DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rae1 and RAE1

DIOPT Version :9

Sequence 1:	NP_611597.1	Gene:	Rae1 / 37467	FlyBaseID:	FBgn0034646	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	XP_005260640.1	Gene:	RAE1 / 8480	HGNCID:	9828	Length:	406	Species:	Homo sapiens

Alignment Length:	349	Identity:	240/349 - (68%)
Similarity:	280/349 - (80%)	Gaps:	5/349 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFGA--TQSTNRMNDFEVASPPDDSVSALEFSPSTVQKNFLVAGSWDSTVRCWEVEQNGATVPKS 63
            |||:  |.:.|.|.|.||.|.||||:..|.|||.|:..|||:||||.:.||||||:.:|.|:||:
Human    55 MFGSATTDNHNPMKDIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKA 119

  Fly    64 MKTMGGPVLDVCWSDDGSKVFVASCDKQVKLWDLASDQVMQVAAHDGPVKTCHMVKGPTYTCLMT 128
            .:...||||||||||||||||.|||||..|:|||:|:|.:|:|.||.||||.|.:|.|.|:|:||
Human   120 QQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMT 184

  Fly   129 GSWDKTLKFWDTRSPNPMMTINLPERCYCADVEYPMAVVGTANRGLIIYSLQNSPTEYKRQESPL 193
            ||||||||||||||.||||.:.||||||||||.||||||.||.||||:|.|:|.|:|::|.||||
Human   185 GSWDKTLKFWDTRSSNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPL 249

  Fly   194 KYQHRAISIFRDKKKEPTGCALGSIEGRVAIQYVNPGNP-KDNFTFKCHRTTG--TSGYQDIYAV 255
            |:|||.::||:||:.:|||.|||||||||||.|:||.|| ||||||||||:.|  ||..||||||
Human   250 KHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAV 314

  Fly   256 NDIAFHPVHGTLVTVGSDGTFSFWDKDARTKLKSSETMDQSITKCGFNANGQIFAYAVGYDWSKG 320
            |.||||||||||.||||||.|||||||||||||:||.:||.|:.|.||.||.|||||..||||||
Human   315 NGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASSYDWSKG 379

  Fly   321 HEYFNPAKKPQIFLRSCYDELKPR 344
            ||::||.||..||||:..:|||||
Human   380 HEFYNPQKKNYIFLRNAAEELKPR 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rae1	NP_611597.1	WD40	22..310	CDD:421866	203/290 (70%)
		WD40 repeat	25..66	CDD:293791	22/40 (55%)
		WD40 repeat	71..105	CDD:293791	25/33 (76%)
		WD40 repeat	113..150	CDD:293791	27/36 (75%)
		WD40 repeat	157..239	CDD:293791	58/82 (71%)
		WD40 repeat	255..293	CDD:293791	33/37 (89%)
RAE1	XP_005260640.1	WD40	77..>375	CDD:225201	208/297 (70%)
		WD40	78..373	CDD:295369	207/294 (70%)
		WD40 repeat	80..122	CDD:293791	22/41 (54%)
		WD40 repeat	128..163	CDD:293791	25/34 (74%)
		WD40 repeat	168..206	CDD:293791	28/37 (76%)
		WD40 repeat	212..246	CDD:293791	23/33 (70%)
		WD40 repeat	253..296	CDD:293791	30/42 (71%)
		WD40 repeat	314..364	CDD:293791	39/49 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146370
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0647
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2676
Inparanoid	1	1.050	514	1.000	Inparanoid score	I1310
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53489
OrthoDB	1	1.010	-	-		D1048963at2759
OrthoFinder	1	1.000	-	-		FOG0003056
OrthoInspector	1	1.000	-	-		oto89314
orthoMCL	1	0.900	-	-		OOG6_101883
Panther	1	1.100	-	-	LDO	PTHR10971
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1067
SonicParanoid	1	1.000	-	-		X2897
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800