DRSC/TRiP Functional Genomics Resources

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Protein Alignment CngB and CNGB1

DIOPT Version :10

Sequence 1:NP_611607.2 Gene:CngB / 37479 FlyBaseID:FBgn0266346 Length:1040 Species:Drosophila melanogaster
Sequence 2:NP_001288.3 Gene:CNGB1 / 1258 HGNCID:2151 Length:1251 Species:Homo sapiens


Alignment Length:1090 Identity:329/1090 - (30%)
Similarity:516/1090 - (47%) Gaps:199/1090 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 EPEASASLLKSSPNILENFAYDEFQP-----------------IQTNHPLL----KRMATTPVAQ 61
            :|..|:.:.:..|.:....|.|...|                 :.|..||.    .:.|..|..|
Human   172 QPPKSSEVWRDEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQ 236

  Fly    62 SGSQSSSSSTSSTRKAEPKFCDTLER--HAFMRNVIN-----QQPESTRRYSTPGEKEAQVRRSL 119
            .|||:.:||...||.........|.|  .|..:.|::     |:|:|      ||..:.|....|
Human   237 PGSQAQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDS------PGICDVQTISIL 295

  Fly   120 E--EITKD--LKEIE-QFVSATEELMQREKEQEQMMYSNKENKCPSPVKRVTYKINAYKAPPRRH 179
            .  ::..|  |:|:| .:..|.:::....:..|.:....:|||....:.|...:|...|......
Human   296 PGGQVEPDLVLEEVEPPWEDAHQDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEEEKEDEEEE 360

  Fly   180 RPGSPRFYHSRLYFRNGKIGCVDSTEHQNNVGATHALVKHILHHEKPLVSPDSVRRVLEQDSFEM 244
            .                     :..|.:.....|..|:      :..:||...|.: .|:|    
Human   361 E---------------------EEEEEEEEEEVTEVLL------DSCVVSQVGVGQ-SEED---- 393

  Fly   245 VPLPGAVPEIVPD--------PIAIQRAEELAAATGQVVLPKEEEEEEK---------------- 285
                |..|:...|        ..|.:.|||.|....:.|..:|.|:|.:                
Human   394 ----GTRPQSTSDQKLWEEVGEEAKKEAEEKAKEEAEEVAEEEAEKEPQDWAETKEEPEAEAEAA 454

  Fly   286 SSPLHQVESQPDVDEDEQDVQIC---YNESP----------------------------ELQNED 319
            ||.:...:..|:|..::.|...|   ..|:|                            :|.:||
Human   455 SSGVPATKQHPEVQVEDTDADSCPLMAEENPPSTVLPPPSPAKSDTLIVPSSASGTHRKKLPSED 519

  Fly   320 RNERTQRTPSINESEIVAVDEPDTEMNSDVDHRKPSSAGSLDSQGQQFLRDQVRHLVRRFTARAN 384
            ......:..|..||.:||..:|.|..::|...|..|:|    |.....:.|:::.||:.|..|..
Human   520 DEAEELKALSPAESPVVAWSDPTTPKDTDGQDRAASTA----STNSAIINDRLQELVKLFKERTE 580

  Fly   385 KVKSRIELPPTPSSSSTVSSPSPPPTKSL-HPSPQHKVRLVPAGQSPHRGRLFEADTPRSNVWLC 448
            |||.::   ..|..:|...||.|.|.|.. .|:|..|    ||          ||: |......|
Human   581 KVKEKL---IDPDVTSDEESPKPSPAKKAPEPAPDTK----PA----------EAE-PVEEEHYC 627

  Fly   449 SSLCGANNDE--------RTLDP-QGKIYISWLCVVSLSFLYNAWVIPLRASFPFQTKENTNIWL 504
            ..||......        :::|| ...:|:.||..|.:::.:|.|:||:|.:||:||.:|.:.||
Human   628 DMLCCKFKHRPWKKYQFPQSIDPLTNLMYVLWLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWL 692

  Fly   505 ACDFCADIIYLLDVVFFKHRVMYLFEGFWVKNKNLTRKNYMRKLQFKLDLLALLPLELLYFKLGT 569
            ..|:..|:||.||:..|:.|:.::..|..:.:|...|.||::..:||:|||:||||:.||.|:|.
Human   693 LMDYLCDLIYFLDITVFQTRLQFVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGV 757

  Fly   570 QAVWLRFPRFFKIQSFWEVFRLLDRVISSPHFVRVAKTLTYMLYMIHITAALYYAYSDYQGLGQN 634
            ..: ||.||..|..:|:|....|:.::|..:..||.:|..|:||.:|:.:.|||..|.|||||..
Human   758 NPL-LRLPRCLKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGST 821

  Fly   635 RWVFSGKGHPYVRCFAFATKTATSIGKNPKPERQGEYVFMTVAWLMGVFVFALLIGQIRDIISTA 699
            .||:.|.|:.|:||:.||.||..:||..|.|:...|.||..:.:..|||.|:::|||:||::..|
Human   822 HWVYDGVGNSYIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAA 886

  Fly   700 TRNKHEYRQLEDETLEYMRRLNLSQEVQSRVKMWFQFTWEQQRTLDESNILDALPINLKTDIAIS 764
            |..:..||...|.|::||....:.:.||:|||.|:::||..|..||||.::..||..::.|:||.
Human   887 TAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAID 951

  Fly   765 VHIQTLSKVQLFADCEEALLRDLVLKLRAVTFLPGDFVCRKGEVGREMYIVKLGQVQVMGGPSSD 829
            |:...:|||.||..|:..::.|::.:||:|.:||.|:||:|||:||||||::.|||||:|||...
Human   952 VNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGK 1016

  Fly   830 VVLATLTEGSVFGEISLLGINGADRRTADVRSKGYSNLFVLSKSDLNEVIAYYPTAQAILKKRAR 894
            .||.||..||||||||||.:.|.:||||:|.:.|::|||:|.|.||||::.:||.:|.:|:|:||
Human  1017 SVLVTLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKAR 1081

  Fly   895 QLMRKNAAREREEERERARSALQADVVIGNPKTPETAPKLLQTVIQALPFESPAVVLIT-----R 954
            :::|.|  .:.:||:         .|:|..|:.  ..|||..           |.:.:|     :
Human  1082 RMLRSN--NKPKEEK---------SVLILPPRA--GTPKLFN-----------AALAMTGKMGGK 1122

  Fly   955 GSK-----RMR-RKRQSVQMETIVEPKMEVTGAAETQDQKGLKTGRCSPD 998
            |:|     .:| |.::...:|...:.:..|..|..:||.|| :.|..:||
Human  1123 GAKGGKLAHLRARLKELAALEAAAKQQELVEQAKSSQDVKG-EEGSAAPD 1171

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CngBNP_611607.2 PLN03192 411..>891 CDD:215625 201/489 (41%)
CAP_ED 775..889 CDD:237999 62/113 (55%)
CNGB1NP_001288.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..75
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 121..151
PRK10263 <167..>311 CDD:236669 33/144 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 172..252 19/79 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 314..561 51/286 (18%)
Calmodulin-binding CaM1. /evidence=ECO:0000250|UniProtKB:Q28181 557..567 2/13 (15%)
IQ-like 568..578 3/9 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 585..619 13/50 (26%)
PLN03192 648..>1034 CDD:215625 167/386 (43%)
Ion conduction pathway. /evidence=ECO:0000305|PubMed:34699778 786..885 43/98 (44%)
C-linker. /evidence=ECO:0000305|PubMed:34699778 888..964 29/75 (39%)
CAP_ED 962..1071 CDD:237999 60/108 (56%)
Cyclic nucleotide-binding domain. /evidence=ECO:0000305|PubMed:34699778, ECO:0007744|PDB:7RHI 968..1084 63/115 (55%)
Calmodulin-binding CaM2. /evidence=ECO:0000250|UniProtKB:Q28181 1148..1154 1/5 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1151..1251 9/22 (41%)
Blue background indicates that the domain is not in the aligned region.

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