Protein Alignment CngB and Kcnh6

DIOPT Version :10

• Sequence 1: NP_611607.2
• Gene: CngB / 37479
• FlyBaseID: FBgn0266346
• Length: 1040
• Species: Drosophila melanogaster
• Sequence 2: XP_006247617.1
• Gene: Kcnh6 / 116745
• RGDID: 620304
• Length: 971
• Species: Rattus norvegicus
• Alignment Length: 673
• Identity: 151/673 - (22%)
• Similarity: 245/673 - (36%)
• Gaps: 161/673 - (23%)

  Fly   345 MNSDVDHRKPSSAGSLDSQGQQFLRDQVRHLVRRFTARANKVKSRIELPPTPSSSSTVSSPSPPP 409
            :.|:..|.:||..|....:|:.....|:......| ...|..|.|        |.||.......|
  Rat   154 LGSEGSHSRPSGQGPGPGRGKYRTVSQIPQFTLNF-VEFNLEKHR--------SGSTTEIEIIAP 209

  Fly   410 TKSLHPS------------------PQHKVRLVPAGQSP--HRGRLFEADTPRSNVWLCSSLCGA 454
            .|.:..:                  |::|:      |:|  |||.:... :|...||
  Rat   210 HKVVERTQNVTEKVTQVLSLGADVLPEYKL------QAPRIHRGTILHY-SPFKAVW-------- 259

  Fly   455 NNDERTLDPQGKIYISWLCVVSLSFLYNAWVIPLRASFPFQTKENT---NIWLAC------DFCA 510
                           .||  :.|..:|.|...|..|:|....::.:   .....|      |...
  Rat   260 ---------------DWL--ILLLVIYTAVFTPYSAAFLLSDQDESQRGTCGYTCSPLTVVDLIV 307

  Fly   511 DIIYLLDVVFFKHRVMYLFEGFWVKNKNLTRKNYMRKLQ-------FKLDLLALLPLELLYFKLG 568
            ||::::|:| ...|..|:       |.|....::.|::.       |.:|::|.:|.:||.|:.|
  Rat   308 DIMFVVDIV-INFRTTYV-------NTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTG 364

  Fly   569 TQAV-----WLRFPRFFKIQSFWEVFRLLDRVISSPHFVRVAKTLTYMLYMIHITAALYYAYSDY 628
            :...     .|:..|..::.   .|.|.|||.......|......|:.| :.|..|.::||..:.
  Rat   365 SDETTTLIGLLKTARLLRLV---RVARKLDRYSEYGAAVLFLLMCTFAL-IAHWLACIWYAIGNV 425

  Fly   629 Q------GLGQNRWVFS-----GKGH-------------PYVRCFAFATKTATSIG-KNPKPERQ 668
            :      .:|   |:.|     ||.:             .||....|...:.||:| .|..|...
  Rat   426 ERPYLEPKIG---WLDSLGAQLGKQYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTN 487

  Fly   669 GEYVFMTVAWLMGVFVFALLIGQIRDIISTATRNKHEYRQLEDETLEYMRRLNLSQEVQSRVKMW 733
            .|.||.....|:|..::|.:.|.:..||.........|........|::|...:...::.|::.:
  Rat   488 SEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEY 552

  Fly   734 FQFTWEQQRTLDESNILDALPINLKTDIAISVHIQTLSKVQLFADCEEALLRDLVLKLRAVTFLP 798
            ||..|.....:|.:.:|...|..|:.||.:.:|...|.....|....:..||.|.:|.:.....|
  Rat   553 FQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFRGASKGCLRALAVKFKTTHAPP 617

  Fly   799 GDFVCRKGEVGREMYIVKLGQVQVMGGPSSDVVLATLTEGSVFGEISLLGINGADRRTADVRSKG 863
            ||.:...|:|...:|.:..|.::::   ..|||:|.|.:..:|||.:.|... ..:.:||||:..
  Rat   618 GDTLVHLGDVLSTLYFISRGSIEIL---RDDVVVAILGKNDIFGEPASLHAR-PGKSSADVRALT 678

  Fly   864 YSNLFVLSKSDLNEVIAYYPT-AQAILKK------------------RARQLMRKNAAREREEER 909
            |.:|..:.::||.||:..||. |.....|                  .|..||.|...||
  Rat   679 YCDLHKIHRADLLEVLDMYPAFADTFWNKLEVTFNLRDSCPLHVILLMAIILMNKPTTRE----- 738

  Fly   910 ERARSALQADVVIGNPKTPETAP 932
               ...||:        ||..||
  Rat   739 ---DGGLQS--------TPRQAP 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngB	NP_611607.2	PLN03192	411..>891	CDD:215625	123/546 (23%)
		CAP_ED	775..889	CDD:237999	34/114 (30%)
Kcnh6	XP_006247617.1	PAS_9	38..132	CDD:463873
		PLN03192	259..>698	CDD:215625	110/482 (23%)