Protein Alignment CngB and Kcnh2

DIOPT Version :10

• Sequence 1: NP_611607.2
• Gene: CngB / 37479
• FlyBaseID: FBgn0266346
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: NP_038597.2
• Gene: Kcnh2 / 16511
• MGIID: 1341722
• Length: 1162
• Species: Mus musculus
• Alignment Length: 1094
• Identity: 215/1094 - (19%)
• Similarity: 372/1094 - (34%)
• Gaps: 329/1094 - (30%)

  Fly    81 FCDTLERHAFMRNVINQQPESTRRYSTPGEKEAQVRRSLEEITKDLKEIEQFVSATEELMQREKE 145
            ||   |...:.|..:.|:|.:......|..:    ||:..:|             .:.|:..|:.
Mouse    48 FC---ELCGYSRAEVMQRPCTCDFLHGPRTQ----RRAAAQI-------------AQALLGAEER 92

  Fly   146 QEQMMYSNKENKC------PSPVKR-----VTYKINAYKAPPRRHRPGSPRFYHSRLYFRNGKIG 199
            :.::.:..|:..|      ..|||.     :.:.:| ::....:...|||
Mouse    93 KVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILN-FEVVMEKDMVGSP--------------- 141

  Fly   200 CVDSTEHQNNVGATHALVKHILHHEKPLVS-----------------------PDSVRRVLEQDS 241
                              .|..:|..|..|                       ..|||    ..|
Mouse   142 ------------------AHDTNHRGPSTSWLASGRAKTFRLKLPALLALTARESSVR----TGS 184

  Fly   242 FEMVPLPGAV---PEIVP-----DPIAIQRAEELAAATGQV--VLPKEEEE----EEKSSPLHQV 292
            ......||||   .::.|     :.:|:   :|::|....|  :.|.||..    ...:||:..:
Mouse   185 MRSAGAPGAVVVDVDLTPAAPSSESLAL---DEVSAMDNHVAGLGPAEERRALVGPGSASPVASI 246

  Fly   293 ESQPDVDEDEQDVQICYNESPELQ--NEDRN------ERT---------QRTPSINESEIV---A 337
            ...              :.||..|  |.|.:      .||         :|..|.::.|.:   |
Mouse   247 RGP--------------HPSPRAQSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGA 297

  Fly   338 VDEPDTEMNSDVDHRKPSSAGSLDSQGQQFLRDQVRHLVRRFTARANKVKSRIELPPTPSSSSTV 402
            :..|....::...|  |..:|.|:|....   |.||:  |..:.......:.::|...|..:|..
Mouse   298 LPPPPRHASTGAMH--PLRSGLLNSTSDS---DLVRY--RTISKIPQITLNFVDLKGDPFLASPT 355

  Fly   403 SSP---SPPPTKSLHPSPQHKVRLVPAGQS--PHRGRLFEADTPRSNVWLCSSLCGANNDERTLD 462
            |..   :|...:..|...:...:::..|..  |.    ::...||.:.|             |:.
Mouse   356 SDREIIAPKIKERTHNVTEKVTQVLSLGADVLPE----YKLQAPRIHRW-------------TIL 403

  Fly   463 PQGKIYISWLCVVSLSFLYNAWVIPLRASFPFQTKEN----TNIWLAC------DFCADIIYLLD 517
            ........|..::.|..:|.|...|..|:|..:..|:    .:...||      |...||::::|
Mouse   404 HYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEDGSQAPDCGYACQPLAVVDLIVDIMFIVD 468

  Fly   518 VVFFKHRVMYL-----------------FEGFWVKNKNLTRKNYMRKLQFKLDLLALLPLELLYF 565
            :: ...|..|:                 |:| |                |.:|::|.:|.:||.|
Mouse   469 IL-INFRTTYVNANEEVVSHPGRIAVHYFKG-W----------------FLIDMVAAIPFDLLIF 515

  Fly   566 KLGTQAV--WLRFPRFFKIQSFWEVFRLLDRVISSPHFVRVAKTLTYMLYMIHITAALYYAYSDY 628
            ..|::.:  .|:..|..::.   .|.|.|||.......|......|:.| :.|..|.::||..:.
Mouse   516 GSGSEELIGLLKTARLLRLV---RVARKLDRYSEYGAAVLFLLMCTFAL-IAHWLACIWYAIGNM 576

  Fly   629 Q------------GLGQ---NRWVFSGKGHP-----YVRCFAFATKTATSIG-KNPKPERQGEYV 672
            :            .||.   ..:..||.|.|     ||....|...:.||:| .|..|....|.:
Mouse   577 EQPHMDSHIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKI 641

  Fly   673 FMTVAWLMGVFVFALLIGQIRDIISTATRNKHEYRQLEDETLEYMRRLNLSQEVQSRVKMWFQFT 737
            |.....|:|..::|.:.|.:..||.........|........|::|...:...::.|::.:||..
Mouse   642 FSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHA 706

  Fly   738 WEQQRTLDESNILDALPINLKTDIAISVHIQTLSKVQLFADCEEALLRDLVLKLRAVTFLPGDFV 802
            |.....:|.:.:|...|..|:.||.:.::...|...:.|....:..||.|.:|.:.....|||.:
Mouse   707 WSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTL 771

  Fly   803 CRKGEVGREMYIVKLGQVQVMGGPSSDVVLATLTEGSVFGE-ISLLGINGADRRTADVRSKGYSN 866
            ...|::...:|.:..|.::::.|   |||:|.|.:..:||| ::|....|  :...|||:..|.:
Mouse   772 VHAGDLLTALYFISRGSIEILRG---DVVVAILGKNDIFGEPLNLYARPG--KSNGDVRALTYCD 831

  Fly   867 LFVLSKSDLNEVIAYYP-------------------------TAQAILKKR-ARQLMRKNAARER 905
            |..:.:.||.||:..||                         ...|.|:.. .||..||.:.|.|
Mouse   832 LHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSAELESGFNRQRKRKLSFRRR 896

  Fly   906 ---EEERERARSAL-QADVVIG-------------------NPKTPETA----PKLLQTVIQALP 943
               :.|:....||| |....:|                   .|.:||::    |....:.::.:|
Mouse   897 TDKDTEQPGEVSALGQGPARVGPGPSCRGQPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVP 961

  Fly   944 FESPAVVLITRGSKRMRRKRQSVQMETIVEPKMEVTGAAETQDQKGLKTGRCSP 997
            |.||                         .|..:..| .|...:.|.|:..|:|
Mouse   962 FSSP-------------------------RPPGDPPG-GEPLTEDGEKSDTCNP 989

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngB	NP_611607.2	PLN03192	411..>891	CDD:215625	119/557 (21%)
		CAP_ED	775..889	CDD:237999	34/139 (24%)
Kcnh2	NP_038597.2	PRK13559	30..328	CDD:237427	61/359 (17%)
		PAS_9	38..130	CDD:463873	18/102 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	233..316		16/98 (16%)
		Ion_trans	411..670	CDD:459842	63/280 (23%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:Q63472	626..631		2/4 (50%)
		CAP_ED	744..855	CDD:237999	33/115 (29%)
		cNMP-binding domain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00060	744..844		30/104 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	873..991		29/143 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1125..1162