Protein Alignment CngB and CNGA4

DIOPT Version :10

• Sequence 1: NP_611607.2
• Gene: CngB / 37479
• FlyBaseID: FBgn0266346
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: XP_016872706.1
• Gene: CNGA4 / 1262
• HGNCID: 2152
• Length: 577
• Species: Homo sapiens
• Alignment Length: 620
• Identity: 192/620 - (30%)
• Similarity: 310/620 - (50%)
• Gaps: 83/620 - (13%)

  Fly   410 TKSLHPSPQHKVRLVPAGQSPHRGRLFEADTPRSNVWLCSSLCGANNDERTLDPQGKIYISWLCV 474
            |:|..|:|....:|:|                                  .|||.|..|..||..
Human    10 TESSPPAPSKARKLLP----------------------------------VLDPSGDYYYWWLNT 40

  Fly   475 VSLSFLYNAWVIPLRASFPFQTKENTNIWLACDFCADIIYLLDVVFFKHRVMYLFEGFWVKNKNL 539
            :....:||..::..||.||.........||..|:.:|::||||:|...| ..:|.:|..|.:|..
Human    41 MVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMVVRFH-TGFLEQGILVVDKGR 104

  Fly   540 TRKNYMRKLQFKLDLLALLPLELLYFKLGTQAVWLRFPRFFKIQSFWEVFRLLDRVISSPHFVRV 604
            ....|:|...|.|||.:|:|.:::|.:||.....||..||.:....:|.|...:...:.|:..|:
Human   105 ISSRYVRTWSFFLDLASLMPTDVVYVRLGPHTPTLRLNRFLRAPRLFEAFDRTETRTAYPNAFRI 169

  Fly   605 AKTLTYMLYMIHITAALYYAYSDYQGLGQNRWVFSGKGHP--------YVRCFAFATKTATSIGK 661
            ||.:.|:..:||..:.||:|.|.|.|.|::.||:.....|        |:..|.|:|...|::|.
Human   170 AKLMLYIFVVIHWNSCLYFALSRYLGFGRDAWVYPDPAQPGFERLRRQYLYSFYFSTLILTTVGD 234

  Fly   662 NPKPERQGEYVFMTVAWLMGVFVFALLIGQIRDIISTATRNKHEYRQLEDETL--EYMRRLNLSQ 724
            .|.|.|:.||:||...:|:.|..||.::|.:..:|  ...|..:.....|..|  :||:..::::
Human   235 TPPPAREEEYLFMVGDFLLAVMGFATIMGSMSSVI--YNMNTADAAFYPDHALVKKYMKLQHVNR 297

  Fly   725 EVQSRVKMWFQFTWEQQRTLDESNILDALPINLKTDIAISVHIQTLSKVQLFADCEEALLRDLVL 789
            :::.||..|:|.....::..:|..||..||..|:.::|:|||:.|||:||:|.:||.:||.:|||
Human   298 KLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVL 362

  Fly   790 KLRAVTFLPGDFVCRKGEVGREMYIVKLGQVQVMGGPSSDVV--LATLTEGSVFGEISLLGIN-- 850
            ||:..|:.||::|||||::|:||||::.||:.|:   :.|.:  .|.|..|..|||||::.|.
Human   363 KLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVV---ADDGITQYAVLGAGLYFGEISIINIKAT 424

  Fly   851 ---GADRRTADVRSKGYSNLFVLSKSDLNEVIAYYPTAQAILKKRARQLMRKNAAREREEERERA 912
               ..:||||:::|.|||:||.|||.||.||::.||.||.|::::.|:::.|  ..:.:...|.|
Human   425 GNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQTIMEEKGREILLK--MNKLDVNAEAA 487

  Fly   913 RSALQADVVIGNPKTPETAPKL---------LQTVIQAL--PFESPAVVLITRGSKRMRRKRQSV 966
            ..|||          ..|..:|         |||....|  ..||.|:.:..|..:...:.|:..
Human   488 EIALQ----------EATESRLRGLDQQLDDLQTKFARLLAELESSALKIAYRIERLEWQTREWP 542

  Fly   967 QMETIVEPKME---VTGAAETQDQKGLKTGRCSPD 998
            ..|.:.|...|   ..|.::.::.:..:.|...|:
Human   543 MPEDLAEADDEGEPEEGTSKDEEGRASQEGPPGPE 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngB	NP_611607.2	PLN03192	411..>891	CDD:215625	167/496 (34%)
		CAP_ED	775..889	CDD:237999	57/120 (48%)
CNGA4	XP_016872706.1	Ion_trans	34..273	CDD:459842	76/241 (32%)
		CAP_ED	348..466	CDD:237999	57/120 (48%)
		CLZ	466..536	CDD:465160	17/81 (21%)