DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rae1 and rae1

DIOPT Version :9

Sequence 1:	NP_611597.1	Gene:	Rae1 / 37467	FlyBaseID:	FBgn0034646	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_001017142.1	Gene:	rae1 / 549896	XenbaseID:	XB-GENE-995595	Length:	368	Species:	Xenopus tropicalis

Alignment Length:	349	Identity:	240/349 - (68%)
Similarity:	283/349 - (81%)	Gaps:	5/349 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFG--ATQSTNRMNDFEVASPPDDSVSALEFSPSTVQKNFLVAGSWDSTVRCWEVEQNGATVPKS 63
            |||  ||.:.|.|.|.||.||||||:|.|.|||.|:..|||:||||.:.||||||:.||.|:||:
Frog    17 MFGSTATDNHNPMKDIEVTSPPDDSISCLSFSPPTLPGNFLIAGSWANDVRCWEVQDNGQTIPKA 81

  Fly    64 MKTMGGPVLDVCWSDDGSKVFVASCDKQVKLWDLASDQVMQVAAHDGPVKTCHMVKGPTYTCLMT 128
            .:...||||||||||||||||.|||||..|:|||.|:|.:|:|.||.|:||.|.||.|.|:|:||
Frog    82 QQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLNSNQSIQIAQHDAPIKTVHWVKAPNYSCIMT 146

  Fly   129 GSWDKTLKFWDTRSPNPMMTINLPERCYCADVEYPMAVVGTANRGLIIYSLQNSPTEYKRQESPL 193
            |||||:|||||||||||::|:.||||||||||.||||||.||.||||:|.|:|.|:|::|.:|||
Frog   147 GSWDKSLKFWDTRSPNPLLTLQLPERCYCADVVYPMAVVATAERGLIVYQLENQPSEFRRIDSPL 211

  Fly   194 KYQHRAISIFRDKKKEPTGCALGSIEGRVAIQYVNPGNP-KDNFTFKCHRTTG--TSGYQDIYAV 255
            |:|||.::||:||:.:|||.|||||||||||.|:||.|| ||||||||||:.|  |:..||||||
Frog   212 KHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTTAPQDIYAV 276

  Fly   256 NDIAFHPVHGTLVTVGSDGTFSFWDKDARTKLKSSETMDQSITKCGFNANGQIFAYAVGYDWSKG 320
            |.||||||||||.||||||.|||||||||||||:||.:||.|:.|.||.||.||||:..||||||
Frog   277 NGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACSFNHNGNIFAYSSSYDWSKG 341

  Fly   321 HEYFNPAKKPQIFLRSCYDELKPR 344
            ||::||.||..||||:..:|||||
Frog   342 HEFYNPQKKNYIFLRNAAEELKPR 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rae1	NP_611597.1	WD40	22..310	CDD:421866	202/290 (70%)
		WD40 repeat	25..66	CDD:293791	24/40 (60%)
		WD40 repeat	71..105	CDD:293791	25/33 (76%)
		WD40 repeat	113..150	CDD:293791	27/36 (75%)
		WD40 repeat	157..239	CDD:293791	57/82 (70%)
		WD40 repeat	255..293	CDD:293791	33/37 (89%)
rae1	NP_001017142.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37		10/19 (53%)
		WD 1	37..79		27/41 (66%)
		WD40	40..337	CDD:421866	205/296 (69%)
		WD40 repeat	42..84	CDD:293791	24/41 (59%)
		WD 2	84..114		22/29 (76%)
		WD40 repeat	90..125	CDD:293791	25/34 (74%)
		WD 3	125..157		21/31 (68%)
		WD40 repeat	130..168	CDD:293791	27/37 (73%)
		WD 4	168..206		27/37 (73%)
		WD40 repeat	174..208	CDD:293791	23/33 (70%)
		WD40 repeat	215..258	CDD:293791	30/42 (71%)
		WD 5	215..255		27/39 (69%)
		WD 6	271..301		26/29 (90%)
		WD40 repeat	276..326	CDD:293791	39/49 (80%)
		WD 7	310..346		22/35 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2676
Inparanoid	1	1.050	520	1.000	Inparanoid score	I1247
OMA	1	1.010	-	-		QHG53489
OrthoDB	1	1.010	-	-		D1048963at2759
OrthoFinder	1	1.000	-	-		FOG0003056
OrthoInspector	1	1.000	-	-		oto103151
Panther	1	1.100	-	-	LDO	PTHR10971
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1067
SonicParanoid	1	1.000	-	-		X2897
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110