DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG10321 and BCL6

DIOPT Version :9

Sequence 1:NP_001261124.1 Gene:CG10321 / 37464 FlyBaseID:FBgn0034643 Length:855 Species:Drosophila melanogaster
Sequence 2:NP_001124317.1 Gene:BCL6 / 604 HGNCID:1001 Length:706 Species:Homo sapiens


Alignment Length:289 Identity:68/289 - (23%)
Similarity:102/289 - (35%) Gaps:52/289 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   530 LVGPT-MTVSSASPTPKRAKRSNHQIPAGVTLEP-------------------CDHQPP------ 568
            |..|| ::.|....|..:|.|.|:.:...:|..|                   |..|.|      
Human   425 LQSPTKLSASGEDSTIPQASRLNNIVNRSMTGSPRSSSESHSPLYMHPPKCTSCGSQSPQHAEMC 489

  Fly   569 --AAGSTTSSKLAAANSRQLVQTASVIAAAGADDNYEIDANLVTE-FIRQHTSPLGSGR-YICHL 629
              .||.|...::....|    :.:......||....|.|.....| .:::||....|.: |.|..
Human   490 LHTAGPTFPEEMGETQS----EYSDSSCENGAFFCNECDCRFSEEASLKRHTLQTHSDKPYKCDR 550

  Fly   630 CSTEFRQFKGLQNHMHSHTNWIRANCKKQPQCQICLKSFKGPGMLRMHMKTHDAESSTPMCTICN 694
            |...||....|.:|...||.      :|..:|.||...|..|..|:.|.:.|..|... .|..|.
Human   551 CQASFRYKGNLASHKTVHTG------EKPYRCNICGAQFNRPANLKTHTRIHSGEKPY-KCETCG 608

  Fly   695 RTFKSKAILYRHRQTHQ-QRAYCCGVANCRKNFSSAVNLKWHVERKHPEVVDPLFKCGECGSLYD 758
            ..|...|.|..|...|. ::.|.|.:  |...|.....||.|: |.|  ..:..:.|.:|...:.
Human   609 ARFVQVAHLRAHVLIHTGEKPYPCEI--CGTRFRHLQTLKSHL-RIH--TGEKPYHCEKCNLHFR 668

  Fly   759 NVDSLQLHVES-----TDHSAEVQISGQD 782
            :...|:||:..     |:...:.::|..|
Human   669 HKSQLRLHLRQKHGAITNTKVQYRVSATD 697

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10321NP_001261124.1 zf-AD 12..80 CDD:214871
ASF1_hist_chap <405..516 CDD:304562
C2H2 Zn finger 627..647 CDD:275368 6/19 (32%)
C2H2 Zn finger 661..681 CDD:275368 7/19 (37%)
C2H2 Zn finger 690..710 CDD:275368 6/19 (32%)
C2H2 Zn finger 717..740 CDD:275368 7/22 (32%)
C2H2 Zn finger 750..767 CDD:275368 4/16 (25%)
BCL6NP_001124317.1 BTB 22..126 CDD:279045
BTB 33..126 CDD:197585
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 317..349
Required for interaction with NuRD complex and for transcriptional repressor activity 376..379
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 407..467 10/41 (24%)
C2H2 Zn finger 520..541 CDD:275368 5/20 (25%)
C2H2 Zn finger 548..568 CDD:275368 6/19 (32%)
zf-H2C2_2 560..585 CDD:290200 9/30 (30%)
C2H2 Zn finger 576..596 CDD:275368 7/19 (37%)
zf-H2C2_2 588..613 CDD:290200 7/25 (28%)
C2H2 Zn finger 604..624 CDD:275368 6/19 (32%)
zf-H2C2_2 616..641 CDD:290200 7/26 (27%)
C2H2 Zn finger 632..652 CDD:275368 7/22 (32%)
zf-H2C2_2 645..669 CDD:290200 7/26 (27%)
C2H2 Zn finger 660..678 CDD:275368 5/17 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24399
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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