Protein Alignment CngB and KCNH3

DIOPT Version :10

• Sequence 1: NP_611607.2
• Gene: CngB / 37479
• FlyBaseID: FBgn0266346
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: XP_011536387.1
• Gene: KCNH3 / 23416
• HGNCID: 6252
• Length: 1094
• Species: Homo sapiens
• Alignment Length: 611
• Identity: 139/611 - (22%)
• Similarity: 243/611 - (39%)
• Gaps: 108/611 - (17%)

  Fly   415 PSPQHKVRLVPAGQSPHRGRLFEADTPRSNVWLCSSLCGANNDERTLDPQGKIYISWLCVVSLSF 479
            |..:||:.....|:.|:......|...:|...|..  |||            :..:|...:.|:.
Human   185 PKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLH--CGA------------LRATWDGFILLAT 235

  Fly   480 LYNAWVIPL-----RASFPFQTKENTNIWLACDFCADIIYLLDVVFFKHRVMYLFEG----FWVK 535
            ||.|..:|.     .|..|...:...::   ||...:::::||:| ...|..::.:.    |..|
Human   236 LYVAVTVPYSVCVSTAREPSAARGPPSV---CDLAVEVLFILDIV-LNFRTTFVSKSGQVVFAPK 296

  Fly   536 NKNLTRKNYMRKLQFKLDLLALLPLELLY-FKLGTQ--AVWLRFPRFFKIQSFWEVFRLLDRVIS 597
            :..|   :|: ...|.||::|.||.:||: ||:...  |..|:..|..::      .|||.|:..
Human   297 SICL---HYV-TTWFLLDVIAALPFDLLHAFKVNVYFGAHLLKTVRLLRL------LRLLPRLDR 351

  Fly   598 SPHFVRVAKTLTYMLY--MIHITAALYY---------AYSDYQGLGQNRWV-------------- 637
            ...:..|..||...::  :.|..|.:::         :.|:...:|   |:
Human   352 YSQYSAVVLTLLMAVFALLAHWVACVWFYIGQREIESSESELPEIG---WLQELARRLETPYYLV 413

  Fly   638 --------FSGK------------------GHP-----YVRCFAFATKTATSIG-KNPKPERQGE 670
                    .||:                  |.|     |:....||..:.||:| .|.......|
Human   414 GRRPAGGNSSGQSDNCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTE 478

  Fly   671 YVFMTVAWLMGVFVFALLIGQIRDIISTATRNKHEYRQLEDETLEYMRRLNLSQEVQSRVKMWFQ 735
            .:|.....|:|..:.|::.|.:..||......:..|.....:..:|:|...:.:.::.|:..:||
Human   479 KIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQ 543

  Fly   736 FTWEQQRTLDESNILDALPINLKTDIAISVHIQTLSKVQLFADCEEALLRDLVLKLRAVTFLPGD 800
            .||.....:|.:.:|.:||..|:.|||:.:|.:.| ::.||.......||.|.|.||.....||:
Human   544 ATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVL-QLPLFEAASRGCLRALSLALRPAFCTPGE 607

  Fly   801 FVCRKGEVGREMYIVKLGQVQVMGGPSSDVVLATLTEGSVFGEISLLGINGADRRTADVRSKGYS 865
            ::..:|:..:.:|.|..|.::|:.|   ..|||.|.:|.:.| ..|.......:..|||:...|.
Human   608 YLIHQGDALQALYFVCSGSMEVLKG---GTVLAILGKGDLIG-CELPRREQVVKANADVKGLTYC 668

  Fly   866 NLFVLSKSDLNEVIAYYPTAQAILKKRARQLMRKNAAREREEERERARSALQAD-VVIGNPKTPE 929
            .|..|..:.|::.:|.||.......:..|..:..|.. ......|...|:|..| .::...:..|
Human   669 VLQCLQLAGLHDSLALYPEFAPRFSRGLRGELSYNLG-AGGGSAEVDTSSLSGDNTLMSTLEEKE 732

  Fly   930 TAPKLLQTVIQALPFESPAVVLITRG 955
            |..:...||..| |.:.|:..|::.|
Human   733 TDGEQGPTVSPA-PADEPSSPLLSPG 757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngB	NP_611607.2	PLN03192	411..>891	CDD:215625	124/544 (23%)
		CAP_ED	775..889	CDD:237999	33/113 (29%)
KCNH3	XP_011536387.1	PAS_9	40..135	CDD:463873
		PLN03192	227..>646	CDD:215625	101/439 (23%)
		cyc_nuc_ocin	<606..701	CDD:274839	25/98 (26%)