DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10321 and AZF1

DIOPT Version :9

Sequence 1:	NP_001261124.1	Gene:	CG10321 / 37464	FlyBaseID:	FBgn0034643	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_014756.3	Gene:	AZF1 / 854280	SGDID:	S000005639	Length:	914	Species:	Saccharomyces cerevisiae

Alignment Length:	861	Identity:	166/861 - (19%)
Similarity:	286/861 - (33%)	Gaps:	245/861 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 QQRQLQKQQKILEEQLQQQIVQQQQHQPPAK-PKLKPLLRKGSRQQKQ---RHLEAAPAP---QS 169
            ||:|||.|.:    |.|||..||...|||.| |.....| .||..|.|   |:...:..|   .|
Yeast   136 QQQQLQNQHR----QQQQQQQQQSHQQPPFKTPSFSTGL-TGSSSQYQFLPRNDNTSQPPSKRNS 195

  Fly   170 V---PQPAPQPQ-MQLMQEHAPQ-QPTMQQQIQQIHMPTLQPAPAQLLSAAGATTTMPQQILLPN 229
            |   |...|..: ..:.|...|| ||:.:::...:..|.|.||         |||.........:
Yeast   196 VYLGPNDGPDFEFFSMQQSQQPQFQPSSRRESNSMRPPLLIPA---------ATTKSQSNGTNNS 251

  Fly   230 GQLITTAQIVAPQLAQIISTAPQSTTNGQATAAQSQFLPQLLQTPNGQTLQIVQQ--------PN 286
            |.:.|.|     ......:|...::.:.|.....|.....|...|.....|..::        .:
Yeast   252 GNMNTNA-----DYESFFNTGTNNSNSNQNPYFLSSRNNSLKFNPEDFDFQFKRRNSFVRGTLDH 311

  Fly   287 GTQTLQLVQLVPQRSLAPTGVTTVTTTTNATDMGQHVGASL-GDADVQLLEDGCEVEDEELEDVY 350
            .:|.    ..:|:..|   ...:|....|...:..:|..:: |.::        ||::::..|..
Yeast   312 SSQN----AFIPESRL---NSLSVNNKANGDPVADNVTNNMKGKSN--------EVDNDDGNDSS 361

  Fly   351 EQLDSKADHSFETIVLDDDQQQDFLKDHHEHHQVMINEDLTQS--ESQDHEYFDDLDQQQAMDEI 413
            ...::..:::      :::...|...|::::   .||...:.:  ..:||..........:..::
Yeast   362 NNNNNNNNNN------NNENNNDNNNDNNDN---SINSATSTNIPNQEDHSLASTDTTSNSRKDL 417

  Fly   414 EDEEEQMKP---EEDQDTFIIEEIQLEDDEMLDDPDG-----------------EEIDQDCEYIG 458
            ::.|::::.   :||..:..|.. .|:.:::::..:|                 .:.|....|:.
Yeast   418 KEIEQRLRKHLNDEDNYSSAISR-PLDKNDVIEGSEGLNKHIDESGMQPNIIKKRKKDDSTVYVK 481

  Fly   459 EEQ---DPHLSGDVDDDLE------YSIMEPPDGETSVDIDQAFMDSEQSHHQQHQEEMQSISLE 514
            .|.   ||.:|.|.....|      :|..|||    ..||.....|:.........:::..| ::
Yeast   482 NEMPRTDPPMSKDNSTSAEGAAMANFSGKEPP----IPDISSVSDDATNLIGATKVDQLMLI-IQ 541

  Fly   515 NAVVEFSQATTTT---EALVGPTMTVSSASPTPKRAKRSNHQIPAGVTLEPCDHQPPAAGSTTSS 576
            .....|::...||   :.|...||.:.    .||      .::..||      .:|....:|.:.
Yeast   542 ARKKGFTEKVNTTQDGDLLFNQTMDIL----PPK------SELVGGV------EKPKGTQNTRAV 590

  Fly   577 KLAAANSRQLVQTASVIAAAGADDNYEIDANLVTEFIRQHTSPLGSGRYICHLCSTEFRQFKGLQ 641
            |                                              ::.|..|...|.|...|:
Yeast   591 K----------------------------------------------KHECPYCHRLFSQATHLE 609

  Fly   642 NHMHSHTNWIRANCKKQPQCQICLKSFKGPGMLRMHMKTHDAESSTPMCTICNRTFKSKAILYRH 706
            .|:.||..:      |...|..|.|.|...|.||.|.:.|..|... .|.||::.|..|..|..|
Yeast   610 VHVRSHIGY------KPFVCDYCGKRFTQGGNLRTHERLHTGEKPY-SCDICDKKFSRKGNLAAH 667

  Fly   707 RQTHQQ-RAYCCGVANCRKNFSSAVNLKWHVERKHPEVVDPL-FKCGEC---------------- 753
            ..|||: :.:.|.:.||.|.|:...|:|.|..|.|.|.::.| .|..|.
Yeast   668 LVTHQKLKPFVCKLENCNKTFTQLGNMKAHQNRFHKETLNALTAKLAEMNPSENIPLEERQLLEY 732

  Fly   754 -GSLYDN------------------VDSLQLHVEST------------------DHSAEVQISGQ 781
             .|:|.|                  :.|.:.|..||                  :.:.|..|...
Yeast   733 FASIYKNSNRGIKGRGKGVGTKKSTISSPENHPASTILNPNTNANNAIANDSENNGNPEGNIDSS 797

  Fly   782 DDAFSGAVSIVSNGTTDM----SNMMATGQGTTLAGGTGDTHAVV-----------MGSSGEVYF 831
            .::..|:.|::|....||    |..:......::.........::           :|||....
Yeast   798 SNSNPGSHSMISPTQKDMGTLQSQFIQNNFNNSVNSSNPSNQPIINYNYTTLPHSRLGSSSSSN- 861

  Fly   832 VTQAXPAEFAAAGAPG 847
             |....:.|:...|||
Yeast   862 -TNNNNSNFSVGAAPG 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10321	NP_001261124.1	zf-AD	12..80	CDD:214871
		ASF1_hist_chap	<405..516	CDD:304562	22/139 (16%)
		C2H2 Zn finger	627..647	CDD:275368	6/19 (32%)
		C2H2 Zn finger	661..681	CDD:275368	8/19 (42%)
		C2H2 Zn finger	690..710	CDD:275368	7/19 (37%)
		C2H2 Zn finger	717..740	CDD:275368	9/22 (41%)
		C2H2 Zn finger	750..767	CDD:275368	5/51 (10%)
AZF1	NP_014756.3	COG5048	342..768	CDD:227381	93/517 (18%)
		C2H2 Zn finger	595..615	CDD:275368	6/19 (32%)
		C2H2 Zn finger	623..643	CDD:275368	8/19 (42%)
		C2H2 Zn finger	651..671	CDD:275368	7/19 (37%)
		C2H2 Zn finger	679..702	CDD:275368	9/22 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000