Protein Alignment KCNC2 and Shab

DIOPT Version :9

• Sequence 1: NP_631875.1
• Gene: KCNC2 / 3747
• HGNCID: 6234
• Length: 638
• Species: Homo sapiens
• Sequence 2: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Alignment Length: 646
• Identity: 208/646 - (32%)
• Similarity: 306/646 - (47%)
• Gaps: 124/646 - (19%)

Human     7 NERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPRAPPLS 71
            |.||.:||||.|||....||:.||.|||..|.      :|.|
  Fly   306 NSRVSINVGGVRHEVLWRTLERLPHTRLGRLR------ECTT----------------------- 341

Human    72 PGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEE 136
                  .|.....|       .|:.....|:||||||..|:.:||:|||||||...::|...|.:
  Fly   342 ------HEAIVELC-------DDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSD 393

Human   137 ELAFWGIDETDVEPCCWMTYRQHRD------AEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDA 195
            :|.:||:||..:|.||...|.|.::      .:||..:.:.         |:|:..
  Fly   394 DLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESLRQR---------DEEEFG--------- 440

Human   196 AGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNK 260
                  :||...:   |..:|.|.|.|.:|.|||.||..|:.||::|.....|.|       ..:
  Fly   441 ------EGKCAEY---QKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNT-------LPQ 489

Human   261 TEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILP 325
            .:.:.|||.       :.:|.|..||.||:.|||.|:::|...||:|.:|.|..|||||.:||||
  Fly   490 LQHIDNGTP-------QDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILP 547

Human   326 FYLEVGLSGLSSKAA---KDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLII 387
            :::.:.|...:..|.   :||...::|.|.:|||||.||.||..||:.||.|||.|..|..||::
  Fly   548 YFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLML 612

Human   388 FLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGML 452
            |||:|||||:::.|:||:         ..:.|:|.:||..||||.:||||:||||:||.|..|.:
  Fly   613 FLAMGVLIFSSLAYFAEK---------DEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKV 668

Human   453 VGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMAC 517
            :|.:|.:.|||.||:|:|:|||||..:|...|.::|..::|:.......:.|..:|....|..|.
  Fly   669 IGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLKDAF 733

Human   518 NSTQS------DTCLGKDNRLLEHNRSVLSGDDSTGSEP---PLSPPERLPIRRSSTRDKNRRGE 573
            ..:..      ||  ||...:: |.:.......:.|.:.   ..:|...|    |.|...:..||
  Fly   734 AKSMDLIDVIVDT--GKQTNVV-HPKGKRQSTPNIGRQTLDVQSAPGHNL----SQTDGNSTEGE 791

Human   574 TCFLLTTGDYTCASDGGIRKGYEKSRSL--NNIAGLAGNALRLSPVTSPYNSPCPLRRSRS 632
            :    |:|.....:..|..|.|:...:|  :|:....|::.....| .||:...|..|..|
  Fly   792 S----TSGRNPATTGTGCYKNYDHVANLRNSNLHNRRGSSSEQDAV-PPYSFDNPNARQTS 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNC2	NP_631875.1	BTB_KCNC2_4	7..166	CDD:349722	53/164 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	38..93		4/54 (7%)
		Ion_trans	228..484	CDD:395416	110/258 (43%)
		Selectivity filter. /evidence=ECO:0000250	437..442		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	538..572		5/36 (14%)
Shab	NP_001189037.1	BTB	309..416	CDD:197585	49/148 (33%)
		BTB_2	309..408	CDD:280393	46/140 (33%)
		Ion_trans	501..700	CDD:278921	97/207 (47%)
		Ion_trans_2	613..696	CDD:285168	45/91 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820