DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF7 and klp3

DIOPT Version :9

Sequence 1:	XP_011519833.1	Gene:	KIF7 / 374654	HGNCID:	30497	Length:	1384	Species:	Homo sapiens
Sequence 2:	NP_594686.1	Gene:	klp3 / 2542195	PomBaseID:	SPAC1834.07	Length:	554	Species:	Schizosaccharomyces pombe

Alignment Length:	526	Identity:	160/526 - (30%)
Similarity:	246/526 - (46%)	Gaps:	86/526 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    57 VRVALRVRPLLPKELLHG--------HQSCLQVEPGLGRVTLGRDRHFGFHVVLAEDAGQEAVYQ 113
            ::|..|:||....|...|        :.|.:.:|      |.....:|.|..|....:.|..::.
pombe     4 IKVVCRIRPTNQLEQDLGGNNVIYPLNDSTVHIE------TSDYSGNFVFDRVFHPSSTQNDIFS 62

Human   114 ACVQPLLEAFFEGFNATVFAYGQTGSGKTYTMGEASVASLLEDEQGIVPRAMAEAF-KLIDENDL 177
            ..::..::..|.|:|.||.|||||||||||||  ..:.:..|.| |:.||.:...| |:.|....
pombe    63 YSIESTVDDLFLGYNGTVLAYGQTGSGKTYTM--MGIENNFEKE-GMTPRMLRRIFDKIRDSPST 124

Human   178 LDCLVHVSYLEVYKEEFRDLLEVGTASRD-IQLREDERGNVVLCGVKEVDVEGLDEVLSLLEMGN 241
            .:..|.|||:|:|.|:..|||   :...| :.:.||:...|.:.|:|.:.|....|.|.:|..|.
pombe   125 TEYEVKVSYMEIYMEKIHDLL---SEKNDRLTVHEDKLQGVYVQGLKTIYVSSETEALDILNKGM 186

Human   242 AARHTGATHLNHLSSRSHTVFTVTLEQRGRAPSRLPRPAPGQLLVSKFHFVDLAGSERVLKTGST 306
            .:|...:|.:|..|||||::|.:.:.|.........|   |:|.:     |||||||.|.|:|:.
pombe   187 GSRAVASTSMNAQSSRSHSIFVLEVVQTDTESGETRR---GRLFL-----VDLAGSESVGKSGAV 243

Human   307 GERLKESIQINSSLLALGNVISALGDPQRRGSHIPYRDSKITRILKDSLGGNAKTVMIACVSPSS 371
            |:.|:|:.:||.||..||.||::|.|.:.  ||:||||||:|||||:|||||::|.:|...||.|
pombe   244 GQTLEEAKKINRSLSTLGMVINSLTDSKL--SHVPYRDSKLTRILKESLGGNSRTTLIINCSPDS 306

Human   372 SDFDETLNTLNYASRAQNIRNRATVNWRPEAERPPEETASGARGPPRHRSETRIIHRGRRAPGPA 436
            .:..|||:||.:..||::|:|:|.||    :|...:|.             .|.::..:.|....
pombe   307 YNATETLSTLRFGHRAKSIKNKAVVN----SELSVDEM-------------KRQLYIYKDALSRC 354

Human   437 TASAAAAMRLGAECARYRACTDAAYS-----LLRELQAEPGLPGAAARKVRDWLCAVEGERSALS 496
            ...|.....|.     |..|....:|     .|..|..:..|..|.         .::|.|:...
pombe   355 VCGARINNNLD-----YNNCHSNVWSGEHSLTLSNLAEKSNLKEAE---------IIQGNRTIQE 405

Human   497 SASGPDS---------GIESASVEDQAAQGAGGRKEDEGAQQLLTLQNQVARLEEENRDFLAALE 552
            |.:..|.         ..:|.|:....|:.....|:.:|.         ::..:::..|.:.||.
pombe   406 SNNDRDESTVASIHRHNFDSDSINRLYAEAQLELKQRDGV---------LSSTKQQLSDLMTALG 461

Human   553 DAMEQY 558
            ||.|:|
pombe   462 DAQERY 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF7	XP_011519833.1	KISc	56..397	CDD:214526	129/349 (37%)
		KISc_KIF4	56..391	CDD:276823	126/343 (37%)
		TPP_enzymes	<541..615	CDD:294952	7/18 (39%)
		FAM184	774..993	CDD:292293
		Utp11	891..1069	CDD:295201
klp3	NP_594686.1	KIP1	1..546	CDD:227392	160/526 (30%)
klp3	NP_594686.1	KISc_KHC_KIF5	1..325	CDD:276820	126/342 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910