DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbp and Trf2

DIOPT Version :9

Sequence 1:	NP_523805.1	Gene:	Tbp / 37476	FlyBaseID:	FBgn0003687	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	NP_001096905.1	Gene:	Trf2 / 31773	FlyBaseID:	FBgn0261793	Length:	1715	Species:	Drosophila melanogaster

Alignment Length:	317	Identity:	94/317 - (29%)
Similarity:	155/317 - (48%)	Gaps:	57/317 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DSLMPAPGSSSVQHQQQQQQSD----ASGGSGLFGHEPSLPLAHKQMQSYQPSASYQQQQQQQQL 102
            |:::.|.||.::.....:.:::    ||.|:||...:..| |..:.|||. .......:::::..
  Fly  1195 DTIVLATGSKNMFLTSSENKANLPTVASNGNGLITAKMDL-LEEEVMQSI-TVIDDDDEEKKEVA 1257

  Fly   103 QSQAPGGGGSTPQSMMQPQTPQSMMAHMMPMSERSVGGSGAGGGGDALSNIHQTMGPSTPMTPAT 167
            :.:......:.|..:.||                            ...|.|:.
  Fly  1258 EDEEESSNNAKPIDLHQP----------------------------IADNEHEL----------- 1283

  Fly   168 PGSADPGIVPQLQNIVSTVNLCCKLDLKKIALHARNAEYNPKRFAAVIMRIREPRTTALIFSSGK 232
                  .||  :.|:|.:.::.|.|.|::|||...|.||. :....|.|::|.|.|||.|:|||:
  Fly  1284 ------DIV--INNVVCSFSVGCHLKLREIALQGSNVEYR-RENGMVTMKLRHPYTTASIWSSGR 1339

  Fly   233 MVCTGAKSEDDSRLAARKYARIIQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHCNFSSY 297
            :.||||.||..:::|||:|||.:.|||||.:||:|:|.|::|:|.:.:.|::......|...:||
  Fly  1340 ITCTGATSESMAKVAARRYARCLGKLGFPTRFLNFRIVNVLGTCSMPWAIKIVNFSERHRENASY 1404

  Fly   298 EPELFPGLIYRM--VRPRIVLLIFVSGKVVLTGAKVRQEIYDAFDKIFPILKKFKKQ 352
            ||||.||:.|:|  ..|:..|.||.:|.|.:|.|.| ..:..|...|:|::..|:||
  Fly  1405 EPELHPGVTYKMRDPDPKATLKIFSTGSVTVTAASV-NHVESAIQHIYPLVFDFRKQ 1460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbp	NP_523805.1	PLN00062	176..351	CDD:177693	72/176 (41%)
Tbp	NP_523805.1	TBP_eukaryotes	176..349	CDD:239952	71/174 (41%)
Trf2	NP_001096905.1	GBP_C	<967..1068	CDD:303769
		coiled coil	1037..1048	CDD:293879
		coiled coil	1057..1068	CDD:293879
		TLF	1283..1456	CDD:239953	72/193 (37%)
		PLN00062	1285..1459	CDD:177693	73/177 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452071
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2101
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1219067at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10126
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850