DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10321 and ZBTB17

DIOPT Version :9

Sequence 1:NP_001261124.1 Gene:CG10321 / 37464 FlyBaseID:FBgn0034643 Length:855 Species:Drosophila melanogaster
Sequence 2:NP_001274532.1 Gene:ZBTB17 / 7709 HGNCID:12936 Length:810 Species:Homo sapiens


Alignment Length:693 Identity:150/693 - (21%)
Similarity:232/693 - (33%) Gaps:179/693 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   276 GQTLQIVQQPNGTQTLQLVQLVPQRSLAPTGVTTVTTTTNATDMGQ-----HVGASL-------- 327
            ||.|:.:      .|.:|       ||:|..|..|........|..     |...||        
Human    71 GQVLEFM------YTAKL-------SLSPENVDDVLAVATFLQMQDIITACHALKSLAEPATSPG 122

  Fly   328 GDADVQLLEDGCEVEDEE---------LE------------DVYE----QLDSKADHSFETIVLD 367
            |:|:....|.|.:...||         ||            |:.|    |..|.|..:.:|...|
Human   123 GNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLKEERGGQAQSAASGAEQTEKAD 187

  Fly   368 DDQQQD--FLKDHHEHHQVMINEDLTQSESQDHEYFDDLD-----QQQAMDEIEDEEEQMKPEED 425
            ..::..  .||............:...|||.:.|.  :::     :::..::.|.|||...|.|.
Human   188 APREPPPVELKPDPTSGMAAAEAEAALSESSEQEM--EVEPARKGEEEQKEQEEQEEEGAGPAEV 250

  Fly   426 QDTFIIEEIQLEDDEMLDDPDGEE---IDQDCEYIGEEQDPHLSGDVDDDLEY----SIMEPPD- 482
            ::    |..|||:.|..::.:.||   .|...| :|.|.....||...|..|.    |::...: 
Human   251 KE----EGSQLENGEAPEENENEESAGTDSGQE-LGSEARGLRSGTYGDRTESKAYGSVIHKCED 310

  Fly   483 -------------------GE---TSVDIDQAFMDSE--QSHHQQHQ-----------EEMQSIS 512
                               ||   :..:..:||.|..  ::|.:.|.           :..:.||
Human   311 CGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAFSDPAACKAHEKTHSPLKPYGCEECGKSYRLIS 375

  Fly   513 LENAVVEFSQATTTTEAL-----VGPTMTVSSASPTPKRAKRSNHQ-IPAGVTLEPCDHQPPAAG 571
            |.|    ..:...:.||.     .|...|.|.      ..||  || :.:|.....||:    .|
Human   376 LLN----LHKKRHSGEARYRCEDCGKLFTTSG------NLKR--HQLVHSGEKPYQCDY----CG 424

  Fly   572 STTSSKLAAANSRQLVQTASVIAAAGADDNYEIDANLVTEFIRQHTSPLGSGRYICHLCSTEFRQ 636
            .:.|...:.....:...|.........|..:....||... ::.|   :..|...|..|..:|..
Human   425 RSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVGNLKAH-LKIH---IADGPLKCRECGKQFTT 485

  Fly   637 FKGLQNHMHSHTNWIRANCKKQPQCQICLKSFKGPGMLRMHMKTHDAESSTPMCTICNRTFKSKA 701
            ...|:.|:..|:.      :|...|..|.:.|..||.|:.|::.|..|... .|.:|.:.|...:
Human   486 SGNLKRHLRIHSG------EKPYVCIHCQRQFADPGALQRHVRIHTGEKPC-QCVMCGKAFTQAS 543

  Fly   702 ILYRH-RQTHQQRAYCCGVANCRKNFSSAVNLKWHVERKHPEV--------------VDPLFK-- 749
            .|..| ||...::.|.|  ..|.|.|..:..|..|: |.|..:              |..|.|  
Human   544 SLIAHVRQHTGEKPYVC--ERCGKRFVQSSQLANHI-RHHDNIRPHKCSVCSKAFVNVGDLSKHI 605

  Fly   750 ----------CGECGSLYDNVDSLQLHVESTDHSAEVQISGQDDAFSGAVSIVSNGTTDMSNMMA 804
                      |.:||..::.||:|:.||: |.|..:..|...:......||:|   |.|....:|
Human   606 IIHTGEKPYLCDKCGRGFNRVDNLRSHVK-TVHQGKAGIKILEPEEGSEVSVV---TVDDMVTLA 666

  Fly   805 T----GQGTTLAGGTGDTHAVVMGSSGEVYFVTQAXPAEFAAA 843
            |    ....|...|.....|||...:......|:. .||.:.|
Human   667 TEALAATAVTQLTGPATLPAVVPVGAAVTADETEVLKAEISKA 709

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10321NP_001261124.1 zf-AD 12..80 CDD:214871
ASF1_hist_chap <405..516 CDD:304562 32/158 (20%)
C2H2 Zn finger 627..647 CDD:275368 5/19 (26%)
C2H2 Zn finger 661..681 CDD:275368 7/19 (37%)
C2H2 Zn finger 690..710 CDD:275368 7/20 (35%)
C2H2 Zn finger 717..740 CDD:275368 7/22 (32%)
C2H2 Zn finger 750..767 CDD:275368 6/16 (38%)
ZBTB17NP_001274532.1 BTB 14..109 CDD:279045 11/50 (22%)
BTB 25..109 CDD:197585 11/50 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 116..295 40/185 (22%)
Interaction with MYC 269..308 11/39 (28%)
COG5048 306..637 CDD:227381 75/361 (21%)
zf-C2H2 306..328 CDD:278523 0/21 (0%)
C2H2 Zn finger 308..328 CDD:275368 0/19 (0%)
zf-H2C2_2 320..344 CDD:290200 3/23 (13%)
C2H2 Zn finger 336..356 CDD:275368 4/19 (21%)
C2H2 Zn finger 364..384 CDD:275368 4/23 (17%)
zf-C2H2 390..412 CDD:278523 7/29 (24%)
C2H2 Zn finger 392..412 CDD:275368 7/27 (26%)
zf-H2C2_2 404..428 CDD:290200 8/29 (28%)
C2H2 Zn finger 420..440 CDD:275368 4/23 (17%)
zf-C2H2 446..468 CDD:278523 3/22 (14%)
C2H2 Zn finger 448..468 CDD:275368 3/20 (15%)
zf-C2H2 475..496 CDD:278523 5/20 (25%)
C2H2 Zn finger 476..496 CDD:275368 5/19 (26%)
zf-H2C2_2 488..512 CDD:290200 6/29 (21%)
C2H2 Zn finger 504..524 CDD:275368 7/19 (37%)
zf-H2C2_2 516..541 CDD:290200 7/25 (28%)
C2H2 Zn finger 532..552 CDD:275368 6/19 (32%)
zf-H2C2_2 544..569 CDD:290200 9/26 (35%)
C2H2 Zn finger 560..580 CDD:275368 7/22 (32%)
zf-H2C2_2 573..597 CDD:290200 4/24 (17%)
C2H2 Zn finger 588..608 CDD:275368 3/19 (16%)
zf-H2C2_2 600..625 CDD:290200 5/24 (21%)
C2H2 Zn finger 616..635 CDD:275370 8/19 (42%)
C2H2 Zn finger 726..746 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 786..810
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24399
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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