DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10321 and ZNF134

DIOPT Version :9

Sequence 1:	NP_001261124.1	Gene:	CG10321 / 37464	FlyBaseID:	FBgn0034643	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_003426.3	Gene:	ZNF134 / 7693	HGNCID:	12918	Length:	427	Species:	Homo sapiens

Alignment Length:	289	Identity:	72/289 - (24%)
Similarity:	107/289 - (37%)	Gaps:	71/289 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   527 TEALVGPTMTVS-----SASPTPKRAKRSNHQIPAGVTLEPCD----------HQPPAAGST--- 573
            :||.:....|||     |..|...:.::.|.|    .||..|.          |:...:|..
Human   111 SEASIVKNCTVSKEPHPSEKPFTCKEEQKNFQ----ATLGGCQQKAIHSKRKTHRSTESGDAFHG 171

  Fly   574 -----TSSKLAAANSRQ--LVQTASVIAAAGADDNYEID---------ANLVTEFIRQHTSPLGS 622
                 ..|:...|.||:  |||...:   ...:..||..         |.|| :..|.||   |.
Human   172 EQMHYKCSECGKAFSRKDTLVQHQRI---HSGEKPYECSECGKAFSRKATLV-QHQRIHT---GE 229

  Fly   623 GRYICHLCSTEFRQFKGLQNHMHSHTNWIRANCKKQP-QCQICLKSFKGPGMLRMHMKTHDAESS 686
            ..|.|..|...|.:...|..|...||.       :.| :|..|.|.|.....|.:|.:.|:  .:
Human   230 RPYECSECGKTFSRKDNLTQHKRIHTG-------EMPYKCNECGKYFSHHSNLIVHQRVHN--GA 285

  Fly   687 TP-MCTICNRTFKSKAILYRHRQTHQ-QRAYCCGVANCRKNFSSAVNLKWHVERKHPEVVDPLFK 749
            .| .|:.|.:.|:.|:.|.:|...|. :..|.|  ::|.|:|.....|..| :|.|.|  ...|:
Human   286 RPYKCSDCGKVFRHKSTLVQHESIHTGENPYDC--SDCGKSFGHKYTLIKH-QRIHTE--SKPFE 345

  Fly   750 CGECGSLYDNVDSLQLHVESTDHSAEVQI 778
            |.|||..:.         .|:|:.|..::
Human   346 CIECGKFFS---------RSSDYIAHQRV 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10321	NP_001261124.1	zf-AD	12..80	CDD:214871
		ASF1_hist_chap	<405..516	CDD:304562
		C2H2 Zn finger	627..647	CDD:275368	5/19 (26%)
		C2H2 Zn finger	661..681	CDD:275368	6/19 (32%)
		C2H2 Zn finger	690..710	CDD:275368	6/19 (32%)
		C2H2 Zn finger	717..740	CDD:275368	7/22 (32%)
		C2H2 Zn finger	750..767	CDD:275368	4/16 (25%)
ZNF134	NP_003426.3	C2H2 Zn finger	178..198	CDD:275368	7/22 (32%)
		COG5048	<202..358	CDD:227381	49/182 (27%)
		C2H2 Zn finger	206..226	CDD:275368	4/20 (20%)
		C2H2 Zn finger	234..254	CDD:275368	5/19 (26%)
		C2H2 Zn finger	262..282	CDD:275368	6/19 (32%)
		C2H2 Zn finger	290..310	CDD:275368	6/19 (32%)
		C2H2 Zn finger	318..338	CDD:275368	7/22 (32%)
		C2H2 Zn finger	346..366	CDD:275368	7/29 (24%)
		C2H2 Zn finger	374..394	CDD:275368
		C2H2 Zn finger	402..422	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24399
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100