Protein Alignment CngB and Kcnh3

DIOPT Version :10

• Sequence 1: NP_611607.2
• Gene: CngB / 37479
• FlyBaseID: FBgn0266346
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: XP_006520546.1
• Gene: Kcnh3 / 16512
• MGIID: 1341723
• Length: 1101
• Species: Mus musculus
• Alignment Length: 622
• Identity: 139/622 - (22%)
• Similarity: 241/622 - (38%)
• Gaps: 119/622 - (19%)

  Fly   415 PSPQHKVRLVPAGQSPHRGRLFEADTPRSNVWLCSSLCGANNDERTLDPQGKIYISWLCVVSLSF 479
            |..:||:.....|:.|:......|...:|...|..  |||            :..:|...:.|:.
Mouse   191 PKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLH--CGA------------LRATWDGFILLAT 241

  Fly   480 LYNAWVIPL-----RASFPFQTKENTNIWLACDFCADIIYLLDVVFFKHRVMYLFEG----FWVK 535
            ||.|..:|.     .|..|...:...::   ||...:::::||:| ...|..::.:.    |..|
Mouse   242 LYVAVTVPYSVCVSTAREPSAARGPPSV---CDLAVEVLFILDIV-LNFRTTFVSKSGQVVFAPK 302

  Fly   536 NKNLTRKNYMRKLQFKLDLLALLPLELLY-FKLGTQ--AVWLRFPRFFKIQSFWEVFRLLDRVIS 597
            :..|   :|: ...|.||::|.||.:||: ||:...  |..|:..|..::      .|||.|:..
Mouse   303 SICL---HYV-TTWFLLDVIAALPFDLLHAFKVNVYVGAHLLKTVRLLRL------LRLLPRLDR 357

  Fly   598 SPHFVRVAKTLTYMLY--MIHITAALYY---------AYSDYQGLGQNRWV-------------- 637
            ...:..|..||...::  :.|..|.:::         :.|:...:|   |:
Mouse   358 YSQYSAVVLTLLMAVFALLAHWVACVWFYIGQQEIESSESELPEIG---WLQELARRLETPYYLV 419

  Fly   638 ---------------------FSGKG---------------------HPYVRCFAFATKTATSIG 660
                                 .||.|                     ..|:....||..:.||:|
Mouse   420 SRSPDGGNSSGQSENCSSSSSSSGSGGGRGSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVG 484

  Fly   661 -KNPKPERQGEYVFMTVAWLMGVFVFALLIGQIRDIISTATRNKHEYRQLEDETLEYMRRLNLSQ 724
             .|.......|.:|.....|:|..:.|::.|.:..||......:..|.....:..:|:|...:.:
Mouse   485 FGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPK 549

  Fly   725 EVQSRVKMWFQFTWEQQRTLDESNILDALPINLKTDIAISVHIQTLSKVQLFADCEEALLRDLVL 789
            .::.|:..:||.||.....:|.:.:|.:||..|:.|||:.:|.:.| ::.||.......||.|.|
Mouse   550 PLKQRMLEYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVL-QLPLFEAASRGCLRALSL 613

  Fly   790 KLRAVTFLPGDFVCRKGEVGREMYIVKLGQVQVMGGPSSDVVLATLTEGSVFGEISLLGINGADR 854
            .||.....||:::..:|:..:.:|.|..|.::|:.|   ..|||.|.:|.:.| ..|.......:
Mouse   614 ALRPAFCTPGEYLIHQGDALQALYFVCSGSMEVLKG---GTVLAILGKGDLIG-CELPQREQVVK 674

  Fly   855 RTADVRSKGYSNLFVLSKSDLNEVIAYYPTAQAILKKRARQLMRKNAAREREEERERARSALQAD 919
            ..|||:...|..|..|..:.|:|.:|.||.......:..|..:..|.. ......|...|:|..|
Mouse   675 ANADVKGLTYCVLQCLQLAGLHESLALYPEFAPRFSRGLRGELSYNLG-AGGVSAEVDTSSLSGD 738

  Fly   920 -VVIGNPKTPETAPKLLQTVIQALPFESPAVVLITRG 955
             .::...:..||..:...||..| |.:.|:..|::.|
Mouse   739 NTLMSTLEEKETDGEQGHTVSPA-PADEPSSPLLSPG 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngB	NP_611607.2	PLN03192	411..>891	CDD:215625	124/555 (22%)
		CAP_ED	775..889	CDD:237999	34/113 (30%)
Kcnh3	XP_006520546.1	PAS_9	40..135	CDD:463873
		PLN03192	233..>668	CDD:215625	102/456 (22%)
		cyc_nuc_ocin	<623..718	CDD:274839	26/98 (27%)