DRSC/TRiP Functional Genomics Resources

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Protein Alignment CngB and Hcn2

DIOPT Version :10

Sequence 1:NP_611607.2 Gene:CngB / 37479 FlyBaseID:FBgn0266346 Length:1040 Species:Drosophila melanogaster
Sequence 2:NP_032252.1 Gene:Hcn2 / 15166 MGIID:1298210 Length:863 Species:Mus musculus


Alignment Length:735 Identity:158/735 - (21%)
Similarity:273/735 - (37%) Gaps:189/735 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   393 PPTPSSSSTVSSPSPPPTKSLHP-SPQHKVRLVPAGQSPHRGRLFEADTPRSNVWLCS--SLC-- 452
            ||.|........|.|||....:| :|.|          |.     .||.|.....|||  |.|  
Mouse    22 PPPPPPPPAPPQPQPPPAPPPNPTTPSH----------PE-----SADEPGPRARLCSRDSACTP 71

  Fly   453 -----GANND----ERTLDPQG-----KIYISWLCVVS-----------------------LSFL 480
                 |||.:    |....|:|     |:..|.....|                       .|||
Mouse    72 GAAKGGANGECGRGEPQCSPEGPARGPKVSFSCRGAASGPSAAEEAGSEEAGPAGEPRGSQASFL 136

  Fly   481 Y-----------------------------------NAWVIPLRASFPFQ--------------- 495
            .                                   .||:|...:.|.|.               
Mouse   137 QRQFGALLQPGVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLII 201

  Fly   496 --------TKENTNIWLACDFCADIIYLLDVVF-FKHRVMYLFEGFWVKNKNLTRKNYMRKLQFK 551
                    ..|.|..|:..:..:|..:|:|:|. |:..::.......:.:....:|.|:| ..|.
Mouse   202 IPVGITFFKDETTAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLR-TWFV 265

  Fly   552 LDLLALLPLELLYF--------KLGTQAVWLRFPRFFKIQSFWEVFRLLDRVISSPH-------- 600
            :|.::.:|::.::.        ::...|..||..||.||.|...:.| |.|:|...|        
Mouse   266 VDFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLR-LSRLIRYIHQWEEIFHM 329

  Fly   601 -------FVRVAKTLTYMLYMIHITAALYYAYSDYQGLGQNRWVFSGK--GHPYVRCFAFATKTA 656
                   .:|:...::.||.:.|....|.:.....|....:.||....  .|.:...::||...|
Mouse   330 TYDLASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPSDCWVSINNMVNHSWSELYSFALFKA 394

  Fly   657 TS----IGKNPK-PERQGEYVFMTVAWLMGVFVFALLIGQIRDIISTATRNKHEYRQLEDETLEY 716
            .|    ||...: ||...:.....::.::|...:|:.||....:|.:...::.:|::...:..:|
Mouse   395 MSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQY 459

  Fly   717 MRRLNLSQEVQSRVKMWFQFTWEQQRTLDESNILDALPINLKTDIAISVHIQTLSKVQLFADCEE 781
            |....|..:.:.::..:::..: |.:..||.:||..|...|:.:|......:.::.:.|||:.:.
Mouse   460 MSFHKLPADFRQKIHDYYEHRY-QGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADP 523

  Fly   782 ALLRDLVLKLRAVTFLPGDFVCRKGEVGREMYIVKLGQVQVMGGPSSDVVLATLTEGSVFGEISL 846
            ..:..::.||:...|.|||::.|:|.:|::||.::.|.|.|:...:.::   .|::||.||||.|
Mouse   524 NFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEM---KLSDGSYFGEICL 585

  Fly   847 LGINGADRRTADVRSKGYSNLFVLSKSDLNEVIAYYP----TAQAILKKRARQLMRKNAA----- 902
            |   ...||||.||:..|..|:.||..:.|||:..||    ..:.:...|..::.:||:.     
Mouse   586 L---TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKV 647

  Fly   903 ---------REREE---------ERERARSA-LQADVVIGNPKTPETAPKLLQTVIQALPFE--- 945
                     ..:|.         :||..:.| |...|.:..|..|......:.|:.||:...   
Mouse   648 QHDLSSGVFNNQENAIIQEIVKYDREMVQQAELGQRVGLFPPPPPPQVTSAIATLQQAVAMSFCP 712

  Fly   946 ---SPAVVLITRGSKRMRRK 962
               .|.|..:..||.|:.|:
Mouse   713 QVARPLVGPLALGSPRLVRR 732

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CngBNP_611607.2 PLN03192 411..>891 CDD:215625 131/614 (21%)
CAP_ED 775..889 CDD:237999 41/117 (35%)
Hcn2NP_032252.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..131 28/123 (23%)
Involved in subunit assembly 131..182 6/50 (12%)
Ion_trans_N 140..182 CDD:400630 3/41 (7%)
PLN03192 175..>661 CDD:215625 109/494 (22%)
CAP_ED 517..625 CDD:237999 41/113 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 730..863 1/3 (33%)
PRK07003 <769..>862 CDD:235906
Blue background indicates that the domain is not in the aligned region.

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