Protein Alignment CngB and CNGA1

DIOPT Version :10

• Sequence 1: NP_611607.2
• Gene: CngB / 37479
• FlyBaseID: FBgn0266346
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: XP_005248106.3
• Gene: CNGA1 / 1259
• HGNCID: 2148
• Length: 690
• Species: Homo sapiens
• Alignment Length: 705
• Identity: 212/705 - (30%)
• Similarity: 349/705 - (49%)
• Gaps: 98/705 - (13%)

  Fly   313 PELQNEDRNERTQRTPSINESEIVAVDEPDTEMNSDVDHRKPSSAGSLD---------SQGQQFL 368
            |:::.|.|........|.:|      |:.....:.:.::..|.:.||..         ||.:|:|
Human    25 PDIEKEIRRMENGACSSFSE------DDDSASTSEESENENPHARGSFSYKSLRKGGPSQREQYL 83

  Fly   369 RD-----QVRHLVRRFTARANKVKSRIELPPTPSSSSTVSSPSPPPTKSLHPSPQHKVRLVPAGQ 428
            ..     .|.:...:......|.|.:.|   ..|.|...:.....|.|......:.|.:.....:
Human    84 PGAIALFNVNNSSNKDQEPEEKKKKKKE---KKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSK 145

  Fly   429 SPHRGRLFEADTPRSNVWLCSSLCGANNDER----TLDPQGKIYISWLCVVSLSFLYNAWVIPLR 489
            .                        ...:|:    .:||.|..|.:||..::|..:||..::..|
Human   146 D------------------------KKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMVIAR 186

  Fly   490 ASFPFQTKENTNIWLACDFCADIIYLLDVVFFKHRVMYLFEGFWVKNKNLTRKNYMRKLQFKLDL 554
            |.|.....:....||..|:.:||:||:| :|.:.|..||.:|..||.:......|...||||||:
Human   187 ACFDELQSDYLEYWLILDYVSDIVYLID-MFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDV 250

  Fly   555 LALLPLELLYFKLGTQAVWLRFPRFFKIQSFWEVFRLLDRVISSPHFVRVAKTLTYMLYMIHITA 619
            |:|:|.:|||||||.....:|..|..:....:|.|:..:...:.|:..|::..:.|::.:||..|
Human   251 LSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNA 315

  Fly   620 ALYYAYSDYQGLGQNRWVFSGKGHP--------YVRCFAFATKTATSIGKNPKPERQGEYVFMTV 676
            .::|:.|...|.|.:.||:.....|        ||....::|.|.|:||:.|.|.|..||||:.|
Human   316 CVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVV 380

  Fly   677 AWLMGVFVFALLIGQIRDIISTATRNKHEYRQLEDETLEYMRRLNLSQEVQSRVKMWFQFTWEQQ 741
            .:|:||.:||.::|.|..:||.....:.|::...|...:||...|:|::::.||..||.:.|..:
Human   381 DFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNK 445

  Fly   742 RTLDESNILDALPINLKTDIAISVHIQTLSKVQLFADCEEALLRDLVLKLRAVTFLPGDFVCRKG 806
            :|:||..:|..||..|:.:|||:||:.||.||::|||||..||.:|||||:...:.|||::|:||
Human   446 KTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKG 510

  Fly   807 EVGREMYIVKLGQVQVMG--GPSSDVVLATLTEGSVFGEISLLGINGA---DRRTADVRSKGYSN 866
            ::||||||:|.|::.|:.  |.:..||   |::||.|||||:|.|.|:   :||||:::|.|||:
Human   511 DIGREMYIIKEGKLAVVADDGVTQFVV---LSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSD 572

  Fly   867 LFVLSKSDLNEVIAYYPTAQAILKKRARQLMRK---------NAAREREEERERARSALQADVVI 922
            ||.|||.||.|.:..||.|:.:|:::.:|::.|         ||..:.::..|:....
Human   573 LFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRM------- 630

  Fly   923 GNPKTPETAPKLLQTVIQALPFESPAVVLITRGSKRMRRKRQSVQMETIVEPKME 977
                  |.:..||||..        |.:|....|.:.:.|::..::|..::|.::
Human   631 ------EGSVDLLQTRF--------ARILAEYESMQQKLKQRLTKVEKFLKPLID 671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngB	NP_611607.2	PLN03192	411..>891	CDD:215625	176/496 (35%)
		CAP_ED	775..889	CDD:237999	60/118 (51%)
CNGA1	XP_005248106.3	Ion_trans	165..407	CDD:459842	82/242 (34%)
		CAP_ED	479..595	CDD:237999	60/118 (51%)
		CLZ	595..664	CDD:465160	15/89 (17%)