DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10321 and ZBTB25

DIOPT Version :9

Sequence 1:	NP_001261124.1	Gene:	CG10321 / 37464	FlyBaseID:	FBgn0034643	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_016877119.1	Gene:	ZBTB25 / 7597	HGNCID:	13112	Length:	560	Species:	Homo sapiens

Alignment Length:	626	Identity:	115/626 - (18%)
Similarity:	196/626 - (31%)	Gaps:	225/626 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 LITTAQIVAPQLAQIISTAPQSTTNGQATAAQSQFLPQLLQTPNGQTLQIVQQPNGTQTLQLVQL 296
            :|:..|:...::||      :||.|..|.:...|..|   .:|.|....|:...  ||.|..:.:
Human    63 VISCYQLRRQRIAQ------RSTWNLTAPSMFQQLAP---ASPQGIKFGILSLE--TQVLAELLI 116

  Fly   297 VPQRSLAPTGVTTVTTTTNATDMGQHVGASLGDADVQLLEDGCEVEDEELEDVYEQLDSKADHSF 361
            :.|.|:    :||:.|.:::               :.||               :||:.:.:..|
Human   117 LSQDSV----ITTMDTASHS---------------LVLL---------------QQLNMQREFGF 147

  Fly   362 E---TIVLDDDQQQDFLKDHHEHHQVMINEDLTQSESQDHEYFDDLDQQQAMDEIEDEEEQMKPE 423
            .   |:.:.|    .:.|.|........|            ||..:...|..:.|:.:...::|
Human   148 LCDCTVAIGD----VYFKAHRAVLAAFSN------------YFKMIFIHQTSECIKIQPTDIQP- 195

  Fly   424 EDQDTF---------------IIEEIQLEDDEMLDDPD-------------GEEIDQDCEYIGEE 460
               |.|               |::..:||:.......|             ..|..|.....|.:
Human   196 ---DIFSYLLHIMYTGKGPKQIVDHSRLEEGIRFLHADYLSHIATEMNQVFSPETVQSSNLYGIQ 257

  Fly   461 QDPHLSGDVDDDLEYSIMEPPDGETSVDIDQAFMDSEQSHHQQHQEEMQSISLENAVVEFSQATT 525
            ........|...||  :.|.|...:.   ::|   :.|..|.|.|..: :|.|::...:..:|..
Human   258 ISTTQKTVVKQGLE--VKEAPSSNSG---NRA---AVQGDHPQLQLSL-AIGLDDGTADQQRACP 313

  Fly   526 TTEALVGPTMTVSSASPTPKRAKRSNHQ-IPAGVTLEPCDHQPPAAGSTTSSKLAAANSRQLVQT 589
            .|:||                   ..|| .|..:..|.||.:
Human   314 ATQAL-------------------EEHQKPPVSIKQERCDPE----------------------- 336

  Fly   590 ASVIAAAGADDNYEIDANLVTE-FIRQHTSPLGSGRYICHLCSTEFRQFKGLQNHMHSH------ 647
             |||:.:....:.|:.....|| .::.|         :||.|...|.....|:.|:|:|
Human   337 -SVISQSHPSPSSEVTGPTFTENSVKIH---------LCHYCGERFDSRSNLRQHLHTHVSGSLP 391

  Fly   648 -------------------------------TNWIRANCKKQPQ------------CQICLKSFK 669
                                           :::|....::||.            .|:.|.| |
Human   392 FGVPASILESNDLGEVHPLNENSEALECRRLSSFIVKENEQQPDHTNRGTTEPLQISQVSLIS-K 455

  Fly   670 GPGMLRMHMKTHDAESSTPMCTICNRTFKSKAILYRHRQTHQQRAY----CCGVANC-RKNFS-- 727
            ....:.::.....:......||||...|..|:.|..|..||:.::|    |....|. .:.|.
Human   456 DTEPVELNCNFSFSRKRKMSCTICGHKFPRKSQLLEHMYTHKGKSYRYNRCQRFGNALAQRFQPY 520

  Fly   728 ----SAVNLKWHVERKHPEVVDPLFKCG-ECGSLYDNVDSL 763
                |.|:||  ..|...|.:|  ..|. |.....:|||::
Human   521 CDSWSDVSLK--SSRLSQEHLD--LPCALESELTQENVDTI 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10321	NP_001261124.1	zf-AD	12..80	CDD:214871
		ASF1_hist_chap	<405..516	CDD:304562	24/138 (17%)
		C2H2 Zn finger	627..647	CDD:275368	7/19 (37%)
		C2H2 Zn finger	661..681	CDD:275368	4/19 (21%)
		C2H2 Zn finger	690..710	CDD:275368	8/19 (42%)
		C2H2 Zn finger	717..740	CDD:275368	7/29 (24%)
		C2H2 Zn finger	750..767	CDD:275368	5/15 (33%)
ZBTB25	XP_016877119.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24399
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100