Protein Alignment CngB and Cngb3

DIOPT Version :10

• Sequence 1: NP_611607.2
• Gene: CngB / 37479
• FlyBaseID: FBgn0266346
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: NP_038955.1
• Gene: Cngb3 / 30952
• MGIID: 1353562
• Length: 694
• Species: Mus musculus
• Alignment Length: 702
• Identity: 230/702 - (32%)
• Similarity: 377/702 - (53%)
• Gaps: 78/702 - (11%)

  Fly   275 VLPKEEEEEEKSSPLHQVESQPDVDEDEQDVQ---------ICYNESPELQNEDRNERTQR--TP 328
            |.|.|...|:|..|.....|||.:.:.:...:         |.:.:|...::....|.:.|  ||
Mouse    12 VNPMEGRMEKKLCPNLSSLSQPTIAQGDNQSEKEPLRSRTPITFEKSHSKEDNSTGENSLRDFTP 76

  Fly   329 SINESEIVAVDEPDTEMNSDVDH------------RKPSSAGSL---DSQGQQFLRDQVRHLVRR 378
            :           ||.|..:::..            .:|.|..:.   .|...::....:.:||.|
Mouse    77 N-----------PDPECRAELTRTMAEMEKTRTGKERPVSFKTKVLETSIINEYTDAHLHNLVER 130

  Fly   379 FTARANKVKSRI----ELPPTPSSSSTVSSPSPPPTKSLHPS-PQH------KVRLVPAGQSPHR 432
            ...|....|..:    ..|...:||.|..|.:..|.:..:.. .:|      |.:.||..:  |.
Mouse   131 MRERTALYKKTLTEEENFPEVEASSQTAMSTNISPKQENNSKLKEHQDTFSFKPQRVPVKE--HL 193

  Fly   433 GRLFEADTPRSNVWLCSSLCGANNDERTLDPQGKIYISWLCVVSLSFLYNAWVIPLRASFPFQTK 497
            .|:.   .|||            .|..|    .::|:.||.:|::::.:|.|::|:|..||.||.
Mouse   194 RRMI---LPRS------------IDSYT----DRVYLLWLLLVTIAYNWNCWLLPVRLVFPCQTP 239

  Fly   498 ENTNIWLACDFCADIIYLLDVVFFKHRVMYLFEGFWVKNKNLTRKNYMRKLQFKLDLLALLPLEL 562
            :|.|.|:..|...|||||.|::..:.|:.::..|..:.:.|..::||....:|::|:.:|||.|:
Mouse   240 DNKNYWIITDIVCDIIYLCDILLIQPRLQFVRGGEIIVDSNELKRNYRSSTKFRMDVASLLPFEV 304

  Fly   563 LYFKLGTQAVWLRFPRFFKIQSFWEVFRLLDRVISSPHFVRVAKTLTYMLYMIHITAALYYAYSD 627
            ||...|...:: |..|..|..||:|....|:.::...:..||.:|..|:|:::||.|.:||..||
Mouse   305 LYIFFGVNPIF-RANRILKYTSFFEFNHHLESIMDKAYVYRVIRTTGYLLFLLHINACVYYWASD 368

  Fly   628 YQGLGQNRWVFSGKGHPYVRCFAFATKTATSIGKNPKPERQGEYVFMTVAWLMGVFVFALLIGQI 692
            |:|:|..:||::|:|:.|:|||.:|.:|..:||..|:|:...|.||..:.:..|||||:.||||:
Mouse   369 YEGIGSTKWVYNGEGNKYLRCFYWAVRTLITIGGLPEPQTSFEIVFQFLNFFSGVFVFSSLIGQM 433

  Fly   693 RDIISTATRNKHEYRQLEDETLEYMRRLNLSQEVQSRVKMWFQFTWEQQRTLDESNILDALPINL 757
            ||:|..||.|::.::...|..:.||.:.::.|.||.||:.|.::||..||.|||||:|:.||..:
Mouse   434 RDVIGAATANQNYFQACMDHIIAYMNKYSIPQSVQYRVRTWLEYTWNSQRILDESNLLENLPTAM 498

  Fly   758 KTDIAISVHIQTLSKVQLFADCEEALLRDLVLKLRAVTFLPGDFVCRKGEVGREMYIVKLGQVQV 822
            :..||:.::...:.||:||..|:..::.||:|:|::..:|||||||:|||:|:||||:|.|:|||
Mouse   499 QLSIALDINFSIIDKVELFKGCDTQMIYDLLLRLKSTIYLPGDFVCKKGEIGKEMYIIKHGEVQV 563

  Fly   823 MGGPSSDVVLATLTEGSVFGEISLLGINGADRRTADVRSKGYSNLFVLSKSDLNEVIAYYPTAQA 887
            :|||....||.||..||||||||||...|.:||||||.:.|::||..|.|..|.|::.:|||::.
Mouse   564 LGGPDGAQVLVTLKAGSVFGEISLLAKGGGNRRTADVVAHGFANLLTLDKKTLQEILLHYPTSKK 628

  Fly   888 ILKKRARQLMRKNAAREREEERERARSALQADVVIGNPKTPETAPKLLQTVI 939
            :|.|:|:.|:      .::.:..:|..|......:..||  |..|::|:.::
Mouse   629 LLMKKAKILL------SQKGKTTQAIPARPGPAFLFPPK--EETPRMLKVLL 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngB	NP_611607.2	PLN03192	411..>891	CDD:215625	188/486 (39%)
		CAP_ED	775..889	CDD:237999	61/113 (54%)
Cngb3	NP_038955.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..82		12/68 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	146..177		6/30 (20%)
		PLN03192	202..>588	CDD:215625	159/390 (41%)
		Ion conduction pathway. /evidence=ECO:0000250|UniProtKB:Q9NQW8	340..439		44/98 (45%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:Q9NQW8	399..402		1/2 (50%)
		C-linker. /evidence=ECO:0000250|UniProtKB:Q9NQW8	442..518		27/75 (36%)
		Cyclic nucleotide-binding domain. /evidence=ECO:0000250|UniProtKB:Q9NQW8	522..638		61/115 (53%)