DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rae1 and CG12782

DIOPT Version :9

Sequence 1:	NP_611597.1	Gene:	Rae1 / 37467	FlyBaseID:	FBgn0034646	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_611772.2	Gene:	CG12782 / 37685	FlyBaseID:	FBgn0034838	Length:	336	Species:	Drosophila melanogaster

Alignment Length:	334	Identity:	140/334 - (41%)
Similarity:	201/334 - (60%)	Gaps:	9/334 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FGATQSTNRMNDFEVASPPDDSVSALEFSPSTVQKNFLVAGSWDSTVRCWEVEQNGATVPKSMKT 66
            ||..:.| :..|:|:.:||:|::|||||||.:...|.:.|||||:|||.||| |....|||.|.:
  Fly     4 FGQPKQT-QQQDYELPNPPNDTISALEFSPRSSSWNAICAGSWDNTVRIWEV-QADRLVPKVMNS 66

  Fly    67 MGGPVLDVCWSDDGSKVFVASCDKQVKLWDLASDQVMQVAAHDGPVKTCHMVKGPTYTCLMTGSW 131
            :.|...||.|:|.|:||:::....||..|||.|:|:.:|..|....:|||.| ||   .|.|.||
  Fly    67 LEGTPFDVTWNDSGNKVYLSDSSGQVTEWDLESNQLRKVGLHARAARTCHWV-GP---YLATTSW 127

  Fly   132 DKTLKFWDTRSPNPMMTINLPERCYCADVEYPMAVVGTANRGLIIYSLQNSPTEYKRQESPLKYQ 196
            ||:::|||.|:...:..:.||:|.|.|||...:|||...:|.::.|:|:..|.|..|.:||.:..
  Fly   128 DKSIRFWDPRAAIELTRMELPDRSYAADVLNDVAVVACGDRSILAYTLRGGPVEQGRMKSPGESN 192

  Fly   197 HRAISIFRDKKKEPTGCALGSIEGRVAIQYVNPGNPKDNFTFKCHRTTGTSGYQDIYAVNDIAFH 261
            .:..|:...:.::.|...:....|.|..|  :..:...:|..:|||.. .||..|:||||::..:
  Fly   193 TQVRSVALHQNRDLTSWLIAKTNGMVFDQ--SMAHRTVSFPIRCHRRE-NSGILDVYAVNEVKVN 254

  Fly   262 PVHGTLVTVGSDGTFSFWDKDARTKLKSSETMDQSITKCGFNANGQIFAYAVGYDWSKGHEYFNP 326
            .|...:.||||||.|.|||...|:||..|:...|.||||..:.:|::||||:||||||||||.:.
  Fly   255 MVTQHIATVGSDGVFCFWDSQMRSKLLESKVHPQPITKCAISGDGKLFAYALGYDWSKGHEYSDS 319

  Fly   327 AKKPQIFLR 335
            :.||.||||
  Fly   320 SIKPHIFLR 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rae1	NP_611597.1	WD40	22..310	CDD:421866	113/287 (39%)
		WD40 repeat	25..66	CDD:293791	24/40 (60%)
		WD40 repeat	71..105	CDD:293791	14/33 (42%)
		WD40 repeat	113..150	CDD:293791	16/36 (44%)
		WD40 repeat	157..239	CDD:293791	20/81 (25%)
		WD40 repeat	255..293	CDD:293791	17/37 (46%)
CG12782	NP_611772.2	WD40	<19..303	CDD:225201	115/291 (40%)
		WD40	25..303	CDD:295369	112/285 (39%)
		WD40 repeat	26..64	CDD:293791	23/38 (61%)
		WD40 repeat	71..101	CDD:293791	13/29 (45%)
		WD40 repeat	109..146	CDD:293791	16/40 (40%)
		WD40 repeat	195..235	CDD:293791	6/41 (15%)
		WD40 repeat	242..272	CDD:293791	13/29 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447782
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0647
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1048963at2759
OrthoFinder	1	1.000	-	-		FOG0003056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10971
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850