DRSC/TRiP Functional Genomics Resources

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Protein Alignment CngB and Kcnh2

DIOPT Version :10

Sequence 1:NP_611607.2 Gene:CngB / 37479 FlyBaseID:FBgn0266346 Length:1040 Species:Drosophila melanogaster
Sequence 2:NP_446401.1 Gene:Kcnh2 / 117018 RGDID:621414 Length:1163 Species:Rattus norvegicus


Alignment Length:899 Identity:187/899 - (20%)
Similarity:318/899 - (35%) Gaps:226/899 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   169 INAYKAPPRRHRPGSPRFYHSRLYFRNGKIGC----VDST-----EHQNNVGATHALVKHILHHE 224
            :.|.::|.|....|||           |..|.    ||.|     .....:....|:..|:..  
  Rat   173 LTARESPMRTGSTGSP-----------GAPGAVVVDVDLTPAAPSSESLALDEVSAMDNHVAG-- 224

  Fly   225 KPLVSPDSVRRVLEQDSFEMVPLPGAVPEIVPDPIAIQRAEEL-AAATGQVVLPKEEEEEEKSSP 288
               :.|...||.|      :.|...:....:|.|....||:.| ..|:|...........|..:.
  Rat   225 ---LGPAEERRAL------VGPASASPVASIPGPHPSPRAQSLNPDASGSSCSLARTRSRESCAS 280

  Fly   289 LHQVESQPDVDEDEQDVQICYNESPELQNEDRNERTQRTPSINESEIVAVDEPDTEMNSDVDHRK 353
            :.:..|..|::.         ..:..|....|:..|.....:....:.:..:.|......:....
  Rat   281 VRRASSADDIEA---------MRAGALPLPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIP 336

  Fly   354 PSSAGSLDSQGQQFLRDQV--RHLVRRFTARANKVKSRIELPPTPSSSSTVSSPSPPPTKSLHPS 416
            ..:...:|.:|..||....  |.::      |.|:|.|     |.:.:..|:.     ..||...
  Rat   337 QITLNFVDLKGDPFLASPTSDREII------APKIKER-----THNVTEKVTQ-----VLSLGAD 385

  Fly   417 --PQHKVRLVPAGQSP--HRGRLFEADTPRSNVWLCSSLCGANNDERTLDPQGKIYISWLCVVSL 477
              |::|:      |:|  ||..:... :|...||                       .||  :.|
  Rat   386 VLPEYKL------QAPRIHRWTILHY-SPFKAVW-----------------------DWL--ILL 418

  Fly   478 SFLYNAWVIPLRASFPFQTKEN----TNIWLAC------DFCADIIYLLDVVFFKHRVMYL---- 528
            ..:|.|...|..|:|..:..|:    .:...||      |...||::::|:: ...|..|:    
  Rat   419 LVIYTAVFTPYSAAFLLKETEDGSQAPDCGYACQPLAVVDLLVDIMFIVDIL-INFRTTYVNANE 482

  Fly   529 -------------FEGFWVKNKNLTRKNYMRKLQFKLDLLALLPLELLYFKLGTQAV--WLRFPR 578
                         |:| |                |.:|::|.:|.:||.|..|::.:  .|:..|
  Rat   483 EVVSHPGRIAVHYFKG-W----------------FLIDMVAAIPFDLLIFGSGSEELIGLLKTAR 530

  Fly   579 FFKIQSFWEVFRLLDRVISSPHFVRVAKTLTYMLYMIHITAALYYAYSDYQ------------GL 631
            ..::.   .|.|.|||.......|......|:.| :.|..|.::||..:.:            .|
  Rat   531 LLRLV---RVARKLDRYSEYGAAVLFLLMCTFAL-IAHWLACIWYAIGNMEQPHMDSHIGWLHNL 591

  Fly   632 GQ---NRWVFSGKGHP-----YVRCFAFATKTATSIG-KNPKPERQGEYVFMTVAWLMGVFVFAL 687
            |.   ..:..||.|.|     ||....|...:.||:| .|..|....|.:|.....|:|..::|.
  Rat   592 GDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYAS 656

  Fly   688 LIGQIRDIISTATRNKHEYRQLEDETLEYMRRLNLSQEVQSRVKMWFQFTWEQQRTLDESNILDA 752
            :.|.:..||.........|........|::|...:...::.|::.:||..|.....:|.:.:|..
  Rat   657 IFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKG 721

  Fly   753 LPINLKTDIAISVHIQTLSKVQLFADCEEALLRDLVLKLRAVTFLPGDFVCRKGEVGREMYIVKL 817
            .|..|:.||.:.::...|...:.|....:..||.|.:|.:.....|||.:...|::...:|.:..
  Rat   722 FPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISR 786

  Fly   818 GQVQVMGGPSSDVVLATLTEGSVFGE-ISLLGINGADRRTADVRSKGYSNLFVLSKSDLNEVIAY 881
            |.::::.|   |||:|.|.:..:||| ::|....|  :...|||:..|.:|..:.:.||.||:..
  Rat   787 GSIEILRG---DVVVAILGKNDIFGEPLNLYARPG--KSNGDVRALTYCDLHKIHRDDLLEVLDM 846

  Fly   882 YP-------------------------TAQAILKKR-ARQLMRKNAARER---EEERERARSAL- 916
            ||                         .:.|.|:.. .||..||.:.|.|   :.|:....||| 
  Rat   847 YPEFSDHFWSSLEITFNLRDTNMIPGSPSSAELESGFNRQRKRKLSFRRRTDKDTEQPGEVSALG 911

  Fly   917 QADVVIG-------------------NPKTPETA----PKLLQTVIQALPFESP 947
            |....:|                   .|.:||::    |....:.::.:||.||
  Rat   912 QGPARVGPGPSCRGQPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSP 965

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CngBNP_611607.2 PLN03192 411..>891 CDD:215625 124/559 (22%)
CAP_ED 775..889 CDD:237999 34/139 (24%)
Kcnh2NP_446401.1 PAS_9 38..130 CDD:463873
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 235..286 9/50 (18%)
Ion_trans 411..670 CDD:459842 66/305 (22%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:Q63472 626..631 2/4 (50%)
CAP_ED 744..855 CDD:237999 33/115 (29%)
cNMP-binding domain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00060 744..844 30/104 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 873..992 22/93 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1015..1043
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1126..1163
Blue background indicates that the domain is not in the aligned region.

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