DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rae1 and Rae1

DIOPT Version :9

Sequence 1:	NP_611597.1	Gene:	Rae1 / 37467	FlyBaseID:	FBgn0034646	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_780321.1	Gene:	Rae1 / 66679	MGIID:	1913929	Length:	368	Species:	Mus musculus

Alignment Length:	349	Identity:	240/349 - (68%)
Similarity:	278/349 - (79%)	Gaps:	5/349 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFGATQSTNR--MNDFEVASPPDDSVSALEFSPSTVQKNFLVAGSWDSTVRCWEVEQNGATVPKS 63
            |||:|.:.|.  |.|.||.|.||||:..|.|||.|:..|||:||||.:.||||||:.:|.|:||:
Mouse    17 MFGSTTTDNHNPMKDIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKA 81

  Fly    64 MKTMGGPVLDVCWSDDGSKVFVASCDKQVKLWDLASDQVMQVAAHDGPVKTCHMVKGPTYTCLMT 128
            .:...||||||||||||||||.|||||..|:|||.|:|.:|:|.||.||||.|.:|.|.|:|:||
Mouse    82 QQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLNSNQAIQIAQHDAPVKTIHWIKAPNYSCVMT 146

  Fly   129 GSWDKTLKFWDTRSPNPMMTINLPERCYCADVEYPMAVVGTANRGLIIYSLQNSPTEYKRQESPL 193
            ||||||||||||||.||||.:.||||||||||.||||||.||.||||:|.|:|.|:|::|.||||
Mouse   147 GSWDKTLKFWDTRSSNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPL 211

  Fly   194 KYQHRAISIFRDKKKEPTGCALGSIEGRVAIQYVNPGNP-KDNFTFKCHRTTG--TSGYQDIYAV 255
            |:|||.::||:||:.:|||.|||||||||||.|:||.|| ||||||||||:.|  ||..||||||
Mouse   212 KHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAV 276

  Fly   256 NDIAFHPVHGTLVTVGSDGTFSFWDKDARTKLKSSETMDQSITKCGFNANGQIFAYAVGYDWSKG 320
            |.||||||||||.||||||.|||||||||||||:||.:||.|..|.||.||.|||||..||||||
Mouse   277 NGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPIAACCFNHNGNIFAYASSYDWSKG 341

  Fly   321 HEYFNPAKKPQIFLRSCYDELKPR 344
            ||::||.||..||||:..:|||||
Mouse   342 HEFYNPQKKNYIFLRNAAEELKPR 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rae1	NP_611597.1	WD40	22..310	CDD:421866	203/290 (70%)
		WD40 repeat	25..66	CDD:293791	22/40 (55%)
		WD40 repeat	71..105	CDD:293791	25/33 (76%)
		WD40 repeat	113..150	CDD:293791	27/36 (75%)
		WD40 repeat	157..239	CDD:293791	58/82 (71%)
		WD40 repeat	255..293	CDD:293791	33/37 (89%)
Rae1	NP_780321.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..34		9/18 (50%)
		WD 1	37..79		24/41 (59%)
		WD40	40..335	CDD:421866	208/297 (70%)
		WD40 repeat	42..84	CDD:293791	22/41 (54%)
		WD 2	84..114		24/29 (83%)
		WD40 repeat	90..125	CDD:293791	24/34 (71%)
		WD 3	125..157		23/31 (74%)
		WD40 repeat	130..168	CDD:293791	26/37 (70%)
		WD 4	168..206		27/37 (73%)
		WD40 repeat	174..208	CDD:293791	22/33 (67%)
		WD40 repeat	215..258	CDD:293791	31/43 (72%)
		WD 5	215..255		28/40 (70%)
		WD 6	271..301		26/29 (90%)
		WD40 repeat	276..326	CDD:293791	38/49 (78%)
		WD 7	310..346		24/35 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836452
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0647
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2676
Inparanoid	1	1.050	514	1.000	Inparanoid score	I1291
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53489
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003056
OrthoInspector	1	1.000	-	-		oto92884
orthoMCL	1	0.900	-	-		OOG6_101883
Panther	1	1.100	-	-	LDO	PTHR10971
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1067
SonicParanoid	1	1.000	-	-		X2897
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.790