DRSC/TRiP Functional Genomics Resources

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Protein Alignment CngB and Kcnh8

DIOPT Version :10

Sequence 1:NP_611607.2 Gene:CngB / 37479 FlyBaseID:FBgn0266346 Length:1040 Species:Drosophila melanogaster
Sequence 2:NP_659563.1 Gene:Kcnh8 / 246325 RGDID:2549 Length:1102 Species:Rattus norvegicus


Alignment Length:851 Identity:179/851 - (21%)
Similarity:308/851 - (36%) Gaps:214/851 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   328 PSINESEIVAV------DEPDTEMNSDVDHRKPSSAGSLDSQGQQFLRDQVR------------H 374
            |..||...|.:      |..||::....:.:|...|......|..|  |..|            |
  Rat   115 PIKNEKGDVVLFLASFKDITDTKVKITSEDKKEDRAKGRSRAGSHF--DSARRRSRAVLYHISGH 177

  Fly   375 LVRRFTARANKVKSRIELPPTPSSSSTVSSPSPPPTKSLHPSPQHKVRLVPAGQSPHRGRLFEAD 439
            |.||   ..||:|.        :::..|..|:         .|::||                :|
  Rat   178 LQRR---EKNKLKI--------NNNVFVDKPA---------FPEYKV----------------SD 206

  Fly   440 TPRSN-VWLCSSLCGANNDERTLDPQGKIYISWLCVVSLSFLYNAWVIPLRASF----PFQTKEN 499
            ..:|. :.|..|...|..|             ||  :.|:..|.|..:|....|    ...|..:
  Rat   207 AKKSKFILLHFSTFKAGWD-------------WL--ILLATFYVAVTVPYNVCFIGNEDLSTTRS 256

  Fly   500 TNIWLACDFCADIIYLLDVVFFKHRVMY-------LFEGFWVKNKNLTRKNYMRKLQFKLDLLAL 557
            |.:   .|...:|::::|:: ...|..|       :||...:....:|       ..|.:||:|.
  Rat   257 TTV---SDIAVEILFIIDII-LNFRTTYVSKSGQVIFEARSICIHYVT-------TWFIIDLIAA 310

  Fly   558 LPLELLYFKLGTQAVWLRFPRFFKIQSFWEVFRLLDRVISSPHFVRVAKTLTYMLYMI-HITAAL 621
            ||.:|||....|....:...:..::.....:.:.|||.  |.|...|...|..|..:: |..|.:
  Rat   311 LPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRY--SQHSTIVLTLLMSMFALLAHWMACI 373

  Fly   622 YYAYSDYQGLGQN--RWVFS-----GK------------GHP-----YVRCFAFATKTATSIG-K 661
            :|.....:....:  :|...     ||            |.|     |:....|...:.||:| .
  Rat   374 WYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFG 438

  Fly   662 NPKPERQGEYVFMTVAWLMGVFVFALLIGQIRDIISTATRNKHEYRQLEDETLEYMRRLNLSQEV 726
            |.......|.:|.....|:|..:.||:.|.:..||.........|.....:..:::|..:|.|::
  Rat   439 NVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQL 503

  Fly   727 QSRVKMWFQFTWEQQRTLDESNILDALPINLKTDIAISVHIQTLSKVQLFADCEEALLRDLVLKL 791
            :.|:..:||.||.....:|.:.:|...|..|::||.:.::.:.| ::.||.......||.|.|.:
  Rat   504 KQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEIL-QLSLFECASRGCLRSLSLHI 567

  Fly   792 RAVTFLPGDFVCRKGEVGREMYIVKLGQVQVMGGPSSDVVLATLTEGSVFGEISLLGINGADRRT 856
            :.....||:::.|:|:..:.:|.|..|.::|:   ...:|||.|.:|.:.|  :.|.|.....:|
  Rat   568 KTSFCAPGEYLLRQGDALQAIYFVCSGSMEVL---KDSMVLAILGKGDLIG--ANLSIKDQVIKT 627

  Fly   857 -ADVRSKGYSNLFVLSKSDLNEVIAYY-------------------------------------- 882
             |||::..|.:|..:....|.||:..|                                      
  Rat   628 NADVKALTYCDLQCIILKGLFEVLGLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSTVP 692

  Fly   883 ---PTAQAILKKRARQLMRKNAAREREEERERARSAL--QADVVIGNPKTPETAP----KLLQTV 938
               |.....:|||...::......|.|||...:.|.:  :...|..:.||..:..    .|.|..
  Rat   693 QAEPKGNGSIKKRLPSIVEDEEEEEVEEEETTSLSPIYTRGSSVSHSKKTGSSKSYLGLSLKQLT 757

  Fly   939 IQALPFESPAVVLITRGSKRMR---------RKRQSVQME-----TIVEPKME---VTGAAETQD 986
            ...:||.||..|......|..:         ||.::::::     |...|::.   |.|..:...
  Rat   758 SGTVPFHSPIRVSSANSPKTKQEADPPNHGTRKEKNLKVQLCSLGTAGTPELSPRIVDGIEDGNS 822

  Fly   987 QKGLKT-----------GRCSPDLLSS--------IQQELKSKHKFINLTDSEKALISQSANNSL 1032
            .:..:|           .|.||.|..|        |:.| ::|.: ||..:||...::|..:...
  Rat   823 SEETQTFDFGSEQIRPEPRISPSLGESEIGAAFLFIKAE-ETKQQ-INKLNSEVTTLTQEVSQLG 885

  Fly  1033 EDMKVV 1038
            :||:.:
  Rat   886 KDMRSI 891

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CngBNP_611607.2 PLN03192 411..>891 CDD:215625 116/559 (21%)
CAP_ED 775..889 CDD:237999 33/155 (21%)
Kcnh8NP_659563.1 PAS_9 40..135 CDD:463873 5/19 (26%)
PLN03192 175..>615 CDD:215625 111/507 (22%)
Selectivity filter. /evidence=ECO:0000250 434..439 2/4 (50%)
cNMP-binding domain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00060 551..668 32/121 (26%)
PRK11753 578..>656 CDD:236969 24/82 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 683..744 12/60 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 762..793 8/30 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 818..845 3/26 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 960..983
Blue background indicates that the domain is not in the aligned region.

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