Protein Alignment CG10307 and PHLPP1

DIOPT Version :10

• Sequence 1: NP_611605.1
• Gene: CG10307 / 37477
• FlyBaseID: FBgn0034655
• Length: 341
• Species: Drosophila melanogaster
• Sequence 2: NP_919431.2
• Gene: PHLPP1 / 23239
• HGNCID: 20610
• Length: 1717
• Species: Homo sapiens
• Alignment Length: 406
• Identity: 93/406 - (22%)
• Similarity: 149/406 - (36%)
• Gaps: 116/406 - (28%)

  Fly    27 SLNLSHYQISDVPGIIEKCETLMKLFLNQNKLTKIPS-----SIGSLMR---LQVLTLDYNKLDE 83
            |::||...:..:|..:...:.|..|.|.||.|.:.||     .:..|.|   |:.|.|..|.|.:
Human   641 SVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGD 705

  Fly    84 FPLCICRLVRLKFLNISCNNISSLPPELGYLTQLETFWCNNTGLLELPNEIRNCEHLETLGVRGN 148
            |||.:|.:..|..||:|||.:.|:|..:|.:..|:||..:...|..||.|:.|.:.|..||:..|
Human   706 FPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFN 770

  Fly   149 PLKKLPDAIGALSSLRWLTAEG------------------------------------------- 170
            ....:|:.:..|:::..|...|
Human   771 EFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQ 835

  Fly   171 -----------------------CELSEVPLTMALLG-----------------------NLVHL 189
                                   ||.::: :|:.:.|                       .|.::
Human   836 LDLRDNKLGDLDAMIFNNIEVLHCERNQL-VTLDICGYFLKALYASSNELVQLDVYPVPNYLSYM 899

  Fly   190 NLKGNRLRRLPRMLMAMQKLRFAFLNENCIDEMPTR----SQLEELRTLHMLNLSKNPISLHRDL 250
            ::..|||..:|..:...:||....:..|.|.|:|.|    |.|.:|...|. .|::.|..|.|..
Human   900 DVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHN-QLARLPERLERTS 963

  Fly   251 QLMALRQTNLYVELPSDPANICDGLASRASLNAQEQQEDQARGAGQDLDSSDWANSVRTSELDTT 315
            ..:...|.|..:|||.:.....|.|   ..|||...:.:....|    ..|:..||: ..||..|
Human   964 VEVLDVQHNQLLELPPNLLMKADSL---RFLNASANKLESLPPA----TLSEETNSI-LQELYLT 1020

  Fly   316 DESALENNIEDLSVML 331
            :     |::.|..|.|
Human  1021 N-----NSLTDKCVPL 1031

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10307	NP_611605.1	leucine-rich repeat	27..44	CDD:275380	4/16 (25%)
		LRR	<39..>276	CDD:443914	75/337 (22%)
		leucine-rich repeat	48..70	CDD:275380	9/26 (35%)
		leucine-rich repeat	71..93	CDD:275380	9/21 (43%)
		leucine-rich repeat	94..116	CDD:275380	9/21 (43%)
		leucine-rich repeat	117..139	CDD:275380	8/21 (38%)
		leucine-rich repeat	140..162	CDD:275380	6/21 (29%)
		leucine-rich repeat	163..185	CDD:275380	6/110 (5%)
		leucine-rich repeat	186..208	CDD:275380	5/21 (24%)
		leucine-rich repeat	209..233	CDD:275380	9/27 (33%)
PHLPP1	NP_919431.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25
		PRK07764	<2..444	CDD:236090
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	41..118
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	136..156
		Ubl1_cv_Nsp3_N-like	202..>244	CDD:475130
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	252..470
		PHA03247	<273..444	CDD:223021
		RA_PHLPP1	<471..528	CDD:340760
		PH_PHLPP-like	535..631	CDD:270131
		LRR	<637..898	CDD:443914	53/257 (21%)
		LRR 1	638..659		4/17 (24%)
		leucine-rich repeat	641..661	CDD:275380	4/19 (21%)
		LRR 2	661..682		8/20 (40%)
		leucine-rich repeat	662..692	CDD:275380	10/29 (34%)
		LRR 3	692..712		8/19 (42%)
		leucine-rich repeat	693..738	CDD:275380	18/44 (41%)
		LRR 4	715..736		9/20 (45%)
		LRR 5	738..760		8/21 (38%)
		leucine-rich repeat	739..761	CDD:275380	8/21 (38%)
		LRR 6	761..783		5/21 (24%)
		leucine-rich repeat	762..784	CDD:275380	6/21 (29%)
		LRR 7	784..804		2/19 (11%)
		leucine-rich repeat	785..808	CDD:275380	2/22 (9%)
		LRR 8	808..831		0/22 (0%)
		leucine-rich repeat	810..832	CDD:275380	0/21 (0%)
		LRR 9	832..853		0/20 (0%)
		leucine-rich repeat	833..853	CDD:275380	0/19 (0%)
		leucine-rich repeat	854..895	CDD:275380	4/41 (10%)
		LRR 10	873..894		0/20 (0%)
		LRR 11	895..916		5/20 (25%)
		leucine-rich repeat	896..918	CDD:275380	5/21 (24%)
		LRR 12	918..939		7/20 (35%)
		leucine-rich repeat	919..941	CDD:275380	6/21 (29%)
		LRR 13	941..962		6/21 (29%)
		leucine-rich repeat	942..963	CDD:275380	7/21 (33%)
		LRR	<952..>1154	CDD:443914	25/93 (27%)
		LRR 14	963..984		5/20 (25%)
		leucine-rich repeat	964..987	CDD:275380	5/22 (23%)
		LRR 15	987..1008		5/27 (19%)
		leucine-rich repeat	988..1011	CDD:275380	6/29 (21%)
		LRR 16	1013..1033		7/25 (28%)
		leucine-rich repeat	1014..1037	CDD:275380	7/23 (30%)
		LRR 17	1037..1058
		leucine-rich repeat	1038..1061	CDD:275380
		LRR 18	1061..1082
		Interaction with NHERF1. /evidence=ECO:0000269|PubMed:21804599	1076..1205
		leucine-rich repeat	1107..1129	CDD:275380
		PP2Cc	1168..1420	CDD:214625
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1458..1510
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1673..1717
		PDZ-binding, required for interaction with NHERF1. /evidence=ECO:0000269|PubMed:21804599	1715..1717