Protein Alignment CngB and cng-2

DIOPT Version :10

• Sequence 1: NP_611607.2
• Gene: CngB / 37479
• FlyBaseID: FBgn0266346
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: NP_001343690.1
• Gene: cng-2 / 190732
• WormBaseID: WBGene00022295
• Length: 819
• Species: Caenorhabditis elegans
• Alignment Length: 718
• Identity: 173/718 - (24%)
• Similarity: 303/718 - (42%)
• Gaps: 107/718 - (14%)

  Fly   259 IAIQRAEELAAATGQVVLPKEEEEEEKSSP-LHQVESQPD--VDEDEQDVQICYNESPELQNEDR 320
            :|:.:|.......|.:.||..:..||...| ...:..:|.  ....|:..||....:.|:..::|
 Worm    49 VAVTQASLSVPRPGILRLPSSDPGEEDPQPSTSSIPHRPSKWATVREKSPQIIGGHAKEVTFQER 113

  Fly   321 NERTQRTPSINESEIVAVDEPDTEMNSDVDHRKPSSAGSLDSQGQQFLRDQVRHLVRRFTARANK 385
            :.:.    .:|:|.           ::..:.||.:..|..:..||:...|.|:..:...|..:..
 Worm   114 HHKL----DLNKSR-----------STSKNRRKSAQNGGAEDPGQKSFSDVVKTAMMLRTWISAM 163

  Fly   386 VKSRIELPPTPSSSSTVSSPSPPPTKSLHPSPQHKVRLVPAGQSPHRG--RLFEADTPRSNVWLC 448
            .....|..|...:::|.:..:....:|:.|||       |..|....|  ::.:..|.:     |
 Worm   164 EHDERESEPDRDATTTNAEITAADDRSILPSP-------PIFQQRQTGFTQIKDILTDK-----C 216

  Fly   449 SSLCGANNDERTLDPQGKIYISWLCVVSLSFLYNAWVIPLRASFPFQTKE--NTNIWLACDFCAD 511
            ..|......|.:     ..:..|..::|:..|||.:.:.:   |.|....  ..|.||..:...|
 Worm   217 RKLYYFYVTENS-----TFFYYWTAIISIGILYNMFAMVI---FIFDDVHFGYFNQWLYVNLFFD 273

  Fly   512 IIYLLDVVFFKHRVMYLFEGFWVKNKNLTRKNYMRKLQFKLDLLALLPLELLYFKLGTQAVWLRF 576
            ..:|||.: ...|:.::.||..|...:...|||.:..:.|||||.|.|.: .|..:.|:|..:|.
 Worm   274 FCFLLDCL-VGSRMTFVSEGNEVSQTDKMFKNYRQSRRCKLDLLCLAPAD-FYLFIDTKASLVRA 336

  Fly   577 PRFFKIQSFWEVFRLLDRVISSPHFVRVAKTLTYMLYMIHITAALYYAYSDYQGLGQ---NRWVF 638
            .|..|....:|...|..|....|||:::....:....:.|..|.:|:.:|.||||.:   |.:.|
 Worm   337 IRLVKAYRLYEFIMLTQRRTDFPHFMKILFLTSSCAILFHWNACVYFLFSLYQGLTEDDPNAFGF 401

  Fly   639 S--------------------------------------------------------GKGHPYVR 647
            |                                                        .....|..
 Worm   402 SYYKVFDPRFSICDALYDQDCYYPEDTEVLDIRDERPHYMEDMYKFWDKKFNILQIGNFSREYSM 466

  Fly   648 CFAFATKTATSIGKNPKPERQGEYVFMTVAWLMGVFVFALLIGQIRDIISTATRNKHEYRQLEDE 712
            ...:::.|.|..|:.|.|.:..:........|:||.|||.:||.:..:::..::|.:::|::.|.
 Worm   467 TIYWSSLTITKCGQQPWPSKSSQNSLEIFDTLIGVLVFATIIGGVGSVVTQMSQNVNDFREMMDG 531

  Fly   713 TLEYMRRLNLSQEVQSRVKMWFQFTWEQQRTLDESNILDALPINLKTDIAISVHIQTLSKVQLFA 777
            ...||:...:...:|.||...|.:.....:..||..||..||...:..||.::|..|||||.||.
 Worm   532 IKFYMKYRGVQSAIQDRVLNCFLYLNSHNQLYDEEEILSLLPPFFQARIAANLHQDTLSKVSLFY 596

  Fly   778 DCEEALLRDLVLKLRAVTFLPGDFVCRKGEVGREMYIVKLGQVQVMGGPSSDVVLATLTEGSVFG 842
            .|::.||:::|:.::...:.|.|::|||.|..:||:|||.|.:.|: ...:.|.|.:|.||..||
 Worm   597 KCDQRLLQEVVMLVKQQVYSPNDYLCRKNEKAKEMFIVKKGLLAVI-DDDTGVELDSLKEGHTFG 660

  Fly   843 EISLLGING---ADRRTADVRSKGYSNLFVLSKSDLNEVIAYYPTAQAILKKRARQLMRKNAARE 904
            |:|::.:.|   .|||:..:||.|||:::||.:.|:..::..||..:..|.:.||:::......|
 Worm   661 ELSIVQVKGNILGDRRSVSLRSVGYSDVYVLHQDDVTRLLQEYPEERVRLMENARRMLHSRGLLE 725

  Fly   905 REE 907
            ..|
 Worm   726 TNE 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngB	NP_611607.2	PLN03192	411..>891	CDD:215625	142/545 (26%)
		CAP_ED	775..889	CDD:237999	42/116 (36%)
cng-2	NP_001343690.1	Ion_trans	232..>407	CDD:459842	51/179 (28%)
		PLN03192	<457..>713	CDD:215625	80/256 (31%)
		CAP_ED	594..711	CDD:237999	42/117 (36%)