DRSC/TRiP Functional Genomics Resources

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Protein Alignment CngB and HCN4

DIOPT Version :10

Sequence 1:NP_611607.2 Gene:CngB / 37479 FlyBaseID:FBgn0266346 Length:1040 Species:Drosophila melanogaster
Sequence 2:NP_005468.1 Gene:HCN4 / 10021 HGNCID:16882 Length:1203 Species:Homo sapiens


Alignment Length:820 Identity:183/820 - (22%)
Similarity:320/820 - (39%) Gaps:169/820 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   276 LPKEEEEEEKSSPLHQVESQPDVDEDEQDVQICYNESPELQNEDRNERTQR-------TPSI--- 330
            ||....:...|.| .||.::..:.::|:|.:    |......:|.:.|:.|       :||.   
Human     4 LPPSMRKRLYSLP-QQVGAKAWIMDEEEDAE----EEGAGGRQDPSRRSIRLRPLPSPSPSAAAG 63

  Fly   331 -NESEIVAVDEPDTE----------MNSDVDHRKPSSAGSLDSQG-----------QQFLRDQVR 373
             .||...|:...|:|          .|.|. .|...|..||.|:|           ...|.|...
Human    64 GTESRSSALGAADSEGPARGAGKSSTNGDC-RRFRGSLASLGSRGGGSGGTGSGSSHGHLHDSAE 127

  Fly   374 HLVRRFTARANKVKSRIELPP-------TPSSSSTVSSPSPPPTKSLHPS--------------- 416
            .  ||..|..:........||       .|.:|:..::..|||.:...|:               
Human   128 E--RRLIAEGDASPGEDRTPPGLAAEPERPGASAQPAASPPPPQQPPQPASASCEQPSVDTAIKV 190

  Fly   417 -----------PQHKVRLVPAGQSPHR-GRLFEADTPRSNVWLCSSLCGANNDER--------TL 461
                       |:.:|||..||....: |.:.:....:.::.:..|......::.        .:
Human   191 EGGAAAGDQILPEAEVRLGQAGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWII 255

  Fly   462 DPQGKIYISWLCVVSLSFLYNAWVIPLRASFPFQTKENTNIWLACDFCADIIYLLDVVF-FKHRV 525
            .|.......|...:.|..:.|..:||:..:| |: .|||..|:..:..:|..:|:|:|. |:..:
Human   256 HPYSDFRFYWDLTMLLLMVGNLIIIPVGITF-FK-DENTTPWIVFNVVSDTFFLIDLVLNFRTGI 318

  Fly   526 MYLFEGFWVKNKNLTRKNYMRKLQFKLDLLALLPLELLYFKLGTQ--------AVWLRFPRFFKI 582
            :.......:.:....:..|: |..|.:|.::.:|::.::..:.|:        |..||..||.||
Human   319 VVEDNTEIILDPQRIKMKYL-KSWFMVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKI 382

  Fly   583 QSFWEVFRLLDRVISSPH---------------FVRVAKTLTYMLYMIHITAALYYAYSDYQGLG 632
            .|...:.| |.|:|...|               .||:...:..||.:.|....|.:.....|...
Human   383 LSLLRLLR-LSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFP 446

  Fly   633 QNRWVFS--------GKGHPYVRCFAFATKTATSIGKNPKPERQGEYVFMTVAWL------MGVF 683
            .:.||..        ||.:.|....|.:.......|:...       |.|:..||      :|..
Human   447 DDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAP-------VGMSDVWLTMLSMIVGAT 504

  Fly   684 VFALLIGQIRDIISTATRNKHEYRQLEDETLEYMRRLNLSQEVQSRVKMWFQFTWEQQRTLDESN 748
            .:|:.||....:|.:...::.:|::...:..:||....|..:.:.|:..:::..: |.:..||.:
Human   505 CYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRY-QGKMFDEES 568

  Fly   749 ILDALPINLKTDIAISVHIQTL-SKVQLFADCEEALLRDLVLKLRAVTFLPGDFVCRKGEVGREM 812
            ||..|...|:.:| |:.:.:.| :.:.|||:.:...:..::.|||...|.|||::.|:|.:|::|
Human   569 ILGELSEPLREEI-INFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKM 632

  Fly   813 YIVKLGQVQVMGGPSSDVVLATLTEGSVFGEISLLGINGADRRTADVRSKGYSNLFVLSKSDLNE 877
            |.::.|.|.|:...:.:..||   :||.||||.||   ...||||.||:..|..|:.||..:.||
Human   633 YFIQHGVVSVLTKGNKETKLA---DGSYFGEICLL---TRGRRTASVRADTYCRLYSLSVDNFNE 691

  Fly   878 VIAYYP----TAQAILKKRARQLMRKNAA----------------RERE-------EERERARSA 915
            |:..||    ..:.:...|..::.:||:.                :|.|       .:||.|..|
Human   692 VLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQIVQHDREMAHCA 756

  Fly   916 --LQADVVIGNPKTPETAPKLLQTVIQALPFESPAVVLIT 953
              :||........||.....|:|..:||....:...:.:|
Human   757 HRVQAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALT 796

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CngBNP_611607.2 PLN03192 411..>891 CDD:215625 126/557 (23%)
CAP_ED 775..889 CDD:237999 43/117 (37%)
HCN4NP_005468.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..182 40/185 (22%)
Involved in subunit assembly. /evidence=ECO:0000250 209..260 5/50 (10%)
Ion_trans_N 218..260 CDD:400630 3/41 (7%)
PLN03192 253..>740 CDD:215625 121/505 (24%)
CAP_ED 595..703 CDD:237999 43/113 (38%)
PHA03247 <766..1044 CDD:223021 7/31 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 836..856
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 870..897
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 918..1203
PHA03247 <928..1200 CDD:223021
Blue background indicates that the domain is not in the aligned region.

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