Protein Alignment CngB and CNGA3

DIOPT Version :10

• Sequence 1: NP_611607.2
• Gene: CngB / 37479
• FlyBaseID: FBgn0266346
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: XP_011508856.1
• Gene: CNGA3 / 1261
• HGNCID: 2150
• Length: 749
• Species: Homo sapiens
• Alignment Length: 717
• Identity: 228/717 - (31%)
• Similarity: 372/717 - (51%)
• Gaps: 87/717 - (12%)

  Fly   315 LQNEDRNERTQRT-----PSINESEIVAVDEPD-TEMNSDVDHRKPSSAGSLD-SQGQQFLRDQV 372
            :|.:.:.|:..|.     |.|..::..|.|..| :||         :.|||.. |.|.|....::
Human    76 IQKKSQPEKVVRAASRGRPLIGWTQWCAEDGGDESEM---------ALAGSPGCSSGPQGRLSRL 131

  Fly   373 RHLVRRFTARANKVKSRIELP---PTPSSSSTVSSPSPPPTKSLHPSPQHKVRLVPAGQSPHRGR 434
            ..|:||:.||  .|..:.:.|   |.....:.:...|         |.:...:.....|.|
Human   132 IFLLRRWAAR--HVHHQDQGPDSFPDRFRGAELKEVS---------SQESNAQANVGSQEP---- 181

  Fly   435 LFEADTPRSNVW---LCSSLCGANNDER---------TLDPQGKIYISWLCVVSLSFLYNAWVIP 487
               ||..|| .|   .|::....|.:|.         .:||...:|..||..::|...||.:::.
Human   182 ---ADRGRS-AWPLAKCNTNTSNNTEEEKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLI 242

  Fly   488 LRASFPFQTKENTNIWLACDFCADIIYLLDVVFFKHRVMYLFEGFWVKNKNLTRKNYMRKLQFKL 552
            .||.|.....|...:||..|:.||::|:|||: .:.|..:|.:|..|.:.|...::|....||||
Human   243 CRACFDELQSEYLMLWLVLDYSADVLYVLDVL-VRARTGFLEQGLMVSDTNRLWQHYKTTTQFKL 306

  Fly   553 DLLALLPLELLYFKLGTQAVWLRFPRFFKIQSFWEVFRLLDRVISSPHFVRVAKTLTYMLYMIHI 617
            |:|:|:|.:|.|.|:||....:||.|..|....:|.|...:...:.|:..|:...:.|:|.:||.
Human   307 DVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHW 371

  Fly   618 TAALYYAYSDYQGLGQNRWVFSGKGHP--------YVRCFAFATKTATSIGKNPKPERQGEYVFM 674
            .|.:|:|.|.:.|.|.:.||:.....|        |:....::|.|.|:||:.|.|.:..||:|:
Human   372 NACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFV 436

  Fly   675 TVAWLMGVFVFALLIGQIRDIISTATRNKHEYRQLEDETLEYMRRLNLSQEVQSRVKMWFQFTWE 739
            .|.:|:||.:||.::|.:..:||....::.|::...|...:||:...:::::::||..||.:.|.
Human   437 VVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWA 501

  Fly   740 QQRTLDESNILDALPINLKTDIAISVHIQTLSKVQLFADCEEALLRDLVLKLRAVTFLPGDFVCR 804
            .::|:||..:|.:||..||.:|||:||:.||.||::|.|||..||.:||||||...|.|||::|:
Human   502 NKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICK 566

  Fly   805 KGEVGREMYIVKLGQVQVMG--GPSSDVVLATLTEGSVFGEISLLGINGA---DRRTADVRSKGY 864
            ||::|:||||:..|::.|:.  |.:..||   |::||.|||||:|.|.|:   :||||::||.||
Human   567 KGDIGKEMYIINEGKLAVVADDGVTQFVV---LSDGSYFGEISILNIKGSKSGNRRTANIRSIGY 628

  Fly   865 SNLFVLSKSDLNEVIAYYPTAQAILKKRARQLMRKNAAREREEERERARSALQADVVIGNPKTPE 929
            |:||.|||.||.|.:..||.|:..|:::.||::.|:...:.|..|..|           :||..|
Human   629 SDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELARAGA-----------DPKDLE 682

  Fly   930 TAPKLLQTVIQALPFESPAVVLITRGSKRMRRKRQSVQMETIVE-------PKMEVTG-AAETQD 986
            ...:.|.:.:..|.... |.:|....:.:|:.|::..|:|:.|:       ...||.| |.:|:|
Human   683 EKVEQLGSSLDTLQTRF-ARLLAEYNATQMKMKQRLSQLESQVKGGGDKPLADGEVPGDATKTED 746

  Fly   987 QK 988
            ::
Human   747 KQ 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngB	NP_611607.2	PLN03192	411..>891	CDD:215625	179/504 (36%)
		CAP_ED	775..889	CDD:237999	60/118 (51%)
CNGA3	XP_011508856.1	Ion_trans	223..465	CDD:459842	79/242 (33%)
		CAP_ED	537..653	CDD:237999	60/118 (51%)
		CLZ	653..722	CDD:465160	17/80 (21%)