDLHKIHRDDLLEV 867

  Fly   879 IAYYP--------TAQAILKKR------------------ARQLMRKNAARER---EEERERARS 914
            :..||        :.:.....|                  :||..||.:.|.|   :.|:....|
Human   868 LDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVS 932

  Fly   915 AL------------------QADVVIGNPKTPETA----PKLLQTVIQALPFESP 947
            ||                  ..:.....|.:||::    |....:.::.:||.||
Human   933 ALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSP 987

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngB	NP_611607.2	PLN03192	411..>891	CDD:215625	123/542 (23%)
		CAP_ED	775..889	CDD:237999	33/122 (27%)
KCNH2	XP_047276304.1	PAS_9	64..156	CDD:463873	18/101 (18%)
		Ion_trans	435..694	CDD:459842	67/305 (22%)
		CAP_ED	768..879	CDD:237999	33/115 (29%)