DRSC/TRiP Functional Genomics Resources

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Protein Alignment CngB and Cngb1

DIOPT Version :10

Sequence 1:NP_611607.2 Gene:CngB / 37479 FlyBaseID:FBgn0266346 Length:1040 Species:Drosophila melanogaster
Sequence 2:NP_001182342.1 Gene:Cngb1 / 333329 MGIID:2664102 Length:1325 Species:Mus musculus


Alignment Length:950 Identity:296/950 - (31%)
Similarity:461/950 - (48%) Gaps:171/950 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   110 EKEAQVRRSLEEITKDLKEIEQFVSATEELMQREKEQEQMMYSNKENKCPSPVKRVTYKINAYKA 174
            |||.:.::..||..|:.:|.|:.....||..:.|||:|:.....:|.:                 
Mouse   391 EKEEEKKKGEEEKEKEEEEKEKEKEKEEEKEEEEKEEEEEEEKEEEEE----------------- 438

  Fly   175 PPRRHRPGSPRFYHSRLYFRNGKIGCVDSTEHQNNVGATHALVKHILHHEKPLVSPDSVRRVLEQ 239
                                       :..|.:..........:.....|:|:|..||. .|::.
Mouse   439 ---------------------------EKEEEEKEEEEKEEEEEEEEEEEEPIVLLDSC-LVVQA 475

  Fly   240 DSFEMVPLPGAVPEIVPDPIAIQRAEELAAATGQVVLPKEEEEEEKSSPLHQVESQPDVDEDEQD 304
            |               .|...::|.....|:..::...|||:||||.....:.|.:.:.:.::::
Mouse   476 D---------------VDECQLERTPSELASIQELPEEKEEKEEEKEEEKEEEEEKKEEEVEKKE 525

  Fly   305 VQICYN-------ESPELQNEDRN---------------ERTQRTP------------------- 328
            .....|       |.||||.||.:               ||...:|                   
Mouse   526 EGEATNSTVPATKEHPELQVEDTDADSGPLIPEETLPPPERPPPSPVKSDTLTVPGAAAAGHRKK 590

  Fly   329 --------------SINESEIVAVDEPDTEMNSDVDHRKPSSAGSLDSQGQQFLRDQVRHLVRRF 379
                          |..||.:||..:|.|...:|...|..|:|    ||....:.|:::.||:.|
Mouse   591 LPSQDDEAEELKALSPAESPVVAWSDPTTPQEADGQDRAASTA----SQNSAIINDRLQELVKMF 651

  Fly   380 TARANKVKSRIELPPTPSSSSTVSSPSPPPTKSLHPSPQHKVRLVPAGQSPHRGRLFEADTPRSN 444
            ..|..|||.::   ..|..:|...||.|.|.|.. |.|.      || |.|....:.|.:     
Mouse   652 KERTEKVKEKL---IDPDVTSDEESPKPSPAKKA-PEPD------PA-QKPAEAEVAEEE----- 700

  Fly   445 VWLCSSLC--------GANNDERTLDP-QGKIYISWLCVVSLSFLYNAWVIPLRASFPFQTKENT 500
             ..|..||        ......:::|| ...:||.||..|.|::.:|.|:||:|.:||:|..:|.
Mouse   701 -HYCDMLCCKFKRRPLKMYRFPQSIDPLTNLMYILWLFFVVLAWNWNCWLIPVRWAFPYQRADNI 764

  Fly   501 NIWLACDFCADIIYLLDVVFFKHRVMYLFEGFWVKNKNLTRKNYMRKLQFKLDLLALLPLELLYF 565
            :.||..|:..|.|||||:..|:.|:.::..|..:.:|...|.||::..:||:|||.||||:.||.
Mouse   765 HFWLLMDYLCDFIYLLDITVFQMRLQFVKGGDIITDKKEMRNNYLKSRRFKMDLLCLLPLDFLYL 829

  Fly   566 KLGTQAVWLRFPRFFKIQSFWEVFRLLDRVISSPHFVRVAKTLTYMLYMIHITAALYYAYSDYQG 630
            |||...: ||.||..|..:|:|....|:.::|..:..||.:|..|:||.:|:.:.|||..|.:||
Mouse   830 KLGINPL-LRLPRCLKYMAFFEFNNRLEAILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAFQG 893

  Fly   631 LGQNRWVFSGKGHPYVRCFAFATKTATSIGKNPKPERQGEYVFMTVAWLMGVFVFALLIGQIRDI 695
            :|...||:.|.|:.|:||:.:|.||..:||..|.|:...|.||..:.:..|||.|:::|||:||:
Mouse   894 IGSTHWVYDGVGNSYIRCYYWAVKTLITIGGLPDPQTLFEIVFQLLNYFTGVFAFSVMIGQMRDV 958

  Fly   696 ISTATRNKHEYRQLEDETLEYMRRLNLSQEVQSRVKMWFQFTWEQQRTLDESNILDALPINLKTD 760
            :..||..:..||...|.|::||....:.:.||:|||.|:::||..|..||||.::..||..::.|
Mouse   959 VGAATAGQTYYRSCMDSTVKYMNFYKIPRSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLD 1023

  Fly   761 IAISVHIQTLSKVQLFADCEEALLRDLVLKLRAVTFLPGDFVCRKGEVGREMYIVKLGQVQVMGG 825
            :||.|:...:|||.||..|:..::.|::.:||:|.:||.|:||:|||:||||||::.|||||:||
Mouse  1024 LAIDVNYSIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGG 1088

  Fly   826 PSSDVVLATLTEGSVFGEISLLGINGADRRTADVRSKGYSNLFVLSKSDLNEVIAYYPTAQAILK 890
            |....||.||..||||||||||.:.|.:||||:|.:.|::|||:|.|.||||::.:||.:|.:|:
Mouse  1089 PDGKAVLVTLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLR 1153

  Fly   891 KRARQLMRKNAAREREEERERARSALQADVVIGNPKTPETAPKLLQTVIQALPFESPAVVLITRG 955
            |:||:::|.|  .:.:||:         .|:|..|:.  ..|||....:.|.....|      ||
Mouse  1154 KKARRMLRNN--NKPKEEK---------SVLILPPRA--GTPKLFNAALAAAGKMGP------RG 1199

  Fly   956 SK-----RMR-RKRQSVQMETIVEPKMEVTGAAETQDQKG 989
            :|     .:| |.::...:|.....:..:..|..:|:..|
Mouse  1200 AKGGKLAHLRARLKELAALEAAARQQQLLEQAKSSQEAGG 1239

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CngBNP_611607.2 PLN03192 411..>891 CDD:215625 200/488 (41%)
CAP_ED 775..889 CDD:237999 62/113 (55%)
Cngb1NP_001182342.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..124
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 147..198
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 227..279
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 340..470 20/122 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 482..637 34/158 (22%)
Calmodulin-binding CaM1. /evidence=ECO:0000250|UniProtKB:Q28181 633..643 3/13 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 659..694 14/45 (31%)
PLN03192 724..>1110 CDD:215625 167/386 (43%)
Ion conduction pathway. /evidence=ECO:0000250|UniProtKB:Q14028 862..961 40/98 (41%)
C-linker. /evidence=ECO:0000250|UniProtKB:Q14028 964..1040 29/75 (39%)
CAP_ED 1038..1147 CDD:237999 60/108 (56%)
cNMP-binding domain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00060 1038..1142 59/103 (57%)
Cyclic nucleotide-binding domain. /evidence=ECO:0000250|UniProtKB:Q14028 1044..1160 63/115 (55%)
Calmodulin-binding CaM2. /evidence=ECO:0000250|UniProtKB:Q28181 1224..1230 0/5 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1226..1325 2/13 (15%)
Blue background indicates that the domain is not in the aligned region.

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