Protein Alignment CngB and KCNH1

DIOPT Version :10

• Sequence 1: NP_611607.2
• Gene: CngB / 37479
• FlyBaseID: FBgn0266346
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: NP_758872.1
• Gene: KCNH1 / 3756
• HGNCID: 6250
• Length: 989
• Species: Homo sapiens
• Alignment Length: 716
• Identity: 157/716 - (21%)
• Similarity: 276/716 - (38%)
• Gaps: 169/716 - (23%)

  Fly   410 TKSLHPSPQHKVRLVPA---GQSPHR-GRLFEADTPRSNVWLCSSLCGANNDERTLDPQGKIY-- 468
            |::|..|.....:|.|:   |::.|: .||.|.      :.|.|.:......|....|...|.
Human   155 TRALTSSRGVLQQLAPSVQKGENVHKHSRLAEV------LQLGSDILPQYKQEAPKTPPHIILHY 213

  Fly   469 ----ISWLCVVSLSFLYNAWVIPLRASFPFQTKENTNIWLACDFCADIIYLLDVVFFKHRVMYLF 529
                .:|..::.:...|.|.::|...|  |:|::|...||..|...|:|:|:|:|...|......
Human   214 CVFKTTWDWIILILTFYTAILVPYNVS--FKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGP 276

  Fly   530 EGFWVKNKNLTRKNYMRKLQFKLDLLALLPLELLYF---------------KLG----------- 568
            .|..:.:..|.|.||: |..|.:|||:.||.:::..               |:|
Human   277 AGEVISDPKLIRMNYL-KTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEG 340

  Fly   569 --TQAVWLRFP--RFFKIQSFWEVFRLLDRVISSPHFVRVAKTLTYMLYMI-----HITAALYYA 624
              :|.:...|.  :..::.....|.|.||      |::.....:..:|..:     |..|.::|:
Human   341 RESQGISSLFSSLKVVRLLRLGRVARKLD------HYIEYGAAVLVLLVCVFGLAAHWMACIWYS 399

  Fly   625 YSDYQ-------GLGQNRWVF----------------SGK--GHP-----YVRCFAFATKTATSI 659
            ..||:       .:..|.|::                |||  |.|     |:....|...:.||:
Human   400 IGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSV 464

  Fly   660 G-KNPKPERQGEYVFMTVAWLMGVFVFALLIGQIRDIISTATRNKHEYRQLEDETLEYMRRLNLS 723
            | .|..|....|.:|.....::|..::|.:.|.:..|......|.:.|.::.:...::::...:.
Human   465 GFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVP 529

  Fly   724 QEVQSRVKMWFQFTWEQQRTLDESNILDALPINLKTDIAISVHIQTLSKVQLFADCEEALLRDLV 788
            :.:..||..:...||...|.:|...:|...|.:::.||.:.::.:...:...|....:..||.|.
Human   530 KGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALA 594

  Fly   789 LKLRAVTFLPGDFVCRKGEVGREMYIVKLGQVQVMGGPSSDVVLATLTEGSVFGEISLLGINGAD 853
            ::.:.|...|||.:...||....:..|..|.::|:   ..|.|:|.|.:|.|||::.......|
Human   595 MEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVI---QDDEVVAILGKGDVFGDVFWKEATLA- 655

  Fly   854 RRTADVRSKGYSNLFVLSKSDLNEVIAYYPTAQAILKK--------RARQLMRKNAAREREEERE 910
            :..|:||:..|.:|.|:.:..|.:|:.:|........:        |.|.:.||.:..:|||| |
Human   656 QSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEE-E 719

  Fly   911 RARSALQADVVIGNPKTPETAPKLLQTVIQALPFESPAVVLITRGSKRMRRKRQSVQMETIVEPK 975
            |.:...:|.::                    ||.:.|    :.|..:|.|:::
Human   720 RMKRKNEAPLI--------------------LPPDHP----VRRLFQRFRQQK------------ 748

  Fly   976 MEVTGAAETQDQKGLKTGRCSPDLLSSIQQELKSKHKFINLTDSEKALI---SQSANNSLEDMKV 1037
             |...|||       :.||...||                  |.||..:   ..|||:||....|
Human   749 -EARLAAE-------RGGRDLDDL------------------DVEKGNVLTEHASANHSLVKASV 787

  Fly  1038 V 1038
            |
Human   788 V 788

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngB	NP_611607.2	PLN03192	411..>891	CDD:215625	121/555 (22%)
		CAP_ED	775..889	CDD:237999	31/113 (27%)
KCNH1	NP_758872.1	PAS_9	41..135	CDD:463873
		Required for phosphatidylinositol bisphosphate binding. /evidence=ECO:0000269|PubMed:27005320	151..162		2/6 (33%)
		PLN03192	220..>647	CDD:215625	97/438 (22%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:Q63472	463..468		2/4 (50%)
		PRK11753	608..>712	CDD:236969	27/107 (25%)
		Calmodulin-binding. /evidence=ECO:0000269|PubMed:10880439	673..770		31/159 (19%)
		Interaction with cyclic nucleotide-binding pocket. /evidence=ECO:0000250|UniProtKB:Q60603	699..701		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	855..886
		CAD (involved in subunit assembly). /evidence=ECO:0000250|UniProtKB:Q63472	924..964
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	962..989