DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbp and tbp-1

DIOPT Version :9

Sequence 1:	NP_523805.1	Gene:	Tbp / 37476	FlyBaseID:	FBgn0003687	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	NP_001370645.1	Gene:	tbp-1 / 176054	WormBaseID:	WBGene00006542	Length:	340	Species:	Caenorhabditis elegans

Alignment Length:	351	Identity:	181/351 - (51%)
Similarity:	216/351 - (61%)	Gaps:	61/351 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PAVSQPDSLMPAPGSSSVQHQQQQQQSDASGGSGLFGHEPSLPLAHKQM---------QSYQPSA 91
            ||...|:|::...|.||:                |.||.|:..:....:         ||.||..
Worm    16 PAHGGPNSVLGGQGPSSI----------------LTGHGPNSVMGPNSILGPGSVLNPQSIQPMQ 64

  Fly    92 SYQQ---QQQQQQLQSQAPGGG---GSTPQSMMQPQTPQSMMAHMMPMSERSVGGSGAGGGGDAL 150
            |.|.   |....|:.|......   ...|.|:...:.|.|:|.|.:.::..||          |.
Worm    65 SQQMHSLQGSSMQMHSHLANSNLNLNINPASVGPDRNPGSVMHHNLDINPPSV----------AY 119

  Fly   151 SNIHQTMGP--------------------STPMTPATPGSADPGIVPQLQNIVSTVNLCCKLDLK 195
            .|:...|.|                    :..|.||||.|.....:|.||||||||||..:||||
Worm   120 QNLTVPMTPLAYSVYDRDALTHQAPASNIAATMVPATPASQLDIPMPALQNIVSTVNLGVQLDLK 184

  Fly   196 KIALHARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEDDSRLAARKYARIIQKLGF 260
            ||||||||||||||||||||||||||||||||||||||||||||||:.|||||||||||:|||||
Worm   185 KIALHARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEASRLAARKYARIVQKLGF 249

  Fly   261 PAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHCNFSSYEPELFPGLIYRMVRPRIVLLIFVSGKVV 325
            .|||.:|.:|||||||||:|||:||||.:||..||:||||||||||||||:||:|||||||||||
Worm   250 QAKFTEFMVQNMVGSCDVRFPIQLEGLCITHSQFSTYEPELFPGLIYRMVKPRVVLLIFVSGKVV 314

  Fly   326 LTGAKVRQEIYDAFDKIFPILKKFKK 351
            :||||.:::|.:||.:|:||||.|||
Worm   315 ITGAKTKRDIDEAFGQIYPILKGFKK 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbp	NP_523805.1	PLN00062	176..351	CDD:177693	141/174 (81%)
Tbp	NP_523805.1	TBP_eukaryotes	176..349	CDD:239952	140/172 (81%)
tbp-1	NP_001370645.1	TBP_eukaryotes	165..338	CDD:239952	140/172 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156684
Domainoid	1	1.000	142	1.000	Domainoid score	I2919
eggNOG	1	0.900	-	-		E1_COG2101
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	307	1.000	Inparanoid score	I1582
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1219067at2759
OrthoFinder	1	1.000	-	-		FOG0001202
OrthoInspector	1	1.000	-	-		oto20289
orthoMCL	1	0.900	-	-		OOG6_100597
Panther	1	1.100	-	-	LDO	PTHR10126
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1482
SonicParanoid	1	1.000	-	-		X1201
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.830